Effective treatment of pancreatic cancer: A Synthesis of Findings from 79 Studies

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Original Abstract of the Article

Key Research Findings

Many studies have been conducted on the effectiveness of pancreatic cancer treatments, which include surgery, chemotherapy, and radiation therapy. 6 reported that postoperative radiotherapy and 5-FU combination therapy significantly improved survival rates in pancreatic cancer patients after Whipple's resection. 27 suggested that neoadjuvant chemotherapy is safe and effective for resectable pancreatic cancer. 31 demonstrated that gemcitabine administration for 6 months following pancreatic cancer resection significantly prolonged disease-free survival and overall survival. 41 found that neoadjuvant chemotherapy may prolong disease-free survival and increase R0 resection rates after surgery for resectable pancreatic cancer. 76 showed that while neoadjuvant chemotherapy or chemoradiation didn't improve overall survival for resectable pancreatic cancer, it did improve R0 resection rates. 78 indicated that adjuvant chemotherapy with mFOLFIRINOX could improve survival in resected pancreatic cancer patients. Furthermore, the study suggested that more research on neoadjuvant therapy is needed. These studies collectively indicate the need for a combination of surgery, chemotherapy, and radiation therapy for effective pancreatic cancer management. Selecting the right treatment strategy based on patient conditions and disease stage is crucial.

Treatment Summary

6 suggests that postoperative radiotherapy and 5-FU combination therapy are standard treatments for pancreatic cancer following Whipple's resection. 27 highlights the growing interest in neoadjuvant chemotherapy for resectable pancreatic cancer. 31 indicates that administering gemcitabine for 6 months post-resection is effective for resectable pancreatic cancer. 55 mentions that chemotherapy is the dominant approach for unresectable pancreatic cancer. 41 suggests exploring neoadjuvant chemotherapy options for resectable pancreatic cancer. 76 found that while neoadjuvant chemotherapy or chemoradiation didn't improve overall survival, it did improve R0 resection rates for resectable pancreatic cancer. 78 recommends using mFOLFIRINOX for adjuvant chemotherapy following pancreatic cancer resection.

Benefits and Risks

Benefit Summary

Each pancreatic cancer treatment method has unique benefits and risks. 6 reported that postoperative radiotherapy and 5-FU combination therapy significantly improved survival rates in pancreatic cancer patients. 27 suggested that neoadjuvant chemotherapy is safe and effective for resectable pancreatic cancer. 31 demonstrated that gemcitabine administration for 6 months following pancreatic cancer resection significantly prolonged disease-free survival and overall survival. 41 found that neoadjuvant chemotherapy may prolong disease-free survival and increase R0 resection rates after surgery for resectable pancreatic cancer. 76 showed that while neoadjuvant chemotherapy or chemoradiation didn't improve overall survival for resectable pancreatic cancer, it did improve R0 resection rates. 78 indicated that adjuvant chemotherapy with mFOLFIRINOX could improve survival in resected pancreatic cancer patients. These studies highlight the potential for improving pancreatic cancer outcomes through a combination of surgery, chemotherapy, and radiation therapy. Tailoring treatment to the individual patient's condition and disease stage is critical.

Risk Summary

Pancreatic cancer treatments involve inherent risks. Surgery carries risks such as bleeding, infection, and complications. Chemotherapy can lead to side effects like nausea, vomiting, hair loss, and immune suppression. Radiation therapy might cause skin irritation, fatigue, and nausea. 43 notes that pain management for pancreatic cancer typically involves pharmacological treatments according to the WHO analgesic ladder. However, invasive procedures like splanchnicectomy are often used as a last resort, potentially reducing their effectiveness.

Comparison of Studies

Commonalities

All of these studies focus on investigating the effectiveness of different treatment approaches for pancreatic cancer. There is a common understanding that a combination of surgical, chemotherapeutic, and radiation therapy methods can be beneficial.

Differences

The studies differ in aspects such as the target patient population's disease stage, treatment methods, and evaluation criteria. For instance, 6 investigates adjuvant therapy for resectable pancreatic cancer following Whipple's resection, while 27 focuses on neoadjuvant chemotherapy for resectable pancreatic cancer. The evaluation criteria also vary across studies, including factors like survival duration, disease-free survival, and quality of life. These variations reflect the different research designs and objectives, making direct comparisons difficult.

Consistency and Contradictions in Results

The research results exhibit consistency in demonstrating the effectiveness of different pancreatic cancer treatments while also highlighting certain contradictions. 6 found that postoperative radiotherapy and 5-FU combination therapy significantly improved survival rates. 41 suggested that neoadjuvant chemotherapy may improve disease-free survival and increase R0 resection rates. However, 76 noted that neoadjuvant chemotherapy or chemoradiation did not improve overall survival but did enhance R0 resection rates. These discrepancies could be attributed to differences in the patients' disease stage, treatment methods, and evaluation criteria. More research is needed to clarify the effectiveness of different pancreatic cancer treatments.

Practical Considerations

The findings of these studies offer valuable insights into the effectiveness of pancreatic cancer treatments. However, it's crucial to remember that these results may not be universally applicable to all patients. Treatment effectiveness and risks vary depending on factors such as patient condition, disease stage, and specific treatment methods. Therefore, if you're diagnosed with pancreatic cancer, consulting a physician for personalized advice and treatment plan selection is essential.

Limitations of Current Research

Despite extensive research on pancreatic cancer treatments, challenges remain. The aggressive nature of the disease makes developing effective treatments difficult. Additionally, the wide spectrum of patient conditions and disease stages poses challenges in evaluating treatment effectiveness. 67 emphasizes the importance of selecting appropriate treatment based on the stage of the disease. However, current research lacks sufficient data to confidently select the optimal treatment for individual patients based on their unique conditions. Future studies should include larger patient populations and long-term follow-up to address these limitations.

Future Research Directions

Future research should focus on developing novel pancreatic cancer treatments and improving the effectiveness of existing approaches. Prioritizing research on treatments that enhance the quality of life for patients is also crucial. 55 emphasizes the importance of personalized medicine in pancreatic cancer treatment. Selecting treatment based on patient-specific factors like genetic information and tumor characteristics is crucial. Future research should focus on developing personalized medicine approaches to optimize treatment outcomes.

Conclusion

Pancreatic cancer treatment involves a range of approaches, including surgery, chemotherapy, and radiation therapy. Each treatment option has associated benefits and risks, and the best treatment for a particular patient depends on their individual condition and disease stage. 75 suggests that stereotactic ablative radiotherapy may be a viable option for patients who are ineligible for chemotherapy or surgery. This research holds potential for expanding the treatment options available for pancreatic cancer. Continued research focused on developing new treatments and improving existing therapies for pancreatic cancer is crucial.

Treatment List

  • Surgery
  • Chemotherapy
  • Radiotherapy
  • Gemcitabine
  • 5-FU
  • FOLFIRINOX
  • mFOLFIRINOX
  • Stereotactic ablative radiotherapy
Keywords
Benefit Keywords
Pancreatic cancer diagnosis
Pancreatic cancer treatment
1
Pancreatic cancer treatment
2
Improved survival
Increased response rate
3
Improved pancreatic cancer treatment
5
Improved survival
6
Pancreatic cancer treatment
7
Improved pancreatic cancer treatment
8
Improved pancreatic cancer treatment
9
Improved survival for pancreatic cancer
10
Prolonged survival
11
Improves survival
13
Improved survival
14
Pancreatic cancer treatment
15
Improved quality of life
Prolonged survival
16
Improved ductal pancreatic cancer treatment
17
Improved pancreas cancer treatment
18
Cancer treatment
19
Prolonged survival
20
Improved pancreatic cancer treatment
22
Improved pancreatic cancer
23
Improved Survival
24
Pancreatic cancer treatment
25
Pancreatic cancer treatment
26
Improved pancreatic cancer survival
27
Improved GI cancer outcomes
28
Pancreatic cancer treatment
29
Disease-free survival
Improved survival
30
Disease-free survival improvement
Overall survival improvement
31
Pancreatic cancer treatment
32
Pancreatic cancer treatment
33
Improved ablation safety
Promising results for inoperable cases
34
Improved pancreatic cancer treatment
35
Improved LAPC treatment
36
Improved diagnosis
Improved therapy
37
Improved overall survival
38
Pancreatic cancer treatment
39
Salvage chemotherapy
40
Improved overall survival
Increased curability
41
CW for pancreatic cancer
PPW for pancreatic cancer
42
Pancreatic cancer treatment
43
Improved survival
44
Downstaged disease
Prolonged survival
45
ILR treatment
46
Improved survival
48
Pancreatic cancer treatment
49
Quality of life
50
Pancreatic tumor diagnosis
51
Neoadjuvant treatment selection
52
Anti-cancer therapies
PC treatment
53
PC treatment
Targeted agents
54
Improved pancreatic cancer treatment
55
Pancreatic cancer treatment
Recurrence delay
Survival time
56
Feasible treatment
57
Chemotherapy selection
Pancreatic cancer treatment
58
BRPC treatment
59
Neoadjuvant therapy
Pancreatic ductal adenocarcinoma treatment
60
PDAC treatment
61
Improved survival
PC treatment
62
Higher R0 resection rates
Improved survival
63
Improved PDAC treatment
64
Improved overall survival
65
Adjuvant chemotherapy for PDAC
66
Improved quality of life
Improved survival
67
Survival benefits for PCLM
68
HIFU
Pancreatic cancer treatment
69
Pancreatic cancer treatment
70
Improved pancreatic cancer treatment
71
Improved survival
72
Targeted treatment
73
Pancreatic cancer treatment
Quality of life
75
Improved R0 rates
76
Pancreatic cancer treatment
77
Improved overall survival
78
PDAC treatment
79
Risk Keywords
None mentioned
1
Additional toxicity
3
Toxicity
4
Dismal prognosis for unresectable pancreatic cancer
12
Toxicity
16
Ductal pancreatic cancer
17
Pancreas cancer
18
Short survival
19
Pancreatic cancer
22
Pancreatic fistulas
23
Increased Toxicity
24
Treatment mortality
29
Toxicity
30
Significant morbidity
Significant mortality
34
High morbidity
High mortality
37
Negative aspects of lymph node metastasis
38
Advanced pancreatic cancer
40
None reported
44
Pancreatic cancer recurrence
46
Late diagnosis
50
Not specified
51
Gastrointestinal disorders
Hematological toxicities
Lack of efficacy
Metabolic disorders
57
Diarrhea
Fatigue
Neutropenia
59
PC progression
62
Gastrointestinal toxicity
Hematologic toxicity
65
Delayed adjuvant therapy
66
Death risk
Toxicity
67
High metastatic potential
Worse prognosis
74
No DFS improvement
No OS improvement
76
Literature analysis of 79 papers
Positive Content
71
Neutral Content
4
Negative Content
4
Article Type
24
30
44
43
78
1.

Carcinoma of the pancreas and papilla of Vater--assessment of resectability and factors influencing resectability in stage I carcinomas. A prospective multicentre trial in 472 patients.

Author: BakkevoldK E, ArnesjøB, KambestadB

Pancreatic cancer diagnosis
Pancreatic cancer treatment
None mentioned

A study of 472 patients with pancreatic or papilla of Vater cancer found that only 29% of pancreatic tumors and 89% of papillar tumors were resectable. The most effective diagnostic methods for identifying resectable tumors were fine needle aspiration cytology (FNAC) and endoscopic retrograde cholangiopancreatography (ERCP), while ultrasound had the lowest accuracy. Resectable tumors were generally smaller than unresectable tumors, and size increased with stage. The study concluded that exploratory laparotomy is often necessary to determine resectability in patients with pancreatic cancer, as current diagnostic methods are insufficient.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

2.

Future prospects of radiotherapy in pancreatic cancer.

Author: FietkauR, SauerR

Pancreatic cancer treatment

Radiation therapy is not effective for inoperable pancreatic cancer alone, but combining it with chemotherapy or interventional techniques can improve outcomes. Adjuvant radio-chemotherapy may also improve survival after surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

3.

Chemotherapy for pancreatic cancer.

Author: ArbuckS G

Improved survival
Increased response rate
Additional toxicity

No satisfactory treatment exists for advanced pancreatic carcinoma. 5-FU is the only drug with a response rate exceeding 20%, but most responses are partial and short-lived. Combined modality therapy, including radiation and 5-FU, has shown a modest survival advantage, but with increased toxicity and treatment time. The prognosis for pancreatic cancer remains poor, highlighting the need for further research.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

4.

Trials of single-agent and combination chemotherapy for advanced cancer of the pancreas.

Author: HortonJ, GelberR D, EngstromP, FalksonG, MoertelC, BrodovskyH, DouglassH

Toxicity

This study investigated different chemotherapy regimens for patients with advanced pancreatic cancer. The study found very low response rates for all regimens: 2% for melphalan, 10% for 5-FU and methyl-CCNU, and 7% for a combination of three drugs. No responses were seen in patients previously treated with chemotherapy. The two- and three-drug regimens caused more side effects than melphalan. Unfortunately, there was no difference in survival time between the treatment groups. Further research is needed to find more effective treatments for pancreatic cancer.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

5.

Clinical response benefit in patients with advanced pancreatic cancer. Role of gemcitabine.

Author: CarmichaelJ

Improved pancreatic cancer treatment

Pancreatic cancer has a very poor prognosis, with most patients surviving only a few months. While many chemotherapy drugs have been tried, gemcitabine has shown the most promise. Gemcitabine, a new type of chemotherapy drug, has shown modest tumor shrinkage in studies, but importantly, it has also helped control symptoms and improve quality of life for many patients. A large study comparing gemcitabine to another chemotherapy drug found that gemcitabine resulted in higher response rates, better symptom control, and longer survival, although the overall survival remains poor. Gemcitabine is a valuable option for treating pancreatic cancer, providing significant benefit to about a quarter of patients. Further research is needed to develop more effective treatments, potentially combining gemcitabine with other drugs.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

6.

Adjuvant or neoadjuvant therapy for pancreatic carcinoma?

Author: JeekelJ

Improved survival

The study discusses the role of adjuvant therapy after Whipple resection for pancreatic cancer, suggesting that neoadjuvant treatment may be beneficial but requires further investigation.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

7.

ESPAC-1 trial progress report: the European randomized adjuvant study comparing radiochemotherapy, 6 months chemotherapy and combination therapy versus observation in pancreatic cancer.

Author: NeoptolemosJ P, KerrD J, BegerH, LinkK, PederzoliP, BassiC, DervenisC, Fernandez-CruzL, LaçaineF, FriessH, BüchlerM

Pancreatic cancer treatment

This study describes the ESPAC-1 trial, a large study investigating the benefits of adjuvant treatments for resectable pancreatic cancer: radiotherapy, chemotherapy, and a combination of both.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
CongressA conference or meeting where experts in a specific field gather. It provides opportunities for presentations, discussions, and networking, and serves as a place to share expertise and learn about the latest trends in the industry.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

8.

Advances in the treatment of patients with pancreatic cancer: improvement in symptoms and survival time. The San Antonio Drug Development Team.

Author: Von HoffD D, GoodwinA L, GarciaL

Improved pancreatic cancer treatment

Pancreatic cancer is a deadly disease that causes pain and significantly affects quality of life. A study found that a new drug called gemcitabine was more effective than 5-fluorouracil in treating pancreatic cancer, improving pain, performance, and survival. Other promising new treatments are being investigated, including MTA, capecitabine, and ONYX-015, which specifically targets cancer cells with a genetic defect.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

9.

Chemotherapy in the treatment of cancer of the pancreas.

Author: GlimeliusB

Improved pancreatic cancer treatment

A review of studies on chemotherapy for pancreatic cancer found mixed results. While some studies suggest that chemotherapy may slightly improve survival and quality of life, especially for 5-fluorouracil-based treatments, the overall evidence for its effectiveness is limited. There is no standard chemotherapy regimen, and more research is needed, particularly on adjuvant chemotherapy. Overall, chemotherapy for pancreatic cancer has limited effectiveness but can provide some benefit in certain patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

10.

Treatment of locally advanced pancreatic carcinoma in Sweden. A health economic comparison of palliative treatment with best supportive care versus palliative treatment with gemcitabine in combination with best supportive care.

Author: Ragnarson-TennvallG, WilkingN

Improved survival for pancreatic cancer

This study performed a health economic evaluation of palliative treatment with gemcitabine versus standard palliative treatment in patients with locally advanced pancreatic carcinoma, given the short survival of patients with this diagnosis.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

12.

Marimastat as first-line therapy for patients with unresectable pancreatic cancer: a randomized trial.

Author: BramhallS R, RosemurgyA, BrownP D, BowryC, BuckelsJ A,

Dismal prognosis for unresectable pancreatic cancer

The survival rate for patients with unresectable pancreatic cancer is very low (less than 10% at one year and less than 5% at five years). New treatments, including conventional chemotherapy and molecular therapies, are being investigated. This study, the largest of its kind for pancreatic cancer, compared marimastat, a new type of drug, with gemcitabine, a standard chemotherapy agent.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

13.

Adjuvant chemoradiotherapy and chemotherapy in resectable pancreatic cancer: a randomised controlled trial.

Author: NeoptolemosJ P, DunnJ A, StockenD D, AlmondJ, LinkK, BegerH, BassiC, FalconiM, PederzoliP, DervenisC, Fernandez-CruzL, LacaineF, PapA, SpoonerD, KerrD J, FriessH, BüchlerM W,

Improves survival

Adjuvant chemotherapy revealed a potential benefit for survival in pancreatic cancer, justifying further randomised controlled trials.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

The treatment of locally advanced pancreatic cancer: a practice guideline.

Author: EarleCraig C, AgboolaOlusegun, MarounJean, ZurawLisa,

Improved survival

Combined chemotherapy and radiotherapy is recommended for patients with incurable, locally advanced, unresectable but nonmetastatic pancreatic cancer.

GuidelineRecommendations and best practices developed by experts for healthcare professionals to refer to when making clinical judgments and providing care.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Practice GuidelineGuidelines and recommendations for the diagnosis and treatment of specific medical conditions in medical practice.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

15.

[Chemotherapy for advanced or metastatic pancreatic cancer: analysis of 43 randomized trials in 3 decades (1974-2002)].

Author: FungMan C, TakayamaShimako, IshiguroHiroshi, SakataTohru, AdachiSusumu, MorizaneToshio

Pancreatic cancer treatment

Gemcitabine was shown to improve survival and clinical benefit responses better than 5-FU and other new agents in the treatment of advanced pancreatic cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Japanese

16.

Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer.

Author: YipD, KarapetisC, StricklandA, SteerC B, GoldsteinD

Improved quality of life
Prolonged survival
Toxicity

Chemotherapy improved survival in patients with advanced pancreatic cancer, while combination chemotherapy did not show an advantage over single-agent chemotherapy. Chemoradiation treatment was associated with more toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

17.

Primary resection versus neoadjuvant chemoradiation followed by resection for locally resectable or potentially resectable pancreatic carcinoma without distant metastasis. A multi-centre prospectively randomised phase II-study of the Interdisciplinary Working Group Gastrointestinal Tumours (AIO, ARO, and CAO).

Author: BrunnerThomas B, GrabenbauerGerhard G, MeyerThomas, GolcherHenriette, SauerRolf, HohenbergerWerner

Improved ductal pancreatic cancer treatment
Ductal pancreatic cancer

Treating ductal pancreatic cancer with surgery alone hasn't shown good results, so combination therapies are needed. Giving chemotherapy and radiation before surgery (neoadjuvant therapy) is more effective than giving these treatments after surgery because it can make the cancer easier to remove completely and reduce spread to lymph nodes. Neoadjuvant therapy is also better tolerated, allowing more patients to receive this combination treatment. Overall survival rates appear to be higher in studies using neoadjuvant therapy compared to studies using treatment after surgery.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

18.

A randomized phase 2 trial of neoadjuvant chemotherapy in resectable pancreatic cancer: gemcitabine alone versus gemcitabine combined with cisplatin.

Author: PalmerDaniel H, StockenDeborah D, HewittHelen, MarkhamCatherine E, HassanA Bassim, JohnsonPhilip J, BuckelsJohn A C, BramhallSimon R

Improved pancreas cancer treatment
Pancreas cancer

Survival rates for people with pancreatic cancer after surgery are still low, but giving chemotherapy after surgery (adjuvant) improves outcomes. However, many patients don't receive all their prescribed chemotherapy. Giving chemotherapy before surgery (neoadjuvant) might improve treatment completion rates, shrink tumors before surgery, and potentially kill microscopic cancer cells that have spread. This study compared different chemotherapy regimens that include gemcitabine to identify the most promising treatment for future research on neoadjuvant therapy.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

Excess premature (3-month) mortality in advanced pancreatic cancer could be related to fatal vascular thromboembolic events. A hypothesis based on a systematic review of phase III chemotherapy studies in advanced pancreatic cancer.

Author: SgourosJoseph, MaraveyasAnthony

Cancer treatment
Short survival

A review of the literature suggests that survival curves for advanced pancreatic cancer may reflect a substantial survival shortfall.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

20.

The role of adjuvant chemotherapy for patients with resected pancreatic cancer: systematic review of randomized controlled trials and meta-analysis.

Author: BoeckStefan, AnkerstDonna Pauler, HeinemannVolker

Prolonged survival

Adjuvant chemotherapy following resection of pancreatic cancer may prolong disease-free survival and moderately increase overall survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

21.

Survival following curative resection for pancreatic ductal adenocarcinoma. A systematic review of the literature.

Author: GarceaGiuseppe, DennisonAshley R, PattendenClare J, NealChristopher P, SuttonChristopher D, BerryDavid P

Pancreatic cancer is a deadly disease, with only about 15-20% of patients having resectable tumors, and most dying within 7 years of surgery. Understanding factors that may influence outcomes after surgery is essential for optimizing treatment options.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

22.

Pancreaticoduodenectomy (classic Whipple) versus pylorus-preserving pancreaticoduodenectomy (pp Whipple) for surgical treatment of periampullary and pancreatic carcinoma.

Author: DienerM K, HeukauferC, SchwarzerG, SeilerC M, AntesG, BuchlerM W, KnaebelH P

Improved pancreatic cancer treatment
Pancreatic cancer

Pancreatic cancer is a major cause of cancer deaths. The standard treatments for early-stage pancreatic cancer are either a Whipple procedure or a pylorus-preserving pancreaticoduodenectomy, but it's unclear which is better in terms of survival, complications, and quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

23.

DISPACT trial: a randomized controlled trial to compare two different surgical techniques of DIStal PAnCreaTectomy - study rationale and design.

Author: DienerM K, KnaebelH P, WitteS T, RossionI, KieserM, BuchlerM W, SeilerC M,

Improved pancreatic cancer
Pancreatic fistulas

The optimal surgical strategy for pancreatic resection needs to be identified.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

24.

WITHDRAWN: Chemotherapy and radiotherapy for inoperable advanced pancreatic cancer.

Author: YipDesmond, KarapetisChristos, StricklandAndrew, SteerChristopher B, GoldsteinDavid

Improved Survival
Increased Toxicity

Chemotherapy significantly reduced one-year mortality in patients with advanced pancreatic cancer compared to best supportive care. Chemoradiation also improved one-year survival compared to best supportive care, but with higher toxicity.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

25.

WITHDRAWN: Pancreaticoduodenectomy (classic Whipple) versus pylorus-preserving pancreaticoduodenectomy (pp Whipple) for surgical treatment of periampullary and pancreatic carcinoma.

Author: DienerMarkus K, HeukaeuferChristina, SchwarzerGuido, SeilerChristoph M, AntesGerd, KnaebelHanns-Peter, BüchlerMarkus W

Pancreatic cancer treatment

Pancreatic cancer is a deadly disease, and while surgery is the standard treatment for tumors that can be removed, it's unclear which of the two main procedures, Whipple or pylorus-preserving pancreaticoduodenectomy, is better in terms of survival, complications, and quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

26.

Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma.

Author: DienerMarkus K, FitzmauriceChristina, SchwarzerGuido, SeilerChristoph M, AntesGerd, KnaebelHanns-Peter, BüchlerMarkus W

Pancreatic cancer treatment

Pancreatic cancer is a leading cause of cancer death. For tumors that can be removed with surgery, the two standard options are the Whipple procedure (CW) or pylorus-preserving pancreaticoduodenectomy (PPW). The best procedure in terms of survival, complications, and quality of life is not definitively known.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

27.

Adjuvant gemcitabine versus NEOadjuvant gemcitabine/oxaliplatin plus adjuvant gemcitabine in resectable pancreatic cancer: a randomized multicenter phase III study (NEOPAC study).

Author: HeinrichStefan, PestalozziBernhard, LesurtelMickael, BerrevoetFrederik, LaurentStéphanie, DelperoJean-Robert, RaoulJean-Luc, BachellierPhillippe, DufourPatrick, MoehlerMarkus, WeberAchim, LangHauke, RogiersXavier, ClavienPierre-Alain

Improved pancreatic cancer survival

This study discusses the use of neoadjuvant chemotherapy in treating pancreatic cancer. While adjuvant chemotherapy has proven beneficial, it is not always feasible for all patients due to surgical morbidity. Neoadjuvant chemotherapy offers a safe and effective alternative and may improve patient nutritional status.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

28.

Neoadjuvant therapy in pancreatic adenocarcinoma: a meta-analysis of phase II trials.

Author: AssifiM Mura, LuXuyang, EiblGuido, ReberHoward A, LiGang, HinesO Joe

Improved GI cancer outcomes

This meta-analysis examines the effectiveness of neoadjuvant treatment for resectable and borderline/unresectable pancreatic adenocarcinoma, based on phase II trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

29.

A decision model of therapy for potentially resectable pancreatic cancer.

Author: VanHoutenJacob P, WhiteRebekah R, JacksonGretchen Purcell

Pancreatic cancer treatment
Treatment mortality

Neoadjuvant chemoradiation is favored over initial surgery for potentially resectable pancreatic cancer, with expected values of 18.6 and 17.7 mo, respectively. The decision is sensitive to the probability of tumor resectability and chemoradiation mortality.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.

Language : English

30.

[Radically resected pancreatic cancer and adjuvant treatment. A review of the literature].

Author: DrudiFabrizio, TassinariDavide, GiulianiJacopo, RidolfiClaudio, GianniLorenzo, TamburiniEmiliano, FantiniManuela, SantelmoCarlotta, BarzottiEleonora, LottiNadia, RavaioliAlberto

Disease-free survival
Improved survival
Toxicity

Adjuvant therapy is a standard treatment for patients who have had pancreatic cancer surgery. This study will review the evidence on the use of chemotherapy and chemoradiotherapy after surgery, focusing on the effectiveness and toxicity of different treatment options.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : Italian

31.

Adjuvant chemotherapy with gemcitabine and long-term outcomes among patients with resected pancreatic cancer: the CONKO-001 randomized trial.

Author: OettleHelmut, NeuhausPeter, HochhausAndreas, HartmannJörg Thomas, GellertKlaus, RidwelskiKarsten, NiedergethmannMarco, ZülkeCarl, FahlkeJörg, ArningMichael B, SinnMarianne, HinkeAxel, RiessHanno

Disease-free survival improvement
Overall survival improvement

Adjuvant gemcitabine treatment for 6 months compared with observation alone resulted in increased overall survival and disease-free survival in patients with macroscopic complete removal of pancreatic cancer.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

32.

Resection versus other treatments for locally advanced pancreatic cancer.

Author: GurusamyKurinchi Selvan, KumarSenthil, DavidsonBrian R, FusaiGiuseppe

Pancreatic cancer treatment

Pancreatic cancer is an aggressive disease. Surgery is the only treatment that offers the chance for long-term survival. However, some people with advanced cancer have tumors that have spread to nearby structures like blood vessels. Removing these structures during surgery is often avoided due to the risk of complications, leaving many patients with only palliative care. This study suggests that surgery to remove the pancreas and involved blood vessels could be an alternative to palliative care for people with advanced pancreatic cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

33.

Systematic review of novel ablative methods in locally advanced pancreatic cancer.

Author: KeaneMargaret G, BramisKonstantinos, PereiraStephen P, FusaiGiuseppe K

Pancreatic cancer treatment

Pancreatic cancer that cannot be surgically removed has a poor outlook, with current treatment options limited. New approaches, such as using heat or lasers to destroy cancer cells (ablative therapies), are being explored as potential alternatives. While initial studies show promise in improving survival, more research is needed, especially randomized trials, to confirm these benefits.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, N.I.H., ExtramuralResearch funding provided by the NIH to external research institutions and researchers.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

34.

Systematic review of minimally invasive ablation treatment for locally advanced pancreatic cancer.

Author: IerardiAnna Maria, LucchinaNatalie, PetrilloMario, FloridiChiara, PiacentinoFilippo, BacuzziAlessandro, FonioPaolo, FontanaFederico, FugazzolaCarlo, BruneseLuca, CarrafielloGianpaolo

Improved ablation safety
Promising results for inoperable cases
Significant morbidity
Significant mortality

Ablation techniques are being increasingly used for treating inoperable pancreatic cancer, with promising results. This review discusses the current status of local ablative therapies for advanced pancreatic tumors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

35.

Fixed-dose rate gemcitabine alone or alternating with FOLFIRI.3 (irinotecan, leucovorin and fluorouracil) in the first-line treatment of patients with metastatic pancreatic adenocarcinoma: an AGEO randomised phase II study (FIRGEM).

Author: TrouilloudIsabelle, Dupont-GossardAnne-Claire, MalkaDavid, ArtruPascal, GauthierMélanie, LecomteThierry, AparicioThomas, Thirot-BidaultAnne, LobryCéline, AsnaciosAmani, Manet-LacombeSophie, FeinFrancine, DubreuilOlivier, LandiBruno, ZaananAziz, BonnetainFranck, TaïebJulien

Improved pancreatic cancer treatment

This review explores the potential of a sequential treatment approach alternating irinotecan, fluorouracil, and gemcitabine for patients with metastatic pancreatic cancer. Standard of care regimens currently use irinotecan/fluorouracil-based and gemcitabine-based therapies.

Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

36.

Systematic review of innovative ablative therapies for the treatment of locally advanced pancreatic cancer.

Author: RomboutsS J E, VogelJ A, van SantvoortH C, van LiendenK P, van HillegersbergR, BuschO R C, BesselinkM G H, MolenaarI Q

Improved LAPC treatment

Locally advanced pancreatic cancer (LAPC) carries a poor prognosis. While current palliative (radio)chemotherapy offers minimal survival benefit, this systematic review examines the clinical outcomes of various local ablative therapies as potential new treatment options.

Evaluation StudyResearch that systematically evaluates the effectiveness of a particular program or policy. It measures its outcomes and provides important information for future decision-making.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

37.

Metastases of pancreatic adenocarcinoma: A systematic review of literature and a new functional concept.

Author: CannistràMarco, RuggieroMichele, ZulloAlessandra, SerafiniSimone, GrandeRaffaele, NardoBruno

Improved diagnosis
Improved therapy
High morbidity
High mortality

Pancreatic cancer is a deadly disease, and its prognosis is often determined by the location and number of metastases. This study examines the impact of the "M" parameter (metastasis) on patient outcomes in pancreatic adenocarcinoma.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

38.

Surgical resection of pancreatic head cancer: What is the optimal extent of surgery?

Author: KangMee Joo, JangJin-Young, KimSun-Whe

Improved overall survival
Negative aspects of lymph node metastasis

Extended lymphadenectomy for pancreatic head cancer has not been shown to improve patient survival. Systemic treatment, rather than extensive local surgery, is key to improving outcomes.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

39.

The role of neoadjuvant therapy in pancreatic cancer: a review.

Author: RussoSuzanne, AmmoriJohn, EadsJennifer, DorthJennifer

Pancreatic cancer treatment

There's ongoing debate on whether chemotherapy should be given before surgery (neoadjuvant) or after surgery (adjuvant) for pancreatic cancer. While neoadjuvant therapy has potential benefits, such as delivering treatment sooner, assessing the tumor's response, and increasing the chances of successful surgery, there is no clear evidence supporting it over adjuvant therapy. This review examines various approaches to neoadjuvant treatment, including chemotherapy and radiation therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

40.

Second-line therapy for advanced pancreatic cancer: evaluation of prognostic factors and review of current literature.

Author: CaparelloChiara, VivaldiCaterina, FornaroLorenzo, MusettiniGianna, PasquiniGiulia, CataneseSilvia, MasiGianluca, LencioniMonica, FalconeAlfredo, VasileEnrico

Salvage chemotherapy
Advanced pancreatic cancer

Salvage chemotherapy with modified FOLFIRINOX could be useful for a subgroup of advanced pancreatic cancer patients. Higher CA19.9 levels were associated with worse survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

41.

Adjuvant and neoadjuvant therapies in resectable pancreatic cancer: a systematic review of randomized controlled trials.

Author: D'AngeloFrancesco A, AntolinoLaura, La RoccaMara, PetruccianiNiccolò, MagistriPaolo, AurelloPaolo, RamacciatoGiovanni

Improved overall survival
Increased curability

This systematic review examines randomized controlled trials (RCTs) on adjuvant and neoadjuvant therapies for resectable pancreatic cancer, finding that neoadjuvant approaches should be explored only in clinical trials.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

42.

Pylorus-preserving pancreaticoduodenectomy (pp Whipple) versus pancreaticoduodenectomy (classic Whipple) for surgical treatment of periampullary and pancreatic carcinoma.

Author: HüttnerFelix J, FitzmauriceChristina, SchwarzerGuido, SeilerChristoph M, AntesGerd, BüchlerMarkus W, DienerMarkus K

CW for pancreatic cancer
PPW for pancreatic cancer

Pancreatic cancer is a major cause of death. The standard surgical treatments for tumors that can be removed are the Whipple procedure (CW) and pylorus-preserving pancreaticoduodenectomy (PPW). This study aims to determine which procedure is better in terms of survival, death after surgery, complications, and quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

43.

Invasive treatment of pain associated with pancreatic cancer on different levels of WHO analgesic ladder.

Author: DoboszŁukasz, StefaniakTomasz, DobrzyckaMałgorzata, WieczorekJagoda, FranczakPaula, PtaszyńskaDominika, ZasadaKatarzyna, KanyionPeter

Pancreatic cancer treatment

Pancreatic cancer is a difficult-to-treat disease with a high mortality rate. Pain management often relies on medications. Surgery, such as splanchnicectomy, is typically used as a last resort for pain relief. This study suggests that performing minimally invasive splanchnicectomy earlier in the pain management process may be beneficial in controlling pain long-term.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

44.

Evaluation of Pancreatic Cancer Clinical Trials and Benchmarks for Clinically Meaningful Future Trials: A Systematic Review.

Author: RahibLola, FleshmanJulie M, MatrisianLynn M, BerlinJordan D

Improved survival
None reported

A review of 32 phase 3 clinical trials of advanced pancreatic cancer from the past 25 years shows that only 3 agents or combinations were considered clinically meaningful. The review concludes that applying the benchmark of a 50% improvement in overall survival in phase 2 trials would be a more effective way of predicting a clinically meaningful phase 3 trial.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

45.

Systematic Review of Resection Rates and Clinical Outcomes After FOLFIRINOX-Based Treatment in Patients with Locally Advanced Pancreatic Cancer.

Author: RomboutsSteffi J, WalmaMarieke S, VogelJantien A, van RijssenLennart B, WilminkJohanna W, MohammadNadia Haj, van SantvoortHjalmar C, MolenaarI Quintus, BesselinkMarc G

Downstaged disease
Prolonged survival

FOLFIRINOX is a chemotherapy regimen that has been shown to improve survival in patients with advanced pancreatic cancer. This review examined the effects of FOLFIRINOX in patients with locally advanced pancreatic cancer (LAPC), including its potential to reduce the size of the tumor to the point where it could be surgically removed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

46.

Systematic review on the treatment of isolated local recurrence of pancreatic cancer after surgery; re-resection, chemoradiotherapy and SBRT.

Author: GrootVincent P, van SantvoortHjalmar C, RomboutsSteffi J E, HagendoornJeroen, Borel RinkesInne H M, van VulpenMarco, HermanJoseph M, WolfgangChristopher L, BesselinkMarc G, MolenaarI Quintus

ILR treatment
Pancreatic cancer recurrence

This systematic review investigated treatment options for patients with isolated local recurrence (ILR) after pancreatic cancer resection.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

47.

Treatment of pancreatic insufficiency using pancreatic extract in patients with advanced pancreatic cancer: a pilot study (PICNIC).

Author: ZdenkowskiNicholas, RadvanGeorge, PuglieseLeanna, CharltonJulie, OldmeadowChristopher, FraserAllison, BonaventuraAntonino

This study aimed to determine the feasibility of prescribing pancreatic extract (Creon®) for patients with advanced pancreatic cancer, considering the potential role of pancreatic exocrine insufficiency in contributing to cancer-related cachexia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

48.

Neoadjuvant treatment in pancreatic cancer: Evidence-based medicine? A systematic review and meta-analysis.

Author: D'AngeloFrancesco, AntolinoLaura, FarcomeniAlessio, SirimarcoDario, Kazemi NavaAndrea, De SienaMartina, PetruccianiNiccolò, NigriGiuseppe, ValabregaStefano, AurelloPaolo, RamacciatoGiovanni

Improved survival

This systematic review examines the use of neoadjuvant treatments for non-metastatic pancreatic cancer (PaC). The study explores the effectiveness of these treatments in downstaging tumors, sterilizing systemic disease, selecting patients for surgery, and improving overall survival.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

49.

Neoadjuvant chemotherapy versus surgery first for resectable pancreatic cancer (Norwegian Pancreatic Cancer Trial - 1 (NorPACT-1)) - study protocol for a national multicentre randomized controlled trial.

Author: LaboriKnut Jørgen, LassenKristoffer, HoemDag, GrønbechJon Erik, SøreideJon Arne, MortensenKim, SmaalandRune, SorbyeHalfdan, VerbekeCaroline, DuelandSvein

Pancreatic cancer treatment

Pancreatic cancer is a serious disease. While surgery is the main treatment, chemotherapy given before or after surgery can improve survival. The NorPACT-1 study is investigating whether giving chemotherapy before surgery in people with resectable pancreatic cancer can reduce the number of deaths within one year of starting treatment.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

50.

Clinical Factors as a Component of the Personalized Treatment Approach to Advanced Pancreatic Cancer: a Systematic Literature Review.

Author: SkeltonWilliam Paul, ParekhHiral, StarrJason S, TrevinoJose, CioffiJessica, HughesSteven, GeorgeThomas J

Quality of life
Late diagnosis

Effective management of pancreatic cancer often involves addressing clinical factors that impact patient outcomes. These factors include performance status, nutrition and cachexia, pain, psychological distress, medical comorbidities, advanced age, and treatment selection. Careful consideration of these factors can help optimize patient care and improve quality of life.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

51.

Diagnostic performance of contrast-enhanced ultrasound for pancreatic neoplasms: A systematic review and meta-analysis.

Author: LiXing-Zhao, SongJun, SunZhi-Xia, YangYan-Yan, WangHui

Pancreatic tumor diagnosis
Not specified

Contrast-enhanced ultrasound (CEUS) is a reliable tool for diagnosing benign and malignant pancreatic neoplasms. In a meta-analysis of ten studies, CEUS demonstrated high sensitivity (91%) and specificity (87%) for differentiating benign from malignant pancreatic tumors. CEUS offers good diagnostic accuracy and should be considered as a valuable tool for characterizing pancreatic tumors.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

52.

Systematic review and meta-analysis of prognostic role of splenic vessels infiltration in resectable pancreatic cancer.

Author: CrippaStefano, CirocchiRoberto, MaisonneuvePatrick, PartelliStefano, PergoliniIlaria, TamburrinoDomenico, AleottiFrancesca, ReniMichele, FalconiMassimo

Neoadjuvant treatment selection

This meta-analysis aimed to compare the results of distal pancreatectomy for resectable adenocarcinoma of the pancreatic body-tail with and without splenic vessels infiltration, identifying factors associated with poor survival after surgery.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

53.

Chemotherapy and radiotherapy for advanced pancreatic cancer.

Author: ChinVenessa, NagrialAdnan, SjoquistKatrin, O'ConnorChelsie A, ChantrillLorraine, BiankinAndrew V, ScholtenRob Jpm, YipDesmond

Anti-cancer therapies
PC treatment

Pancreatic cancer is a very serious disease with limited treatment options. This review summarizes all available research on treatments for advanced pancreatic cancer to help patients and doctors make informed decisions.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

55.

Chemotherapy in Pancreatic Cancer: A Systematic Review.

Author: HajatdoostLeva, SedaghatKeyvan, WalkerErin J, ThomasJackson, KosariSam

Improved pancreatic cancer treatment

Pancreatic cancer is a very deadly form of cancer. Chemotherapy is the main treatment for tumors that cannot be surgically removed. This review examined the survival outcomes, including overall survival (OS) and progression-free survival (PFS), from recent clinical trials of different chemotherapy regimens for pancreatic cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

56.

Meta-analysis on resected pancreatic cancer: a comparison between adjuvant treatments and gemcitabine alone.

Author: ChenHua, HeRuizhi, ShiXiuhui, ZhouMin, ZhaoChunle, ZhangHang, QinRenyi

Pancreatic cancer treatment
Recurrence delay
Survival time

This meta-analysis compares the efficacy of adjuvant treatments with gemcitabine monotherapy in patients with resected pancreatic cancer, aiming to clarify the effectiveness of different approaches compared to gemcitabine monotherapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Language : English

57.

Gemcitabine Combined with the mTOR Inhibitor Temsirolimus in Patients with Locally Advanced or Metastatic Pancreatic Cancer. A Hellenic Cooperative Oncology Group Phase I/II Study.

Author: KaravasilisVasilios, SamantasEpaminontas, KoliouGeorgia-Angeliki, Kalogera-FountzilaAnna, PentheroudakisGeorge, VarthalitisIoannis, LinardouHelena, RallisGrigorios, SkondraMaria, PapadopoulosGeorgios, PapatsibasGeorge, SgourosJoseph, GoudopoulouAthina, KalogerasKonstantine T, DervenisChristos, PectasidesDimitrios, FountzilasGeorge

Feasible treatment
Gastrointestinal disorders
Hematological toxicities
Lack of efficacy
Metabolic disorders

The combination of gemcitabine (G) and temsirolimus (T) was feasible in patients with locally advanced or metastatic pancreatic carcinoma (MPC) with manageable side effects. However, the combination lacked clinical efficacy, with a median progression-free survival of 2.69 months and a 6-month progression-free survival rate of 30.9%.

Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Clinical Trial, Phase IIA Phase II trial is a trial that further evaluates the efficacy and safety of a new drug or treatment, whose safety has been confirmed to some extent in a Phase I trial, in a small number of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

59.

Neoadjuvant FOLFIRINOX in Patients With Borderline Resectable Pancreatic Cancer: A Systematic Review and Patient-Level Meta-Analysis.

Author: JanssenQuisette P, BuettnerStefan, SukerMustafa, BeumerBerend R, AddeoPietro, BachellierPhilippe, BaharyNathan, Bekaii-SaabTanios, BaliMaria A, BesselinkMarc G, BooneBrian A, ChauIan, ClarkeStephen, DillhoffMary, El-RayesBassel F, FrakesJessica M, GroseDerek, HoseinPeter J, JamiesonNigel B, JavedAmmar A, KhanKhurum, KimKyu-Pyo, KimSong Cheol, KimSunhee S, KoAndrew H, LacyJill, MargonisGeorgios A, McCarterMartin D, McKayColin J, MellonEric A, MoorcraftSing Yu, OkadaKen-Ichi, PanicciaAlessandro, ParikhParag J, PetersNiek A, RablHans, SamraJaswinder, TinchonChristoph, van TienhovenGeertjan, van VeldhuisenEran, Wang-GillamAndrea, WeissMatthew J, WilminkJohanna W, YamaueHiroki, HomsMarjolein Y V, van EijckCasper H J, KatzMatthew H G, Groot KoerkampBas

BRPC treatment
Diarrhea
Fatigue
Neutropenia

Neoadjuvant FOLFIRINOX showed a favorable median OS, resection rate, and R0-resection rate in BRPC patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

60.

Systemic neoadjuvant chemotherapy in modern pancreatic cancer treatment: a systematic review and meta-analysis.

Author: RangarajanK, PucherP H, ArmstrongT, BatemanA, HamadyZzr

Neoadjuvant therapy
Pancreatic ductal adenocarcinoma treatment

This study analyzed multiple research studies to determine the benefits of using neoadjuvant therapy, treatment given before surgery, for pancreatic cancer that can be surgically removed. While neoadjuvant therapy is a promising approach, its role in this type of cancer is still under debate. This meta-analysis aims to provide a clearer picture of the effectiveness of neoadjuvant therapy for pancreatic cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

62.

The prognostic value of CA19-9 response after neoadjuvant therapy in patients with pancreatic cancer: a systematic review and pooled analysis.

Author: YeChen, SadulaAbuduhaibaier, RenSiqian, GuoXin, YuanMeng, YuanChunhui, XiuDianrong

Improved survival
PC treatment
PC progression

This study investigates the correlation between Carbohydrate antigen 19-9 (CA19-9) response and overall survival (OS) in patients with pancreatic cancer (PC) receiving neoadjuvant therapy.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

63.

Total neoadjuvant FOLFIRINOX versus neoadjuvant gemcitabine-based chemoradiotherapy and adjuvant gemcitabine for resectable and borderline resectable pancreatic cancer (PREOPANC-2 trial): study protocol for a nationwide multicenter randomized controlled trial.

Author: JanssenQ P, van DamJ L, BonsingB A, BosH, BosschaK P, CoeneP P L O, van EijckC H J, de HinghI H J T, KarstenT M, van der KolkM B, PatijnG A, LiemM S L, van SantvoortH C, LoosveldO J L, de Vos-GeelenJ, ZonderhuisB M, HomsM Y V, van TienhovenG, BesselinkM G, WilminkJ W, Groot KoerkampB,

Higher R0 resection rates
Improved survival

Neoadjuvant therapy may improve overall survival in patients with localized pancreatic cancer, but randomized trials are needed to confirm its effectiveness.

Clinical Trial ProtocolA plan for conducting a clinical trial. It describes in detail the purpose, design, methodology, and statistical considerations of the trial, ensuring the transparency and consistency of the trial.
Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

64.

A genetically defined signature of responsiveness to erlotinib in early-stage pancreatic cancer patients: Results from the CONKO-005 trial.

Author: HoyerK, HablesreiterR, InoueY, YoshidaK, BriestF, ChristenF, KakiuchiN, YoshizatoT, ShiozawaY, ShiraishiY, StrieflerJ K, BischoffS, LohneisP, PutterH, BlauO, KeilholzU, BullingerL, PelzerU, HummelM, RiessH, OgawaS, SinnM, DammF

Improved PDAC treatment

Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer with a high rate of recurrence after surgery. This study is looking for ways to predict which patients might respond better to treatment with erlotinib, a drug that blocks a protein called EGFR, which is involved in cancer growth.

Clinical Trial, Phase IIIA Phase III trial is a trial that further rigorously verifies the efficacy and safety of a new drug or treatment, whose efficacy and safety have been confirmed in a Phase II trial, in a large number of patients, and evaluates whether it is superior to existing treatments.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

65.

The role of FOLFIRINOX in metastatic pancreatic cancer: a meta-analysis.

Author: ZhangBeilei, ZhouFengyan, HongJiaze, NgDerry Minyao, YangTong, ZhouXinyu, JinJieyin, ZhouFeifei, ChenPing, XuYunbao

Improved overall survival
Gastrointestinal toxicity
Hematologic toxicity

FOLFIRINOX treatment showed potential benefits for patients with metastatic pancreatic cancer, improving overall survival (OS) rate (0.76) compared to other chemotherapy regimens. While it had no benefit on progression-free survival, FOLFIRINOX demonstrated superior benefits over monochemotherapy (0.59) and combination chemotherapy (0.76). There was no significant difference between FOLFIRINOX and nab-paclitaxel + gemcitabine (0.91). The main adverse events included hematological toxicity and gastrointestinal issues, such as febrile neutropenia, reduced white blood cell count, decreased appetite, and diarrhea.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

66.

The importance of time-to-adjuvant treatment on survival with pancreatic cancer: A systematic review and meta-analysis.

Author: SugumarKavin, HueJonathan J, De La SernaSolanus, RothermelLuke D, OcuinLee M, HardacreJeffrey M, AmmoriJohn B, WinterJordan M

Adjuvant chemotherapy for PDAC
Delayed adjuvant therapy

The timing of adjuvant chemotherapy initiation after surgery for pancreatic ductal adenocarcinoma did not show a clear impact on survival. Further research is needed to investigate the effects of extremely delayed treatment.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

67.

Efficacy of systemic oncological treatments in patients with advanced pancreatic cancer at high risk of dying in the short or medium-term: overview of systematic reviews.

Author: SalazarJosefina, Pérez-BracchiglioneJavier, Salas-GamaKarla, AntequeraAlba, Auladell-RispauAriadna, Dorantes-RomandíaRosario, MeadeAdriana G, Jesús QuintanaMaría, RequeijoCarolina, Rodríguez-GrijalvaGerardo, SanteroMarilina, Acosta-DigheroRoberto, SolàIvan, UrrútiaGerard, Bonfill CospXavier,

Improved quality of life
Improved survival
Death risk
Toxicity

The evidence is uncertain about the benefits of oncological treatments for advanced pancreatic cancer, so its use should be proposed only to selected patients. Further studies are needed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

68.

[Surgical treatment for pancreatic cancer with liver metastasis:exploration and innovation].

Author: ShiS, YuX J

Survival benefits for PCLM

The prognosis for pancreatic cancer patients with liver metastasis (PCLM) is poor. While systematic chemotherapy is the current standard treatment, surgical treatment may offer survival benefits for select patients. This manuscript reviews the progress of surgical treatment for PCLM and looks forward to future opportunities and challenges.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Chinese

69.

Is high-intensity focused ultrasound (HIFU) an option for neoadjuvant therapy for borderline resectable pancreatic cancer patients? - a systematic review.

Author: StanislavovaNadya, KaramanlievMartin, IvanovTsvetomir, YotsovTsanko, ZhouKun, DimitrovDobromir

HIFU
Pancreatic cancer treatment

Pancreatic cancer is one of the deadliest cancers. While treatments have improved, outcomes are still poor. Surgery offers the best chance of survival, but only a small percentage of patients are diagnosed at an early stage when surgery is possible. HIFU (high-intensity focused ultrasound) is a non-invasive treatment that is being studied for pancreatic cancer.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

70.

Antecolic versus retrocolic reconstruction after partial pancreaticoduodenectomy.

Author: HüttnerFelix J, KlotzRosa, UlrichAlexis, BüchlerMarkus W, ProbstPascal, DienerMarkus K

Pancreatic cancer treatment

Pancreatic cancer is a serious disease. Surgery is the standard treatment for tumors in the head of the pancreas, and there are two common approaches for reconnecting the intestines after surgery. This study aims to determine which approach is better for patients.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

71.

Comparative Outcomes of First-Line Chemotherapy for Metastatic Pancreatic Cancer Among the Regimens Used in Japan: A Systematic Review and Network Meta-analysis.

Author: TakumotoYuki, SasaharaYuriko, NarimatsuHiroto, AkazawaManabu

Improved pancreatic cancer treatment

This study compares various first-line chemotherapy regimens for patients with metastatic pancreatic cancer in Japan, including gemcitabine (GEM), FOLFIRINOX, GEM+NPTX, and S-1. While these regimens have been approved, direct comparisons are limited, necessitating further research to determine the most effective treatment approach.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

72.

Intraperitoneal chemotherapy in the management of pancreatic adenocarcinoma: A systematic review and meta-analysis.

Author: FrassiniSimone, CalabrettoFrancesca, GranieriStefano, FugazzolaPaola, ViganòJacopo, FazziniNicola, AnsaloniLuca, CobianchiLorenzo

Improved survival

This systematic review and meta-analysis investigates the effectiveness and safety of intraperitoneal treatments, including CRS + HIPEC, NIPEC, and PIPAC, in the management of pancreatic cancer. The study aims to provide an updated overview of the potential benefits and risks of these treatments in this challenging disease.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

73.

Endoscopic ultrasound-guided injectable therapy for pancreatic cancer: A systematic review.

Author: KaurJyotroop, JaruvongvanichVeeravich, ChandrasekharaVinay

Targeted treatment

This study explores the potential of endoscopic ultrasound (EUS)-guided targeted injection of anti-tumor agents into pancreatic tumors for treating pancreatic ductal adenocarcinoma (PDAC). It highlights the minimally invasive nature of EUS and its potential for localized delivery of therapeutic agents.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

74.

Research advances and treatment perspectives of pancreatic adenosquamous carcinoma.

Author: ZhangWen, ZhangJing, LiangXijun, DingJin

High metastatic potential
Worse prognosis

Pancreatic adenosquamous carcinoma (PASC) is a rare pancreatic malignancy with a worse prognosis than pancreatic ductal adenocarcinoma (PDAC). The pathogenesis and treatment of PASC are not yet fully understood.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

75.

Stereotactic ablative radiotherapy or best supportive care in patients with localized pancreatic cancer not receiving chemotherapy and surgery (PANCOSAR): a nationwide multicenter randomized controlled trial according to a TwiCs design.

Author: DoppenbergD, BesselinkM G, van EijckC H J, IntvenM P W, KoerkampB Groot, KazemierG, van LaarhovenH W M, MeijerinkM, MolenaarI Q, NuyttensJ J M E, van OsR, van SantvoortH C, van TienhovenG, VerkooijenH M, VersteijneE, WilminkJ W, LagerwaardF J, BruynzeelA M E,

Pancreatic cancer treatment
Quality of life

This study explores the potential of stereotactic ablative body radiotherapy (SABR) as a treatment option for patients with localized pancreatic ductal adenocarcinoma (PDAC) who are not candidates for surgery or systemic therapy. Current treatment options for these patients are limited to best supportive care.

Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

76.

Does neoadjuvant treatment in resectable pancreatic cancer improve overall survival? A systematic review and meta-analysis of randomized controlled trials.

Author: Uson JuniorP L S, Dias E SilvaD, de CastroN M, da Silva VictorE, RotherE T, AraújoS E A, BoradM J, MouraF

Improved R0 rates
No DFS improvement
No OS improvement

This systematic review evaluated the association of neoadjuvant treatment and survival outcomes in patients with resectable pancreatic cancer (RPC). Neoadjuvant chemotherapy or chemoradiation does not improve disease-free survival (DFS) or overall survival (OS) in RPC compared to upfront surgery followed by adjuvant treatment. However, neoadjuvant treatment improves R0 resection rates by approximately 20%.

Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

77.

FOLFIRINOX or Gemcitabine-based Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Cancer: A Multi-institutional, Patient-Level, Meta-analysis and Systematic Review.

Author: EshmuminovDilmurodjon, AminjonovBotirjon, PalmRussell F, MalleoGiuseppe, SchmockerRyan K, AbdallahRaëf, YooChanghoon, ShaibWalid L, SchneiderMarcel André, RangelovaElena, ChoiYoo Jin, KimHongbeom, RoseJ Bart, PatelSameer, WilsonGregory C, MaloneySarah, TimmermannLea, SahoraKlaus, RösslerFabian, Lopez-LopezVíctor, BoyerEmanuel, MagginoLaura, MalinkaThomas, ParkJeong Youp, KatzMatthew H G, PrakashLaura, AhmadSyed A, HeltonScott, JangJin-Young, HoffeSarah E, SalviaRoberto, TaiebJulien, HeJin, ClavienPierre-Alain, HeldUlrike, LehmannKuno

Pancreatic cancer treatment

This meta-analysis found that in patients with locally advanced (LAPC) or borderline resectable (BRPC) pancreatic cancer, primary treatment with FOLFIRINOX compared with gemcitabine-based chemotherapy appears to provide a survival benefit for patients that are ultimately unresectable.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

78.

Adjuvant and neoadjuvant approaches in pancreatic cancer.

Author: ConroyThierry, LambertAurélien, DucreuxMichel

Improved overall survival

This review summarizes the current evidence on adjuvant and neoadjuvant treatment approaches for resectable pancreatic cancer. Adjuvant chemotherapy with mFOLFIRINOX remains the standard of care for fit patients. Limited evidence supports the use of neoadjuvant therapy.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

79.

Adjuvant Chemotherapy and Radiotherapy in Resected Pancreatic Ductal Adenocarcinoma: A Systematic Review and Clinical Practice Guideline.

Author: BiagiJames J, CosbyRoxanne, BahlMala, ElfikiTarek, GoodwinRachel, HalletJulie, HirmizKhalid, MahmudAamer

PDAC treatment

This systematic review examines the role of adjuvant treatment (chemotherapy, chemoradiation therapy [CRT], and stereotactic body radiation therapy [SBRT]) for resected pancreatic ductal adenocarcinoma (PDAC). Adjuvant chemotherapy improves survival compared to surgery alone, with mFOLFIRINOX recommended as the optimal regimen. CRT does not offer a survival advantage over chemotherapy and is not recommended. SBRT should only be used in clinical trials.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

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