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Comparative efficacy of biological agents in methotrexate-refractory rheumatoid arthritis patients: a Bayesian mixed treatment comparison.

Author: ChoiMiyoung, ChoiSeongmi, HyunMin Kyung, JungYoung Ok, KimHyun Ah, KimMin-Jeong, LeeSung Yeon, SonKyeong Min, TchoeHa Jin

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

Biologic medications, which target inflammation, are effective treatments for rheumatoid arthritis (RA), but they are expensive and long-term safety concerns exist. This study compared the effectiveness of different biologic treatments to standard RA medications in patients who didn't respond to methotrexate (MTX).
Paper Details　
Original Abstract of the Article :
Biological agents (biologics) targeting proinflammatory signaling have emerged as an important treatment option in rheumatoid arthritis (RA). Despite the clinical effectiveness of biologics for patients with RA who do not respond to 'traditional' disease-modifying anti-rheumatic drugs (DMARDs), ther...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5432786/

データ提供：米国国立医学図書館（NLM）

Biological Agents: A New Era in Rheumatoid Arthritis Treatment

Rheumatoid arthritis (RA) is a chronic autoimmune disease that causes inflammation and pain in the joints. This study compares the efficacy of various biological agents, which target proinflammatory signaling, for patients with RA who have not responded to methotrexate (MTX). Biological agents have emerged as a significant treatment option for RA, offering new hope for patients who have not benefited from traditional therapies.

Comparing Biological Agents: A Bayesian Approach

The researchers used a Bayesian mixed treatment comparison approach to compare the efficacy of various biologics and traditional DMARDs. This approach allowed for a more comprehensive analysis of the available data, providing valuable insights into the relative effectiveness of different treatment options. The findings of this study could help clinicians make more informed decisions about the best treatment for individual patients with RA.

The Importance of Effective RA Treatment

RA can have a significant impact on quality of life, causing pain, stiffness, and disability. This study highlights the importance of finding effective treatment options for RA, especially for patients who have not responded to traditional therapies. Just as a camel uses its strength and adaptability to thrive in the desert, individuals with RA need to find ways to manage their condition and live fulfilling lives.

Dr. Camel's Conclusion

This research delves into the rapidly evolving landscape of RA treatment, exploring the effectiveness of biological agents. The study emphasizes the need for personalized treatment approaches and the importance of finding the most effective therapies for each patient. Just as a camel navigates the desert with a keen understanding of its environment, researchers are constantly seeking new solutions for RA, striving to improve the lives of those affected by this debilitating disease.

Date :
  1. Date Completed 2018-03-21
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

27253239

DOI: Digital Object Identifier

PMC5432786

Related Literature

Article Analysis
・Effective treatment of rheumatoid arthritis
SNS
PICO Info
in preparation
Languages

English

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