The UVB1 Vitamin D analogue inhibits colorectal carcinoma progression.

Author: AlonsoEliana Noelia, ArévaloJulián, CurinoAlejandro Carlos, FacchinettiMaría Marta, FallYagamare, FermentoMaría Eugenia, FerronatoMaría Julia, GandiniNorberto Ariel, GómezGenerosa, López RomeroAlejandro, QuevedoMario Alfredo, RivadullaMarcos Lois, VillegasMaría Emilia

Paper Details 
Original Abstract of the Article :
Vitamin D has been shown to display a wide variety of antitumour effects, but their therapeutic use is limited by its severe side effects. We have designed and synthesized a Gemini vitamin D analogue of calcitriol (UVB1) which has shown to display antineoplastic effects on different cancer cell line...See full text at original site
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引用元:
https://doi.org/10.1016/j.jsbmb.2016.05.019

データ提供:米国国立医学図書館(NLM)

UVB1: A New Hope in Colorectal Cancer Treatment

Colorectal cancer, a major public health concern, has spurred a relentless search for effective therapies. This study explores the potential of a novel vitamin D analogue, UVB1, in combating colorectal carcinoma progression. The researchers employed a multi-faceted approach, combining in silico modeling, in vitro cell culture, and in vivo animal studies to investigate UVB1's effects on human colorectal carcinoma cells.

UVB1: A Powerful Ally Against Colorectal Cancer

The study revealed that UVB1 effectively induced apoptosis, inhibited cell migration and invasion, and reduced tumor volume in animal models. Furthermore, UVB1 modulated the expression of key genes involved in cancer cell behavior. These findings suggest that UVB1 holds promise as a potential chemotherapeutic agent for colorectal cancer.

A Promising Future for Cancer Therapy

This research highlights the potential of UVB1 as a safe and effective alternative to conventional cancer treatments. Its ability to target specific cellular pathways involved in colorectal cancer progression without causing severe side effects, such as hypercalcemia, makes UVB1 an attractive candidate for further investigation and clinical development.

Dr. Camel's Conclusion

Imagine a thirsty traveler in the desert, desperately searching for an oasis. This study shows that UVB1, like a hidden oasis, provides a powerful antidote to the relentless march of colorectal cancer. Its ability to induce apoptosis, inhibit invasion, and modulate critical genes involved in cancer progression is a beacon of hope in the fight against this devastating disease. While more research is needed to fully understand its therapeutic potential, UVB1 holds immense promise as a novel weapon in our arsenal against colorectal cancer.

Date :
  1. Date Completed 2017-06-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27208626

DOI: Digital Object Identifier

10.1016/j.jsbmb.2016.05.019

Related Literature

SNS
PICO Info
in preparation
Languages

English

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