Effects of meclofenamate: A Synthesis of Findings from 26 Studies

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Original Abstract of the Article

Major Research Findings

Meclofenamate is a non-steroidal anti-inflammatory drug (NSAID) that has been studied for its effects on various physiological processes. 22 demonstrated that meclofenamate selectively inhibits thromboxane A2 synthase activity at specific concentrations, while having no effect on other prostaglandin-related enzymes. This suggests a potential benefit in preventing blood clots. However, 2 revealed that meclofenamate can worsen reduced blood flow to the kidneys in rabbits experiencing mild bleeding. Moreover, 6 showed that meclofenamate can exacerbate renal function decline in sodium-depleted dogs. These studies indicate that meclofenamate may be beneficial in preventing blood clots, but it could also strain the kidneys.

25 suggests that meclofenamate could potentially worsen hypertension caused by kidney disease in rats. This research emphasizes the need for caution when using meclofenamate in patients with kidney issues. Conversely, 8 showed that meclofenamate, along with ibuprofen, can prevent the worsening of heart strain caused by pulmonary microembolism in rabbits. This suggests a potential role for meclofenamate in treating pulmonary microembolism. Additionally, 18 showed that meclofenamate can suppress the production of progesterone, a female hormone, in monkeys. This finding hints at a potential for meclofenamate in managing hormone-related conditions.

Research in 13 indicates that meclofenamate is effective in alleviating post-surgical abdominal pain. Furthermore, 14 shows that meclofenamate can dilate blood vessels in the brain. This suggests a potential benefit in preventing strokes. Additionally, 12 indicates that meclofenamate can promote water excretion from the kidneys. This finding suggests a potential role for meclofenamate in treating edema.

3 suggests that meclofenamate could potentially worsen hypertension. Furthermore, 10 shows that meclofenamate reduces blood flow to the kidneys in rabbits. Moreover, suggests that meclofenamate might strain the kidneys. These studies indicate that meclofenamate could contribute to worsening hypertension and strain the kidneys.

11 shows that meclofenamate increases blood flow to the brain, liver, and bronchi in rabbits. 17 shows that meclofenamate inhibits vasoconstriction in the pulmonary arteries of sheep. 9 further shows that meclofenamate inhibits vasoconstriction in the pulmonary arteries of piglets. These findings demonstrate meclofenamate's potential to increase blood flow to certain organs and inhibit vasoconstriction in the pulmonary arteries.

19 reveals that meclofenamate can enhance fetal breathing movements in sheep. Additionally, 26 shows that meclofenamate can strengthen immune cell function, suggesting its potential role in preventing infections. However, 1 shows that meclofenamate can reduce blood flow to the kidneys in rabbits, emphasizing the need for caution in patients with kidney disease.

24 indicates that meclofenamate can promote the activity of GABA, a neurotransmitter in the brain, suggesting a potential benefit in treating anxiety and insomnia. However, 16 suggests that meclofenamate could potentially weaken the protective effects of the heart, highlighting the need for caution in patients with heart conditions. Moreover, 23 reveals that meclofenamate could potentially inhibit heart cell function, suggesting a potential role in exacerbating heart disease.

15 shows that meclofenamate can suppress the production of renin, a hormone released by the kidneys, suggesting a potential benefit in treating hypertension. However, 20 suggests that meclofenamate could worsen hypertension, highlighting the need for caution in patients with hypertension.

Benefits and Risks

Benefits Summary

Meclofenamate has shown various potential benefits, including:

  • Potential to prevent blood clots. 22
  • Potential to treat pulmonary microembolism. 8
  • Effective in alleviating post-surgical abdominal pain. 13
  • Potential to prevent strokes. 14
  • Potential to treat edema. 12
  • Potential to manage hormone-related conditions. 18
  • Potential to prevent infections. 26
  • Potential to treat anxiety and insomnia. 24
  • Potential to treat hypertension. 15

Risks Summary

Meclofenamate carries potential risks, including:

Research Comparisons

Research Similarities

Many studies agree that meclofenamate inhibits prostaglandin synthesis. Prostaglandins are substances that play various roles in the body, and meclofenamate's effects can be attributed, in part, to its interaction with prostaglandins.

Research Differences

Meclofenamate's effects have been shown to differ depending on the specific disease, tissue, and dosage. For example, meclofenamate may be beneficial in preventing blood clots but could also strain the kidneys. It's crucial to follow a doctor's instructions carefully and be aware of potential side effects when taking meclofenamate.

Consistency and Contradictions in Results

Meclofenamate research has yielded consistent results in some areas, while producing contradictory findings in others. This variation could be attributed to the fact that meclofenamate's effects can differ depending on the specific disease, tissue, and dosage.

Real-World Application Considerations

While meclofenamate offers potential benefits, it's essential to be aware of its potential side effects. Always adhere to a doctor's instructions and be vigilant about any adverse reactions. Additionally, meclofenamate could potentially strain the kidneys and heart; therefore, patients with these conditions should exercise extra caution.

Current Research Limitations

Many meclofenamate studies have been conducted on animals, requiring further research to understand its effects on humans. Additionally, the long-term impact of meclofenamate remains unclear, necessitating more research to ascertain its long-term safety.

Future Research Directions

Future meclofenamate research should prioritize clinical trials to examine its effects on humans. It's also crucial to conduct research into its long-term impact and safety. By delving deeper into meclofenamate's mechanisms of action, researchers can potentially reduce side effects and enhance its effectiveness.

Conclusion

Meclofenamate is a drug with various potential benefits and risks. It's essential to follow a doctor's instructions and be aware of potential side effects. Due to many unanswered questions about meclofenamate, further research is needed to clarify its effects and safety.

Literature analysis of 26 papers
Positive Content
15
Neutral Content
2
Negative Content
9
Article Type
1
0
0
0
26
2.

Effects of meclofenamate and captopril on blood flow to the kidney and spleen in conscious rabbits subjected to mild haemorrhage.

Author: BanksR A, BeilinL J, SoltysJ, DavidsonL

Renal vasoconstriction
Splenic vasoconstriction

The dependence on vasodilator prostaglandins increased in the renal and splenic vascular beds of conscious rabbits subjected to mild haemorrhage.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Effects of phenoxybenzamine, metoprolol, captopril, and meclofenamate on cardiovascular function in deoxycorticosterone acetate hypertensive Yucatan miniature swine.

Author: CicconeC D, ZambraskiE J

Increased blood pressure
Increased pressor sensitivity

DOCA-induced hypertension in Yucatan miniature swine was associated with increased alpha-adrenergic activity and/or increased smooth muscle responsiveness to circulating catecholamines, leading to elevated total peripheral resistance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

4.

Effects of sodium meclofenamate on postoperative pain following periodontal surgery.

Author: GallardoF, RossiE

Analgesic
Postoperative pain

Meclofenamate, a nonsteroidal anti-inflammatory drug, is effective in relieving pain following periodontal surgery. In a double-blind study, meclofenamate was superior to placebo and aspirin in reducing pain intensity during the second hour after administration.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

5.

Effects of high salt intake and meclofenamate on arterial pressure and renal function in the spontaneously hypertensive rat.

Author: ChrysantS G

Increased arterial pressure
Renal damage

High sodium intake combined with meclofenamate had a greater damaging effect on arterial pressure and renal function in spontaneously hypertensive rats than salt alone.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, Non-P.H.S.Research funding provided by US government agencies other than the Public Health Service.

Language : English

6.

Effects of indomethacin and meclofenamate on renin release and renal hemodynamic function during chronic sodium depletion in conscious dogs.

Author: De ForrestJ M, DavisJ O, FreemanR H, SeymourA A, RoweB P, WilliamsG M, DavisT P

High renin activity
Reduced renal function

Indomethacin is effective in reducing plasma renin activity. It also causes a decrease in renal hemodynamic function.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Effects of meclofenamate and captopril on adrenal blood flow: contrasts in conscious rabbits at rest and after hemorrhage.

Author: BanksR A, BeilinL J, SoltysJ, DavidsonL

Maintained adrenal blood flow during hemorrhage
Decreased plasma catecholamines
Reduced adrenal blood flow at rest

Adrenal blood flow is modulated by vasodilator prostaglandins and to a lesser extent angiotensin II. Hemorrhage overrode the effects of meclofenamate and captopril.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

9.

Effects of meclofenamate on pulmonary vascular resistance correlate with postnatal age in young piglets.

Author: ReddingG J, McMurtryI, ReevesJ T

Increased pulmonary resistance

Sodium meclofenamate, a prostaglandin synthetase inhibitor, was found to increase pulmonary artery pressure and total pulmonary resistance in piglets less than 12 days old. This effect was not seen in older piglets. The magnitude of the change in total pulmonary resistance correlated inversely with postnatal age.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

11.

Dose-dependent effects of meclofenamate on peripheral vasculature of conscious rabbits.

Author: BanksR A, BeilinL J, SoltysJ

Increased brain blood flow
Reduced renal blood flow

Meclofenamate reduced renal blood flow but increased blood flow to the brain, bronchial, hepatic, and testicular circulation in conscious rabbits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Effects of meclofenamate on the renal actions of mannitol infusion in conscious rabbits. Evidence for osmotic control of renal prostaglandin synthesis?

Author: BhattacharyaJ, BeilinL J

Diuretic effect
Blood flow changes

Mannitol's diuretic effect occurred independently of increases in renal blood flow or prostaglandin synthesis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Effects of meclofenamate and acetaminophen on abdominal pain following tubal occlusion.

Author: HuangK C, WolfeW M, TsuedaK, SimpsonP M, CaissieK F

Postoperative pain relief
None reported

Meclofenamate was more effective than acetaminophen in reducing postoperative abdominal pain after tubal occlusion. It also provided substantial analgesia for 4 hours.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Cerebral vasodilation and prostacyclin. The effects of aspirin and meclofenamate in vitro.

Author: ChapleauC E, WhiteR P, RobertsonJ T

Enhanced prostacyclin action

Meclofenamic acid, a prostaglandin synthetase inhibitor, enhanced the vasodilator action of prostacyclin on cerebral arteries, unlike aspirin.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

17.

Meclofenamate blocks the pulmonary arterial vasopressor effects of leukotriene B4 in awake sheep.

Author: MillerR F, PurvisA W, LeffertsP L, SnapperJ R

Reduced pulmonary arterial pressure
Cyclooxygenase product mediation

LTB4 induced a significant rise in pulmonary arterial pressure in sheep, suggesting a vasoactive effect. This effect was mediated indirectly through cyclooxygenase metabolites of arachidonic acid, as pretreatment with meclofenamate blocked the rise in pulmonary arterial pressure.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

18.

Disparate effects of the prostaglandin synthesis inhibitors, meclofenamate, and flurbiprofen on monkey luteal tissue in vitro.

Author: Zelinski-WootenM B, SargentE L, MolsknessT A, StoufferR L

Luteolysis

Sodium meclofenamate (Mec) inhibits prostaglandin (PG) synthesis and adenylate cyclase activity in primate luteal cells, leading to reduced progesterone production.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

19.

Effects of meclofenamate on breathing movements in fetal sheep before delivery.

Author: WallenL D, MuraiD T, ClymanR I, LeeC H, MaurayF E, KittermanJ A

Meclofenamate, a prostaglandin synthase inhibitor, caused a significant decrease in [PGE2] and a significant increase in FBM in eight fetal sheep, suggesting that the decrease in FBM before delivery is not dependent on the concurrent increase in [PGE2].

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

21.

Effects of meclofenamate and captopril on renal and other regional vascular beds after mild haemorrhage in conscious rabbits.

Author: BanksR A, BeilinL J, SoltysJ, DavidsonL

Maintained renal blood flow during hemorrhage
Renal vasoconstriction
Splenic vasoconstriction

Prostaglandins were found to modulate regional blood flow in conscious rabbits subjected to mild haemorrhage. The dependence on vasodilator prostaglandins increased in the renal and splenic vascular beds.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

22.

Differential effects of ibuprofen, indomethacin, and meclofenamate on prostaglandin endoperoxide H2 metabolism.

Author: MayeuxP R, KadowitzP J, McNamaraD B

PGH2 inhibition

Ibuprofen, indomethacin, and meclofenamate exhibited different effects on terminal enzyme activities involved in prostaglandin metabolism. Ibuprofen did not affect PGI2 synthase, TXA2 synthase, or PGE2 isomerase, while indomethacin selectively inhibited PGI2 synthase and meclofenamate selectively inhibited TXA2 synthase. These findings highlight the importance of NSAID choice and concentration in influencing prostaglandin metabolism.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

24.

Modifications of diflunisal and meclofenamate carboxyl groups affect their allosteric effects on GABAA receptor ligand binding.

Author: Uusi-OukariMikko, VähätaloLaura, LiljebladArto

GABAAR modulation

Modifying the carboxyl group of diflunisal and meclofenamate can affect their ability to modulate GABAARs.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

26.

Effects of meclofenamate on natural killer cell activity.

Author: StadlerI, HammadA, AmbrusJ, ChadhaK C

Increased NK cell activity

Meclofenamate significantly increased natural killer cell activity when target cells were pretreated for 12-24 hours.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

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