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Two Randomized, Double-Blind, Split-Face Studies to Compare the Irritation Potential of Two Topical Acne Fixed Combinations Over a 21-Day Treatment Period.

Author: BhatiaNeal, BhattVarsha, MartinGina, PillaiRadhakrishnan

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the tolerability of two acne treatments: clindamycin-benzoyl peroxide 3.75% gel and adapalene 0.3%-benzoyl peroxide 2.5% gel. Clindamycin-benzoyl peroxide was found to be better tolerated than adapalene-benzoyl peroxide, with less irritation and dryness. These findings suggest that clindamycin-benzoyl peroxide might be a better option for treating moderate to severe acne.
Paper Details　
Original Abstract of the Article :
Topical therapy of acne vulgaris (acne) is very common, however cutaneous tolerability can influence patient adherence, and concerns about skin irritation have lead to a number of comparative split-face studies. Advances in formulation technology have provided new fixed combinations with lower conce...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/27272079

データ提供：米国国立医学図書館（NLM）

Topical Acne Treatment: A Balancing Act Between Efficacy and Tolerability

[Topical acne treatment] is a widely practiced approach, but [skin irritation] can significantly impact patient adherence. This study compared the tolerability of two fixed-combination treatments, [clindamycin-BP 3.75% gel and adapalene 0.3%-BP 2.5% gel], in healthy volunteers using a [split-face methodology]. The research focused on evaluating [cutaneous tolerability] over a 21-day period, highlighting the importance of minimizing skin irritation while maintaining therapeutic efficacy.

Clindamycin-BP 3.75% Gel: A More Tolerable Option

The study revealed that [clindamycin-BP 3.75% gel] demonstrated significantly better tolerability than [adapalene 0.3%-BP 2.5% gel] in managing [acne vulgaris]. The findings, based on a [split-face design] and [objective measurements of skin irritation], suggest that [clindamycin-BP 3.75% gel] may be a preferred treatment option for patients with [moderate-to-severe acne].

Choosing the Right Acne Treatment: Prioritizing Tolerability

This study emphasizes the crucial role of [tolerability] in [topical acne treatment]. It highlights the importance of considering [individual patient needs] and [skin sensitivity] when choosing the right treatment. It's essential to remember that [different formulations] can have varying levels of tolerability, and consulting with a dermatologist is crucial for personalized recommendations. Just as camels adapt to the harsh desert environment, we should strive to find acne treatments that are well-suited to our individual needs.

Dr.Camel's Conclusion

Finding the right acne treatment is like searching for a cool spring in the desert; it requires patience and careful consideration. This study sheds light on the importance of tolerability in acne management. By considering the delicate balance between efficacy and tolerability, we can find a treatment that helps us conquer acne without sacrificing our skin's well-being. Always consult with a qualified dermatologist to determine the best approach for your unique needs.
Date :
  1. Date Completed 2017-04-26
  2. Date Revised 2017-04-26
Further Info :

Pubmed ID

27272079

DOI: Digital Object Identifier

S1545961616P0721X

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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