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Evaluation of Pancreatic Cancer Clinical Trials and Benchmarks for Clinically Meaningful Future Trials: A Systematic Review.
Author: BerlinJordan D, FleshmanJulie M, MatrisianLynn M, RahibLola
Original Abstract of the Article :
IMPORTANCE: Progress in the treatment of pancreatic adenocarcinoma has been minimal; it remains the only major cancer type with a 5-year survival rate of less than 10%. OBJECTIVE: To explore why a large proportion of advanced pancreatic cancer clinical trials executed over the past 25 years have ha...See full text at original site
Dr.Camel's Paper Summary Blogラクダ博士について
ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元:
https://doi.org/10.1001/jamaoncol.2016.0585
データ提供:米国国立医学図書館(NLM)
Navigating the Desert of Pancreatic Cancer Research
Pancreatic cancer is a formidable foe, a relentless sandstorm in the desert of human health. It's a disease that often progresses rapidly, with limited treatment options. This study examines the challenges of pancreatic cancer clinical trials and explores the need for more effective strategies to combat this disease.
Setting Benchmarks for Success
The researchers reviewed decades of clinical trials and found that a significant number of studies had negative results. It's like trying to find a hidden oasis in a vast and treacherous desert. However, the study identifies several benchmarks that could help to improve the success rate of future trials. The researchers propose that stricter criteria for phase 2 trials, such as requiring a 50% improvement in overall survival, could help to prioritize promising treatments and avoid unnecessary phase 3 trials.
Guiding the Caravan Towards a Cure
This study highlights the critical need for more effective strategies in the fight against pancreatic cancer. The researchers' recommendations could help to streamline clinical trials, prioritize promising treatments, and ultimately lead to a more successful journey through the desert of this disease.
Dr. Camel's Conclusion
Pancreatic cancer research is a challenging journey through a vast and unforgiving desert. This study provides a roadmap for navigating this landscape, offering valuable insights into the need for setting clear benchmarks and prioritizing promising treatment options. This research is a critical step towards finding a cure for pancreatic cancer, a beacon of hope in the darkness.
Date :
- Date Completed 2017-01-30
- Date Revised 2018-12-02
Further Info :
Related Literature
English
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