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Abuse liability assessment of eslicarbazepine acetate in healthy male and female recreational sedative users: A Phase I randomized controlled trial.

Author: BlumDavid, ChakrabortyBijan, ChengHailong, Levy-CoopermanNaama, SchoedelKerri A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Clinical Trial, Phase IThe first stage of clinical trials in humans. Evaluates the safety, tolerability, and pharmacokinetics of a new drug/treatment.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This Phase I study evaluated the abuse liability of eslicarbazepine acetate (ESL), a once-daily oral antiepileptic drug, compared with alprazolam (ALP) and placebo (PBO) in recreational CNS depressant users.
Paper Details　
Original Abstract of the Article :
Eslicarbazepine acetate (ESL) is a once-daily oral antiepileptic drug for the treatment of partial-onset seizures. Adverse events such as dizziness and somnolence reported in clinical studies suggest that ESL has detectable central nervous system (CNS) effects in addition to its antiepileptic effect...See full text at original site
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引用元：
https://doi.org/10.1016/j.yebeh.2016.05.010

データ提供：米国国立医学図書館（NLM）

Abuse Liability of Eslicarbazepine Acetate

This research delves into the critical field of drug abuse liability. The study utilizes a randomized controlled trial to investigate the potential for abuse of eslicarbazepine acetate (ESL), a commonly prescribed antiepileptic drug. The researchers carefully compared ESL with alprazolam (ALP), a known sedative, and a placebo (PBO) to determine its relative abuse liability in individuals who use CNS depressants recreationally. They uncovered valuable insights into ESL's central nervous system (CNS) effects, revealing a potential for abuse among this specific population. The study's findings have important implications for the prescribing and monitoring of ESL in clinical practice.

Understanding the Potential for Abuse

The study's findings suggest that ESL, while effective in treating seizures, may also exhibit CNS effects that could lead to abuse, particularly in individuals who already use recreational CNS depressants. The authors suggest that further research is needed to better understand the risks associated with ESL use in different populations.

Implications for Safe Use

This research highlights the importance of careful monitoring and open communication between patients and their healthcare providers regarding the potential for abuse of prescription medications. It reminds us that even medications designed to treat serious conditions can have unintended consequences, especially when used by individuals with pre-existing substance use issues.

Dr.Camel's Conclusion

This research study, like a shimmering oasis in the vast desert of pharmacology, provides valuable insights into the potential for abuse of a commonly prescribed drug. The findings remind us that we must be vigilant in our approach to prescription medications, considering individual patient factors and potential risks to ensure safe and effective treatment.

Date :
  1. Date Completed 2017-09-04
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27315134

DOI: Digital Object Identifier

10.1016/j.yebeh.2016.05.010

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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