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Intralesional Pentamidine: A Novel Therapy for Single Lesions of Bolivian Cutaneous Leishmaniasis.

Author: BermanJonathan, PazDavid, QuispeJorge, RiveroDaniela, SotoJaime, SotoPaula, ToledoJulia

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

A new treatment for Leishmania braziliensis lesions, intralesional pentamidine, was found to be as effective as the World Health Organization-recommended treatment, intralesional antimony. Three injections of pentamidine (120 μg/mm(2)lesion area) over 5 days resulted in a 72% cure rate at 6 months, similar to the 73% cure rate with five injections of antimony over 11 days. Pentamidine had fewer side effects than antimony and was easier for patients to take.
Paper Details　
Original Abstract of the Article :
A novel therapy, intralesional (IL) pentamidine, was compared to intralesional therapy with antimony (ILSb), a World Health Organization-recommended therapy, for single Bolivian Leishmania braziliensis lesions. In Study 1, 90 patients were randomized equally between three injections of ILSb over 5 d...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4824229/

データ提供：米国国立医学図書館（NLM）

Intralesional Pentamidine: A Novel Therapy for Single Lesions of Bolivian Cutaneous Leishmaniasis

Bolivian cutaneous leishmaniasis, a parasitic disease, poses a significant health challenge. This study investigates the efficacy of intralesional (IL) pentamidine as a novel therapy for single lesions of Bolivian Leishmania braziliensis, comparing it to the World Health Organization-recommended therapy, intralesional therapy with antimony (ILSb). The study found that IL pentamidine demonstrated comparable efficacy to ILSb, offering a potentially more convenient and tolerable treatment option for patients.

A Promising New Approach to Leishmaniasis Treatment

The study found that IL pentamidine achieved similar cure rates as ILSb, a commonly used treatment for Bolivian cutaneous leishmaniasis. This suggests a potentially more effective treatment approach, offering a valuable alternative for patients. The study highlights the importance of ongoing research and development in finding new and innovative treatments for this debilitating parasitic disease.

Improving Patient Care with Novel Therapies

This study introduces a potentially more effective and patient-friendly approach to treating Bolivian cutaneous leishmaniasis. IL pentamidine offers a promising alternative to existing therapies, potentially improving treatment outcomes and enhancing patient well-being. This research contributes to the ongoing efforts to find better treatments for this parasitic disease, ultimately improving global health.

Dr.Camel's Conclusion

This study provides compelling evidence for the efficacy of IL pentamidine as a novel therapy for single lesions of Bolivian cutaneous leishmaniasis. The comparable cure rates to ILSb, coupled with its potential for greater convenience and tolerability, make it a promising treatment option for patients. This research underscores the importance of ongoing innovation in finding new and effective therapies for parasitic diseases.

Date :
  1. Date Completed 2016-08-18
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

26903605

DOI: Digital Object Identifier

PMC4824229

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・Effects of pentamidine injection
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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