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Nutrient imbalances in depressive disorders. Possible brain mechanisms.

Author: O'RourkeD, WurtmanJ J, WurtmanR J

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Overview

This study examined the effectiveness of d-fenfluramine, a serotonin-releasing drug, in treating seasonal affective disorder (SAD) in 18 patients. Patients received either d-fenfluramine or a placebo for four weeks. D-fenfluramine significantly reduced depression scores compared to placebo, with a 71% decrease in overall depression scores and a 73% decrease in SAD-specific scores. Thirteen patients (72%) experienced a complete reversal of their symptoms while taking d-fenfluramine. The group also lost weight while taking d-fenfluramine. A follow-up study confirmed that d-fenfluramine remained effective for the full three-month duration of SAD symptoms. These findings suggest that d-fenfluramine may be a useful treatment for SAD and that serotonin plays a role in both the mood and appetite changes associated with the condition.
Paper Details　
Original Abstract of the Article :
We examined the utility of d-fenfluramine, a serotonin-releasing drug previously shown to diminish carbohydrate craving and weight gain in obese people, in treating patients with seasonal affective disorder (SAD), a variant of depression that occurs each fall and winter and is usually associated wit...See full text at original site
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引用元：
https://doi.org/10.1111/j.1749-6632.1989.tb53234.x

データ提供：米国国立医学図書館（NLM）

Nutrient Imbalances in Depressive Disorders

This study explores the fascinating connection between nutrient imbalances and depressive disorders, a topic that has intrigued researchers for years. Imagine a desert landscape where the lack of essential resources can hinder the growth of plants and animals. This study delves into the potential role of nutrient deficiencies in impacting mental health, specifically exploring their connection to depressive disorders.

Nutrient Imbalances and Depressive Symptoms

The study investigates the efficacy of d-fenfluramine, a serotonin-releasing drug, in treating seasonal affective disorder (SAD), a type of depression associated with hyperphagia and carbohydrate craving. This is like providing a specific type of fertilizer to a depleted desert soil, aiming to restore its vitality and promote healthy growth. The results showed that d-fenfluramine was significantly more effective than placebo in reducing depressive symptoms, suggesting a link between serotonin levels and SAD. This is like discovering a hidden source of water that revitalizes the desert ecosystem, bringing new life and balance to the environment.

Potential Role of Nutrient Imbalances in Mental Health

This research provides compelling evidence for the potential role of nutrient imbalances in contributing to depressive disorders, particularly SAD. It's a reminder that just as a desert ecosystem requires a balance of resources to thrive, our mental health depends on a balanced intake of essential nutrients.

Dr.Camel's Conclusion

This study offers a fascinating glimpse into the intricate relationship between our bodies and minds, highlighting the potential role of nutrient imbalances in impacting mental health. Just as a desert ecosystem requires a delicate balance of resources to flourish, our mental well-being can be affected by nutritional deficiencies. This research underscores the importance of a balanced diet and the potential for nutritional interventions to address mental health challenges. It's a reminder that nourishing our bodies can also nourish our minds, promoting overall well-being and resilience.
Date :
  1. Date Completed 1990-05-18
  2. Date Revised 2019-06-16
Further Info :

Pubmed ID

2699207

DOI: Digital Object Identifier

10.1111/j.1749-6632.1989.tb53234.x

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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