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HLA-C and KIR combined genotype as new response marker for HBeAg-positive chronic hepatitis B patients treated with interferon-based combination therapy.

Author: JansenL, JanssenH L A, KootstraN A, ReesinkH W, SinnigeM J, StelmaF, TakkenbergR B, van DortK A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigated the association between HLA-C and KIR genotypes and the response to interferon-based therapy for chronic hepatitis B infection. The study found that specific combinations of HLA-C and KIR genotypes were associated with a better response to treatment in patients with chronic hepatitis B infection.
Paper Details　
Original Abstract of the Article :
Current treatment for chronic hepatitis B infection (CHB) consists of interferon-based therapy. However, for unknown reasons, a large proportion of patients with CHB do not respond to this treatment. Hence, there is a pressing need to establish response markers to select patients who will benefit fr...See full text at original site
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引用元：
https://doi.org/10.1111/jvh.12525

データ提供：米国国立医学図書館（NLM）

HLA-C and KIR Genotypes: A New Compass for Hepatitis B Treatment

This study delves into the role of specific genetic markers, HLA-C and KIR, in predicting treatment response in patients with chronic hepatitis B (CHB) infection. Treatment for CHB typically involves interferon-based therapy, but not all patients respond to it. The researchers investigated whether HLA-C and KIR genotypes could identify patients who are more likely to benefit from treatment. Their findings suggest that these genetic markers may indeed be useful in predicting treatment response, allowing for more personalized and effective treatment strategies.

Predicting Hepatitis B Treatment Response: A Genetic Oasis

The study's findings suggest that the combination of HLA-C and KIR genotypes can be a valuable predictor of treatment response in patients with CHB. This information could be used to identify patients who are more likely to benefit from interferon-based therapy, allowing for tailored treatment strategies and potentially avoiding unnecessary side effects. The study offers a promising tool for navigating the complexities of CHB treatment.

Understanding Hepatitis B Treatment: A Desert of Possibilities

This research highlights the importance of personalized medicine in treating CHB. The study's focus on identifying genetic markers that predict treatment response opens doors for more targeted and effective therapeutic strategies. The findings underscore the need for ongoing research to understand the complexities of viral infections and develop personalized treatments to address them.

Dr.Camel's Conclusion

This study investigates the role of HLA-C and KIR genotypes in predicting treatment response in patients with chronic hepatitis B. The findings suggest that these genetic markers could be used to personalize treatment strategies and optimize patient outcomes. The study underscores the importance of understanding the genetic factors that influence disease progression and treatment response.
Date :
  1. Date Completed 2017-10-30
  2. Date Revised 2017-11-24
Further Info :

Pubmed ID

26945896

DOI: Digital Object Identifier

10.1111/jvh.12525

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English

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