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The role of tenofovir alafenamide in future HIV management.

Author: AguiarC, AntelaA, BoffitoM, CompstonJ, Di PerriG, HendryB M, MallonP, Pourcher-MartinezV

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir with high antiviral efficacy and improved renal and bone safety compared to tenofovir disoproxil fumarate (TDF). Clinical data suggest that elvitegravir, cobicistat, emtricitabine, and TAF (E/C/F/TAF) as a single-tablet regimen offers highly effective viral suppression and a favorable safety profile for managing HIV infection, especially in patients with existing renal impairment and adolescents.
Paper Details　
Original Abstract of the Article :
HIV infection has become a chronic condition rather than an acute life-threatening disease in developed countries, thanks to consistent innovation and evolution of effective interventions. This has altered HIV management and created new challenges. People living with HIV (PLWHIV) are living longer a...See full text at original site
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引用元：
https://doi.org/10.1111/hiv.12401

データ提供：米国国立医学図書館（NLM）

The Role of Tenofovir Alafenamide in HIV Management

This review discusses the evolution of HIV treatment and the emergence of tenofovir alafenamide (TAF), a novel prodrug of tenofovir. The authors examine the clinical data supporting TAF's effectiveness and safety profile compared to tenofovir disoproxil fumarate (TDF).

TAF's Promise for HIV Management

The study found that TAF offers high antiviral efficacy at lower doses than TDF, with an improved renal and bone safety profile. The authors suggest that TAF has the potential to be a key component of future HIV treatment regimens, contributing to long-term viral suppression and minimizing the risk of comorbidities.

Improving HIV Treatment and Management

This research highlights the advancements in HIV treatment and the development of new agents like TAF. The improved safety profile and effectiveness of TAF could revolutionize HIV management, allowing patients to live longer, healthier lives with minimal side effects.

Dr. Camel's Conclusion

The quest to conquer HIV is like a long, arduous journey across the desert. TAF, like a refreshing spring oasis, offers a new, safer, and more effective approach to treatment. This research represents a significant step forward in the fight against HIV, bringing hope to those living with this challenging condition.

Date :
  1. Date Completed 2016-12-13
  2. Date Revised 2021-12-03
Further Info :

Pubmed ID

26952360

DOI: Digital Object Identifier

10.1111/hiv.12401

SNS
PICO Info
in preparation
Languages

English

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