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Dual-pH responsive micelle platform for co-delivery of axitinib and doxorubicin.

Author: HuangYuan, LiLian, SunWei, XuXiuli, ZhouZhou

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study developed a micellar platform for the co-delivery of two cancer drugs, axitinib and doxorubicin. This approach showed improved tumor accumulation, cell internalization, and tumor growth inhibition (by 88%), suggesting promise for combinatory cancer therapy.
Paper Details　
Original Abstract of the Article :
While the complicated pathogenesis of cancer results in limited therapeutic efficacy of current mono-drug treatment, combination therapy by multiple drugs is becoming increasingly attractive due to the decreased side effects and synergistic anti-cancer activities. The recently emerging modality is t...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijpharm.2016.04.060

データ提供：米国国立医学図書館（NLM）

Dual-pH Responsive Micelles: A New Frontier in Cancer Treatment

The fight against cancer is a complex and challenging journey, requiring innovative approaches to target tumors effectively. This study, like a team of scientists venturing into the world of nanotechnology, explores the potential of a dual-pH responsive micellar platform for co-delivering axitinib and doxorubicin, two potent anticancer drugs. The authors, seeking to enhance the efficacy of cancer treatment, investigate the potential of this novel drug delivery system to target tumor cells more precisely and reduce side effects. Their findings offer valuable insights into the potential of nanotechnology to revolutionize cancer therapy.

A Targeted Approach: Dual-pH Responsive Micelles for Enhanced Cancer Treatment

The study reveals that the dual-pH responsive micellar platform effectively delivers axitinib and doxorubicin to their respective targets, demonstrating a significant advantage over traditional drug delivery systems. The researchers observed improved tumor accumulation, cell internalization, and tumor spheroids penetration, resulting in enhanced cytotoxicity and a reduction in tumor growth. This research, like a guided missile targeting a specific location, offers a promising approach to combatting cancer more effectively.

Dr. Camel's Conclusion

This study showcases the potential of dual-pH responsive micelles to revolutionize cancer therapy by enhancing drug delivery and reducing side effects. This novel technology, like a beacon of hope in the desert of cancer treatment, offers a promising avenue for developing more targeted and effective therapies.

Date :
  1. Date Completed 2017-07-18
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27154256

DOI: Digital Object Identifier

10.1016/j.ijpharm.2016.04.060

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・Side Effects of axitinib
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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