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TarO-specific inhibitors of wall teichoic acid biosynthesis restore β-lactam efficacy against methicillin-resistant staphylococci.
Author: BalibarCarl J, BatchlettMichelle, DeVitoKristine, FlatteryAmy, GarlisiCharles G, GillCharles, HaSookhee, HouYan, KoseogluSandra, KuvelkarReshma, LabroliMarc, LeeSang Ho, LiangLianzhu, LiuJenny, MandalMihir, MannPaul, MayhoodTodd, MurgoloNicholas, RoemerTerry, SherXinwei, ShethPayal R, SuJing, TanChristopher, TanZheng, TawaPaul, WangHao, WenXiujuan, XiaoJianying, XiaoJing, YangChristine, YangShu-Wei, ZuckPaul
Original Abstract of the Article :
The widespread emergence of methicillin-resistant Staphylococcus aureus (MRSA) has dramatically eroded the efficacy of current β-lactam antibiotics and created an urgent need for new treatment options. We report an S. aureus phenotypic screening strategy involving chemical suppression of the growth ...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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引用元：
https://doi.org/10.1126/scitranslmed.aad7364
データ提供：米国国立医学図書館（NLM）
Targeting Wall Teichoic Acid Biosynthesis: A New Strategy to Combat Methicillin-Resistant Staphylococci
The battle against antibiotic resistance is a constant struggle, with bacteria like methicillin-resistant Staphylococcus aureus (MRSA) posing a significant threat to global health. This research explores a novel approach to tackling MRSA, focusing on the inhibition of wall teichoic acid biosynthesis. The study describes a screening strategy that led to the identification of two new chemical series, tarocin A and tarocin B, which specifically inhibit the first step in wall teichoic acid biosynthesis. The researchers demonstrate that these inhibitors, in combination with β-lactam antibiotics, exhibit potent bactericidal synergy against diverse clinical isolates of MRSA.
A New Weapon in the Fight Against Antibiotic Resistance
The study's findings offer a promising new strategy for combatting antibiotic resistance. The identification of tarocin A and tarocin B, specific inhibitors of wall teichoic acid biosynthesis, demonstrates the potential of targeting this pathway to overcome MRSA resistance. The observed synergy with β-lactams further enhances the potential of this approach.
Navigating the Shifting Sands of Antibiotic Resistance
As Dr. Camel, I'm hopeful that this research will contribute to a better understanding of antibiotic resistance and lead to the development of new and effective treatments. This study reminds us that the desert of antibiotic resistance is vast and complex, but with continued research and innovation, we can find new ways to combat this growing threat.
Dr. Camel's Conclusion
This study presents a novel strategy for combating methicillin-resistant Staphylococcus aureus (MRSA) by targeting wall teichoic acid biosynthesis. The identification of tarocin A and tarocin B, specific inhibitors of this pathway, demonstrates the potential for developing new combination therapies that effectively combat antibiotic resistance.
Date :
- Date Completed 2016-12-13
- Date Revised 2016-12-30
Further Info :
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