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Different effects of the nonsteroidal anti-inflammatory drugs meclofenamate sodium and naproxen sodium on proteasome activity in cardiac cells.

Author: CuiZiyou, GhoshRajeshwary, GildaJennifer E, GomesAldrin V, HwangSoyun M

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study investigates the cardiotoxicity of meclofenamate sodium (MS) and naproxen (NAP), nonsteroidal anti-inflammatory drugs (NSAIDs), on rat cardiac H9c2 cells and murine neonatal cardiomyocytes. MS, but not NAP, significantly inhibited proteasome activity and reduced cell viability by impairing mitochondrial function and increasing ROS production.
Paper Details　
Original Abstract of the Article :
The use of nonsteroidal anti-inflammatory drugs (NSAIDs) like meclofenamate sodium (MS), used to reduce pain, has been associated with an increased risk of cardiovascular disease (CVD). Naproxen (NAP), another NSAID, is not associated with increased risk of CVD. The molecular mechanism(s) by which N...See full text at original site
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引用元：
https://doi.org/10.1016/j.yjmcc.2016.03.016

データ提供：米国国立医学図書館（NLM）

Navigating NSAID Side Effects: Mclofenamate Sodium and Cardiovascular Risks

The field of [cardiology] is constantly seeking to understand the potential cardiovascular risks associated with [nonsteroidal anti-inflammatory drugs (NSAIDs)]. This study investigated the effects of [meclofenamate sodium (MS)] and [naproxen sodium (NAP)], two commonly used NSAIDs, on [proteasome activity] and [cardiotoxicity] in cardiac cells. The researchers found that MS, but not NAP, significantly inhibited proteasome activity and reduced cell viability at pharmacological levels. These findings provide valuable insights into the potential mechanisms underlying the cardiovascular risks associated with certain NSAIDs.

NSAIDs: A Complex Relationship with Heart Health

The study suggests that MS may pose a greater cardiovascular risk compared to NAP. The findings highlight the importance of considering individual patient factors and potential drug interactions when prescribing NSAIDs. Healthcare professionals should carefully weigh the benefits and risks of different NSAIDs, particularly in individuals with existing cardiovascular conditions.

Making Informed Choices About NSAID Use

For individuals taking NSAIDs, it’s crucial to be aware of the potential cardiovascular risks associated with these medications. While NSAIDs can provide effective pain relief, it’s essential to discuss potential risks with healthcare professionals. Choosing the appropriate NSAID and monitoring for any adverse effects is crucial to ensure safe and effective treatment.

Dr. Camel's Conclusion

This study reminds us that even in the seemingly straightforward realm of pain relief, there are hidden currents that can impact our cardiovascular health. NSAIDs, while valuable tools for managing pain, can also have complex effects on the heart. The research underscores the importance of careful consideration and personalized treatment plans, ensuring that we navigate the landscape of NSAID use with caution and awareness.

Date :
  1. Date Completed 2017-05-31
  2. Date Revised 2018-03-08
Further Info :

Pubmed ID

27049794

DOI: Digital Object Identifier

10.1016/j.yjmcc.2016.03.016

Related Literature

Article Analysis
・Effects of meclofenamate
SNS
PICO Info
in preparation
Languages

English

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