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Current Threat of Triclabendazole Resistance in Fasciola hepatica.

Author: AndersonGlenn, BeddoeTravis, ElliottTimothy P, KelleyJane M, SkucePhilip, SpithillTerry W

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Triclabendazole (TCBZ) is the only known drug effective against liver fluke infections, but widespread resistance is a major problem. This review discusses the current status of TCBZ resistance, the global distribution, possible mechanisms of drug action, and potential solutions for sustainable livestock production.
Paper Details　
Original Abstract of the Article :
Triclabendazole (TCBZ) is the only chemical that kills early immature and adult Fasciola hepatica (liver fluke) but widespread resistance to the drug greatly compromises fluke control in livestock and humans. The mode of action of TCBZ and mechanism(s) underlying parasite resistance to the drug are ...See full text at original site
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引用元：
https://doi.org/10.1016/j.pt.2016.03.002

データ提供：米国国立医学図書館（NLM）

The Growing Threat of Triclabendazole Resistance in Fasciola hepatica

Parasitic infections, like a tenacious desert weed, can be challenging to control. This research delves into the alarming issue of triclabendazole resistance in Fasciola hepatica, a liver fluke that poses a significant threat to livestock and human health. The study examines the current status of triclabendazole resistance, its global distribution, and the potential mechanisms underlying drug resistance.

Addressing Drug Resistance in Liver Fluke Infections

The study highlights the urgent need for effective management of triclabendazole resistance, emphasizing the critical role of integrated parasite management (IPM) in controlling liver fluke infections. The researchers discuss the importance of strategic approaches, including drug rotation, alternative treatment options, and environmental control measures, to minimize the development and spread of drug resistance.

A Call for Integrated Strategies

This research underscores the importance of a multi-pronged approach to combating parasitic infections. The emergence of drug resistance in Fasciola hepatica emphasizes the need for integrated parasite management strategies that go beyond relying solely on chemical treatments.

Dr.Camel's Conclusion

This research is a stark reminder of the ever-evolving nature of parasitic infections. The emergence of triclabendazole resistance in Fasciola hepatica, like a desert sandstorm, poses a significant threat to livestock and human health. The researchers call for a comprehensive approach, including integrated parasite management strategies, to combat this formidable challenge.

Date :
  1. Date Completed 2017-06-20
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27049013

DOI: Digital Object Identifier

10.1016/j.pt.2016.03.002

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Languages

English

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