Effects of pantoprazole: A Synthesis of Findings from 22 Studies

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Original Abstract of the Article

Major Research Findings

Pantoprazole is a proton pump inhibitor (PPI) that is commonly used to treat gastrointestinal disorders. Several studies have investigated the effects of pantoprazole on the metabolism of other drugs. For example, a study found that pantoprazole may affect the clearance of the active metabolite of clopidogrel, an antiplatelet drug, in patients with coronary artery disease. 22 However, another study indicated that pantoprazole does not significantly alter the metabolism of clozapine, an antipsychotic medication. 12 Additionally, a study revealed that pantoprazole does not affect the pharmacokinetics of rosuvastatin, a cholesterol-lowering drug, in healthy volunteers. 20 Furthermore, research has suggested that pantoprazole may have positive effects on the nervous system, potentially protecting against epileptic seizures and neuronal damage in rats. 6

Benefits and Risks

Benefit Summary

Pantoprazole effectively reduces stomach acid production, aiding in the treatment of gastrointestinal disorders like peptic ulcers and gastroesophageal reflux disease (GERD). Some studies suggest that pantoprazole may also have neuroprotective effects, but this remains to be conclusively proven.

Risk Summary

Pantoprazole can potentially interfere with the metabolism of other drugs, so it is crucial to discuss any other medications you are taking with your doctor if you are prescribed pantoprazole. Long-term use of pantoprazole has been associated with side effects like osteoporosis, highlighting the importance of consulting your doctor regarding the duration of treatment.

Comparison Across Studies

Similarities

Multiple studies indicate that pantoprazole may affect the metabolism of other drugs. However, the extent and specific mechanisms of these effects vary across studies. Most of the research focuses on the pharmacokinetic aspects of pantoprazole's influence, while further investigation is needed to determine the clinical implications.

Differences

The specific drugs affected by pantoprazole vary between studies. For instance, one study suggests that pantoprazole may affect clopidogrel's active metabolite clearance, while another study demonstrates no impact on clozapine metabolism. 22 12 These findings highlight the potential for pantoprazole's effects to be drug-specific.

Consistency and Contradictions in Findings

While numerous studies suggest pantoprazole's potential to interact with other drugs, directly comparing results is challenging due to variations in the drugs studied and research methodologies. Therefore, further research is necessary to fully understand how pantoprazole impacts the metabolism of different medications.

Real-World Application Notes

If you are taking pantoprazole, it is essential to discuss any other medications you are using with your doctor. Furthermore, consult with your doctor regarding the duration of pantoprazole treatment, especially for long-term use.

Current Limitations in Research

Research on pantoprazole's effects remains insufficient, highlighting the need for further investigations, particularly regarding long-term impact and safety. Additionally, pantoprazole's effects may vary between individuals, emphasizing the need for more data to encompass individual variability.

Future Directions for Research

Future research should focus on understanding the long-term effects and safety of pantoprazole. Further investigation is needed to determine how pantoprazole interacts with the metabolism of various drugs. Additionally, studies evaluating the clinical implications of pantoprazole's effects are crucial.

Conclusion

Several studies suggest that pantoprazole may affect the metabolism of other drugs, highlighting the importance of discussing all medications with your doctor if you are taking pantoprazole. While our understanding of pantoprazole's effects is still evolving, further research is vital to ensure its safe and effective use. By deepening our knowledge of pantoprazole's interactions, we can promote safer and more effective medication practices.

Literature analysis of 22 papers
Positive Content
14
Neutral Content
4
Negative Content
4
Article Type
10
0
0
0
22
1.

Effects of oral pantoprazole on 24-hour intragastric acidity and plasma gastrin profiles.

Author: HannanA, WeilJ, BroomC, WaltR P

Gastric acidity reduction
Gastrin elevation

Pantoprazole, a proton pump inhibitor, effectively reduces intragastric acidity in a dose-dependent manner. In a study involving 11 men, pantoprazole doses of 40 and 60 mg daily significantly increased median 24-hour gastric pH compared to placebo, with a higher effect observed with the higher dose.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Pharmacodynamic effects of single doses of rabeprazole 20 mg and pantoprazole 40 mg in patients with GERD and nocturnal heartburn.

Author: WarringtonS, BaisleyK, LeeD, LomaxK, DelemosB, BoyceM, MorocuttiA

Increased pH

This open-label, randomized, two-way crossover, clinical pharmacology study compared the antisecretory effects of single doses of rabeprazole and pantoprazole in patients with GERD and a history of nocturnal heartburn. The study found that a single oral dose of rabeprazole 20 mg increased intragastric pH more than pantoprazole 40 mg did throughout the 24 h after dosing.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

3.

Pharmacodynamic evaluation of pantoprazole therapy on clopidogrel effects: results of a prospective, randomized, crossover study.

Author: FerreiroJosé Luis, UenoMasafumi, TomaselloSalvatore D, CapodannoDavide, DesaiBhaloo, DharmashankarKodlipet, SeecheranNaveen, KodaliMurali K, DarlingtonAndrew, PhamJohn-Paul, Tello-MontoliuAntonio, CharltonRonald K, BassTheodore A, AngiolilloDominick J

Assess impact of pantoprazole therapy

This study assessed the impact of high-dose pantoprazole therapy, a proton pump inhibitor, on clopidogrel-mediated pharmacodynamic effects. The study aimed to determine whether the drug interaction between clopidogrel and proton pump inhibitors is a class effect or a drug effect and if timing of drug administration affects the interaction.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

Intragastric pH effect of 20mg of levo-pantoprazole versus 40mg of racemic pantoprazole the first seven days of treatment in patients with gastroesophageal reflux disease.

Author: Remes-TrocheJ M, García GarcíaF D, Rojas-LoureiroG, Rivera-GutiérrezX, Reyes-HuertaJ, Amieva-BalmoriM

Gastric pH reduction

Levo-pantoprazole, the S-enantiomer of pantoprazole, is a proton pump inhibitor that has shown to be faster and stronger in animal studies than its racemic formulation. This study aims to evaluate the effects of levo-pantoprazole versus racemic pantoprazole on intragastric pH in humans.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

The effects of pantoprazole vs. placebo on 1-year outcomes, resource use and employment status in ICU patients at risk for gastrointestinal bleeding: a secondary analysis of the SUP-ICU trial.

Author: HallingChristine Marie Bækø, MøllerMorten Hylander, MarkerSøren, KragMette, KjellbergJakob, PernerAnders, Gyrd-HansenDorte

Stress ulcer prevention

Stress ulcer prophylaxis (SUP) with proton pump inhibitors (PPIs) is widely used to prevent stress-related gastrointestinal (GI) bleeding in intensive care unit (ICU) patients. This secondary analysis of the SUP-ICU trial assessed 1-year outcomes in the pantoprazole vs. placebo groups.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

7.

Effects of Calcium and Annatto Tocotrienol Supplementation on Bone Loss Induced by Pantoprazole in Male Rats.

Author: ChinKok-Yong, ThongBenjamin Ka Seng, KamalullohRhivaldy Faahim, MohamadNur Vaizura, WongSok Kuan, Mohd ArlamsyahAzlan, TrilianaRahma, SoelaimanIma Nirwana

Bone loss prevention

Prolonged use of proton pump inhibitors can lead to bone loss. This study investigates the effects of calcium alone and in combination with annatto tocotrienol or vitamin D3 on preventing bone loss caused by pantoprazole, a proton pump inhibitor.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Comparison of Antioxidant Effects of the Proton Pump-Inhibiting Drugs Omeprazole, Esomeprazole, Lansoprazole, Pantoprazole, and Rabeprazole.

Author: AbedMohammed N, AlassafFawaz A, JasimMahmood H M, AlfahadMohanad, QazzazMohannad E

PPI efficacy
Oxidative damage
Peptic lesions

Peptic lesions result from an imbalance between aggressive factors and gastro-protective mediators. Antioxidants are crucial for protecting the gastrointestinal lining, and their loss can lead to oxidative stress, a major factor in peptic ulcer development. While proton pump inhibitors effectively reduce acid production, they do not address oxidative damage, which may contribute to future lesions.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

10.

Effects of oral/enteral nutrition alone versus plus pantoprazole on gastrointestinal bleeding in critically ill patients with low risk factor: a multicenter, randomized controlled trial

Author: GündoğanKürşat, KarakocEmre, TekeTurgut, ZermanAvşar, EsmaogluAliye, TemelŞahin, GüvenMuhammet, SungurMurat

Increased ICU stay

In patients at low risk for GI bleeding and under oral/enteral nutritional support, the use of PPIs may not reduce the risk of bleeding.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

11.

Esomeprazole vs pantoprazole effects on cyclosporine levels in kidney transplantation: A randomized clinical trial.

Author: El-BohyDoaa, El SharkawyMagdy, Abo-ElazmSoheir, ShahinSara, BchariWaleed, MancyAzza, El HamamsyManal

Cyclosporine level variations

This prospective, parallel, open-label trial compared the influence of pantoprazole and esomeprazole on serum cyclosporine trough levels in renal transplant recipients. Pantoprazole had a greater impact on cyclosporine levels compared to esomeprazole.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

The Effects of Co-prescription of Pantoprazole on the Clozapine Metabolism.

Author: KuzinMaxim, SchoretsanitisGeorgios, HaenEkkehard, DammannGerhard, HiemkeChristoph, GründerGerhard, PaulzenMichael

Adding pantoprazole to an ongoing treatment with clozapine did not alter the metabolism of clozapine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

13.

Effects of Somatostatin Combined with Pantoprazole on Serum C-Reactive Protein and Intercellular Adhesion Molecule-1 in Severe Acute Pancreatitis.

Author: LiuJun, WangGuoliang, LiuYan, HuangLei, XuXiangang, WangJun

SAP treatment

Somatostatin combined with pantoprazole was more effective than pantoprazole alone in treating severe acute pancreatitis (SAP), as demonstrated by shorter abdominal pain relief, intestinal function recovery, and ventilator weaning times in the somatostatin group. The somatostatin group also had lower serum C-reactive protein (CRP) and intercellular adhesion molecule-1 (ICAM-1) levels after treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

14.

Effects of the Proton Pump Inhibitors Omeprazole and Pantoprazole on the Cytochrome P450-Mediated Metabolism of Venlafaxine.

Author: KuzinMaxim, SchoretsanitisGeorgios, HaenEkkehard, StegmannBenedikt, HiemkeChristoph, GründerGerhard, PaulzenMichael

Increased venlafaxine levels

Omeprazole and pantoprazole, both proton pump inhibitors (PPIs), significantly increased plasma concentrations of venlafaxine and its active metabolite, suggesting clinically relevant inhibitory effects on the metabolism of venlafaxine.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

20.

No effects of pantoprazole on the pharmacokinetics of rosuvastatin in healthy subjects.

Author: HuguetJ, LuJ, GaudetteF, ChiassonJ-L, HametP, MichaudV, TurgeonJ

This study investigated the effects of pantoprazole, a proposed BCRP inhibitor, on rosuvastatin disposition. Concomitant administration of pantoprazole with rosuvastatin did not affect rosuvastatin plasma concentrations.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

21.

In Vitro Effects of Pantoprazole on Platelet Aggregation in Blood Samples From Clopidogrel and Aspirin-treated Patients.

Author: KarlssonElias, HolmManne, van der LindenJan A

Reduced platelet aggregation

In vitro addition of pantoprazole significantly decreased platelet aggregation in blood samples from clopidogrel and aspirin-treated patients, suggesting a potential drug-drug interaction. Further studies are needed to explore clinical relevance.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Observational StudyResearch that observes and collects data on participants' behavior and outcomes in their natural state, without intervention.

Language : English

22.

Omeprazole, pantoprazole, and CYP2C19 effects on clopidogrel pharmacokinetic-pharmacodynamic relationships in stable coronary artery disease patients.

Author: SimonNicolas, FinziJonathan, CaylaGuillaume, MontalescotGilles, ColletJean-Philippe, HulotJean-Sébastien

Reduced clopidogrel response

CYP2C19*2 allele carriage and the use of omeprazole/esomeprazole were associated with inter-individual variability in the active metabolite clearance of clopidogrel. This highlights the importance of considering genetic factors and drug interactions when prescribing clopidogrel.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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