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Comparison of the effects of levocetirizine and losartan on diabetic nephropathy and vascular dysfunction in streptozotocin-induced diabetic rats.
Author: AnbarHanan S, GameilNariman M, ShehatouGeorge S G, SuddekGhada M
Original Abstract of the Article :
This work was designed to investigate the effects of levocetirizine, a histamine H1 receptor antagonist, on diabetes-induced nephropathy and vascular disorder, in comparison to an angiotensin II receptor antagonist, losartan. Diabetes was induced in male Sprague Dawley rats by a single intraperitone...See full text at original site
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引用元：
https://doi.org/10.1016/j.ejphar.2016.03.035
データ提供：米国国立医学図書館（NLM）
Levocetirizine: A Promising Oasis for Diabetic Nephropathy
This study compares the effects of levocetirizine, a histamine H1 receptor antagonist, and losartan, an angiotensin II receptor antagonist, on diabetic nephropathy and vascular dysfunction in streptozotocin-induced diabetic rats. The researchers evaluate the renoprotective and vasculoprotective effects of levocetirizine and losartan, exploring the potential of levocetirizine as a novel therapeutic agent for diabetic complications.
A Desert of Complications: Exploring Renoprotective and Vasculoprotective Therapies
The study suggests that levocetirizine may offer comparable renoprotective effects to losartan and potentially superior vasculoprotective effects in diabetic rats. The researchers found that levocetirizine improved renal function, attenuated oxidative stress, and restored nitric oxide bioavailability in diabetic kidney. The study’s findings indicate that levocetirizine holds promise as a potential therapeutic agent for managing diabetic nephropathy and vascular dysfunction.
A Journey Through the Desert of Diabetes: Seeking Effective Treatment Options
This research highlights the importance of exploring alternative therapeutic approaches for managing diabetic complications. The study’s findings suggest that levocetirizine may offer a valuable addition to the treatment arsenal for diabetic nephropathy and vascular dysfunction, potentially providing an alternative or complementary therapy to traditional approaches.
Dr. Camel's Conclusion
This research provides a refreshing oasis of hope in the desert of diabetic complications. It suggests that levocetirizine may offer a new and potentially effective treatment option for managing diabetic nephropathy and vascular dysfunction. This study encourages further investigation into the clinical applications of levocetirizine, particularly in the context of managing diabetic complications and improving patient outcomes.
Date :
- Date Completed 2017-03-06
- Date Revised 2017-03-06
Further Info :
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