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In Vitro Effects of Pantoprazole on Platelet Aggregation in Blood Samples From Clopidogrel and Aspirin-treated Patients.

Author: HolmManne, KarlssonElias, van der LindenJan A

Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

In vitro addition of pantoprazole significantly decreased platelet aggregation in blood samples from clopidogrel and aspirin-treated patients, suggesting a potential drug-drug interaction. Further studies are needed to explore clinical relevance.
Paper Details　
Original Abstract of the Article :
Platelet inhibition during treatment with the antiplatelet drug clopidogrel is prone to great interindividual variability and is believed to be affected by several factors such as genetics and drug-drug interactions. Proton pump inhibitors have been shown to interfere with the liver metabolism of cl...See full text at original site
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引用元：
https://doi.org/10.1097/FJC.0000000000000401

データ提供：米国国立医学図書館（NLM）

Pantoprazole's Potential Impact on Platelet Aggregation: A Cautionary Tale

The field of [pharmacology] is constantly seeking to understand the interactions between different medications. This research investigates the potential [in vitro] effects of [pantoprazole] on [platelet aggregation] in blood samples from patients taking [clopidogrel and aspirin]. The study seeks to clarify the potential for [drug-drug interactions] between pantoprazole and clopidogrel, which is a crucial consideration in [cardiovascular medicine].

A Potential for Drug Interactions

The study found that [pantoprazole] significantly [reduced platelet aggregation] in blood samples from patients taking clopidogrel and aspirin. This finding raises concerns about the potential for [clinical interactions] between these medications. The study suggests that [further research] is needed to fully understand the implications of this in vitro finding and determine whether it translates to clinically significant effects. It also highlights the need for [careful monitoring] of patients taking both pantoprazole and clopidogrel to assess for any potential adverse effects on platelet function.

Navigating the Complexities of Drug Interactions

This research underscores the complexities of [drug-drug interactions] and the importance of [pharmacokinetic considerations] when prescribing medications. It reminds us that the effects of medications can be influenced by a variety of factors, including [genetic variability and co-medication]. The study emphasizes the importance of [patient-centered care] and [individualized treatment] to ensure optimal outcomes and minimize the risk of adverse effects.

Dr. Camel's Conclusion

Just as a camel can navigate a vast desert landscape, we must carefully consider the potential interactions between different medications. This research reminds us that navigating the complex world of pharmaceuticals requires caution, knowledge, and a keen eye for detail.
Date :
  1. Date Completed 2017-11-27
  2. Date Revised 2018-12-03
Further Info :

Pubmed ID

27110745

DOI: Digital Object Identifier

10.1097/FJC.0000000000000401

Related Literature

Article Analysis
・Effects of pantoprazole
SNS
PICO Info
in preparation
Languages

English

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