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In vitro spectrum of pexiganan activity; bactericidal action and resistance selection tested against pathogens with elevated MIC values to topical agents.
Author: FarrellDavid J, FlammRobert K, JonesRonald N, RhombergPaul R
Original Abstract of the Article :
Pexiganan, in Phase 3 clinical development for topical use, exhibited bactericidal activity in vitro against Gram-positive and -negative isolates and was also shown to have a low potential for resistance development in broth serial passage experiments. Susceptibility studies were performed against b...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。
引用元：
https://doi.org/10.1016/j.diagmicrobio.2016.06.012
データ提供：米国国立医学図書館（NLM）
Pexiganan: A Novel Antimicrobial Agent with Broad Spectrum Activity and Low Resistance Potential
This study investigates the antimicrobial properties of [pexiganan], a promising new drug candidate for topical use. The research team evaluated [pexiganan]'s bactericidal activity against a wide range of Gram-positive and Gram-negative bacteria, including isolates with elevated MIC values to common topical agents. The findings reveal [pexiganan]'s potential as a potent antimicrobial agent with a low propensity for resistance development, offering a glimmer of hope in the fight against antibiotic resistance.
The Rise of Antibiotic Resistance: A Global Challenge
This research highlights the growing concern of [antibiotic resistance] and the urgent need for new antimicrobial agents like [pexiganan]. The study found that [pexiganan] demonstrates bactericidal activity against a broad spectrum of bacteria, including isolates that are resistant to other commonly used topical agents. This breakthrough could provide a crucial weapon in the ongoing battle against drug-resistant pathogens.
Staying Ahead of the Curve: New Antimicrobials in the Fight Against Resistance
The development of new antimicrobial agents like [pexiganan] is crucial in addressing the global challenge of [antibiotic resistance]. [Pexiganan]'s broad spectrum activity and low resistance potential make it a promising candidate for treating a wide range of infections. Maintaining vigilance in infection control measures and the responsible use of antibiotics are vital to combat this growing threat.
Dr. Camel's Conclusion
Imagine a vast desert where every grain of sand represents a different bacteria. In this vast landscape, [pexiganan] acts like a vigilant oasis, offering protection from the encroaching threat of antibiotic resistance. This research underscores the importance of continuous innovation in the fight against drug-resistant pathogens, a battle we must win to safeguard our health and well-being.
Date :
- Date Completed 2017-02-13
- Date Revised 2017-11-16
Further Info :
Related Literature
English
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