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Antitumor Effects of Systemic DNAse I and Proteases in an In Vivo Model.

Author: ChanonaJosé, De La Cruz-SigüenzaDesiree, Dueñas-GonzálezAlfonso, García-LópezPatricia, González-BallesterosMauricio, Gutiérrez-DíazBlanca, Pérez-CardenasEnrique, Taja-ChayebLucía, Trejo-BecerrilCatalina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study explores the antitumor effects of DNAse I and a protease mix on circulating cell-free DNA (cfDNA) in cancer patients. The enzymes effectively degraded cfDNA in vitro and in vivo, showing potential for inhibiting tumor growth.
Paper Details　
Original Abstract of the Article :
Background Cell-free DNA circulates in cancer patients and induces in vivo cell transformation and cancer progression in susceptible cells. Based on this, we hypothesized that depletion of circulating DNA with DNAse I and a protease mix could have antitumor effects. Study design The study aimed to d...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5739158/

データ提供：米国国立医学図書館（NLM）

Fighting Cancer with Enzymes

This study proposes an intriguing approach to cancer treatment: using a combination of enzymes, DNAse I, and a protease mix, to degrade cell-free DNA in the bloodstream. The researchers conducted in vitro and in vivo experiments, akin to carefully observing sand dune formations, to evaluate the effectiveness of this enzymatic cocktail. They found that this approach could significantly reduce DNA levels in the blood and inhibit tumor growth in mice.

A Promising New Frontier

This study opens up a potentially exciting new frontier in cancer treatment. The researchers believe that their findings could lead to the development of new therapies that target cell-free DNA and potentially curb cancer progression.

A New Weapon in the Fight Against Cancer

This research offers a glimmer of hope in the ongoing fight against cancer. By exploring new and innovative approaches, we can create a future where cancer is no longer a life-threatening disease.

Dr.Camel's Conclusion

This study explores the potential of a novel enzymatic approach to combat cancer. It is a reminder that we must continue to explore new pathways and innovations in the pursuit of more effective cancer treatments.

Date :
  1. Date Completed 2017-10-06
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

27146129

DOI: Digital Object Identifier

PMC5739158

Related Literature

Article Analysis
・Effects of dnase
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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