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No effects of pantoprazole on the pharmacokinetics of rosuvastatin in healthy subjects.

Author: ChiassonJ-L, GaudetteF, HametP, HuguetJ, LuJ, MichaudV, TurgeonJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study investigated the effects of pantoprazole, a proposed BCRP inhibitor, on rosuvastatin disposition. Concomitant administration of pantoprazole with rosuvastatin did not affect rosuvastatin plasma concentrations.
Paper Details　
Original Abstract of the Article :
PURPOSE: Rosuvastatin disposition is modulated by the expression and activity of several membrane transporters including BCRP (ABCG2). The objective of our study was to investigate the effects of pantoprazole, a previously proposed BCRP inhibitor, on the disposition of rosuvastatin. METHODS: The im...See full text at original site
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引用元：
https://doi.org/10.1007/s00228-016-2065-6

データ提供：米国国立医学図書館（NLM）

Pantoprazole and Rosuvastatin: No Interaction Found

This study investigates the potential for drug interactions between pantoprazole, a proton pump inhibitor commonly used to treat heartburn, and rosuvastatin, a medication used to lower cholesterol. The researchers conducted a study to assess the effect of pantoprazole on the pharmacokinetics of rosuvastatin in healthy volunteers. The study found no significant interaction between the two drugs, suggesting that pantoprazole does not affect the absorption, distribution, metabolism, or elimination of rosuvastatin. This research offers reassurance to patients taking both medications, suggesting that they can be used safely together.

Pantoprazole and Rosuvastatin: A Safe Combination

This research provides valuable information for patients taking both pantoprazole and rosuvastatin, demonstrating that the two drugs can be safely used together without significant interactions. The study's findings offer reassurance to healthcare providers and patients, supporting the continued use of these medications in combination to manage both heartburn and high cholesterol.

Navigating the Desert of Drug Interactions: Finding Safe Pathways

The potential for drug interactions is a significant concern for healthcare providers and patients, as these interactions can lead to unexpected and potentially harmful effects. This research provides valuable insights into the relationship between pantoprazole and rosuvastatin, demonstrating that these two medications can be safely used together. It's like navigating a vast desert landscape, where careful planning and knowledge of potential obstacles are essential for a safe and successful journey.

Dr. Camel's Conclusion

This research sheds light on the intricate landscape of drug interactions, offering valuable information for safe and effective medication use. The study's findings suggest that pantoprazole and rosuvastatin can be used together without significant interactions, offering a reassuring discovery for patients taking both medications.

Date :
  1. Date Completed 2017-02-23
  2. Date Revised 2019-01-11
Further Info :

Pubmed ID

27146814

DOI: Digital Object Identifier

10.1007/s00228-016-2065-6

Related Literature

Article Analysis
・Effects of pantoprazole
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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