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Evaluation of potential for pharmacokinetic interaction between mometasone furoate and formoterol fumarate after oral inhalation from a fixed-dose combination metered-dose inhaler device.

Author: CutlerDavid L, HubbellJames, Johnson-LevonasAmy O, KantesariaBhavna S, KosoglouTeddy, YunanMona

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study compared the pharmacokinetics of a fixed-dose combination (FDC) containing mometasone furoate (MF) and formoterol fumarate (F) in a pressurized metered dose inhaler (MDI) with the individual administration of MF and F. Systemic exposures to MF and formoterol were similar following treatment with the FDC MDI device versus individual or concomitant use of single-ingredient MDI devices.
Paper Details　
Original Abstract of the Article :
A fixed-dose combination (FDC) containing mometasone furoate (MF) and formoterol fumarate (F) in a pressurized metered dose inhaler (MDI) is approved for asthma and is being developed for COPD. This randomized, open-label, 4-period crossover study compared single-dose pharmacokinetics of MF 800 µg; ...See full text at original site
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引用元：
https://doi.org/10.1002/cpdd.94

データ提供：米国国立医学図書館（NLM）

Exploring the Desert of Pharmacokinetic Interactions: A Study of Mometasone Furoate and Formoterol Fumarate

In the intricate world of [pharmacology], understanding the interactions between different medications is crucial for ensuring patient safety and efficacy. This study delves into the potential for pharmacokinetic interactions between mometasone furoate and formoterol fumarate, two medications commonly used in the treatment of respiratory conditions. It's like venturing into a vast and sometimes unpredictable desert, where the interplay of different elements can lead to unexpected outcomes. The study [research method] to evaluate the potential for pharmacokinetic interactions between mometasone furoate and formoterol fumarate when administered together in a fixed-dose combination metered-dose inhaler device.

A Collaborative Journey: Mometasone Furoate and Formoterol Fumarate

The study's findings suggest that there is no significant pharmacokinetic interaction between mometasone furoate and formoterol fumarate when administered together in a fixed-dose combination inhaler. This suggests that this combination therapy can be safely and effectively used for patients with respiratory conditions. It's like discovering that two camels, each with unique strengths, can work together harmoniously to navigate the desert.

Navigating the Desert of Drug Interactions: Ensuring Patient Safety

This research emphasizes the importance of understanding the potential for drug interactions. It provides valuable information for clinicians and pharmacists, allowing them to make informed decisions about medication combinations to ensure patient safety. It's a reminder that the desert of pharmacology is complex and ever-evolving, requiring continuous vigilance to ensure the best possible outcomes for our patients.

Dr.Camel's Conclusion

This study provides valuable insights into the potential for pharmacokinetic interactions between mometasone furoate and formoterol fumarate. It demonstrates that this combination can be safely and effectively administered, offering a valuable tool for managing respiratory conditions. It's a reminder that we must continuously explore the complex landscape of drug interactions, ensuring that our patients receive the best possible care.

Date :
  1. Date Completed 2018-01-22
  2. Date Revised 2018-06-08
Further Info :

Pubmed ID

27128612

DOI: Digital Object Identifier

10.1002/cpdd.94

Related Literature

Article Analysis
・Effects of mometasone oral inhalation
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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