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Nicotine potentiates the effects of haloperidol in animals and in patients with Tourette syndrome.
Author: BlytheM M, FogelsonH M, KlykyloW M, ManderscheidP Z, McConvilleB J, NormanA B, ParkerK W, SanbergP R
Original Abstract of the Article :
Nicotine was found to markedly potentiate haloperidol-induced hypokinesia in rats. Nicotine alone was without effect. Subsequently, concurrent administration of 2 mg nicotine gum to 10 Tourette syndrome patients being treated with haloperidol produced a substantial decrease in tics and improvement o...See full text at original site
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引用元:
https://doi.org/10.1016/0753-3322(89)90186-8
データ提供:米国国立医学図書館(NLM)
Nicotine: A Surprising Ally in the Treatment of Tourette Syndrome?
Tourette syndrome, a neurological disorder characterized by involuntary movements and vocalizations, can be a challenging journey through the desert of discomfort. This study, like a camel caravan embarking on a new route, explores a novel approach to managing Tourette syndrome. Researchers discovered that nicotine, a substance typically associated with tobacco, could potentiate the effects of haloperidol, a medication used to treat Tourette syndrome, in both animal models and human patients. The study observed a significant reduction in tics and improved concentration and attention span in Tourette syndrome patients when nicotine gum was administered concurrently with haloperidol. While the findings are promising, the study also highlighted the importance of managing side effects, particularly nausea and bitter taste.A New Path in the Desert of Tourette Syndrome
This research suggests that nicotine may hold potential as a valuable tool in the treatment of Tourette syndrome. The combination of nicotine with haloperidol appears to enhance the effectiveness of haloperidol, potentially offering a more effective way to manage symptoms. However, as with any new approach, careful monitoring of side effects and a thorough understanding of potential risks are crucial.Navigating the Desert with Tourette Syndrome
Tourette syndrome is a complex disorder, and managing it effectively requires a multi-faceted approach. Working closely with a healthcare professional to develop an individualized treatment plan is essential. This may involve medications, behavioral therapies, and lifestyle modifications tailored to meet individual needs.Dr. Camel's Conclusion
Nicotine, a substance often associated with negative connotations, may hold surprising therapeutic potential in the treatment of Tourette syndrome. This study, like a camel finding a hidden oasis, presents a new path in the desert of Tourette syndrome, offering a glimmer of hope for individuals seeking relief from their symptoms.Date :
- Date Completed 1989-07-25
- Date Revised 2019-10-22
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