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Suivi thérapeutique pharmacologique du felbamate.

Author: , Bentué-FerrerDanièle, TributOlivier, VerdierMarie-Clémence

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Felbamate, a medication used for epilepsy, has linear kinetics and is metabolized in the liver. While therapeutic drug monitoring (TDM) is suggested due to the concentration-dependent efficacy and toxicity, the therapeutic range is not well-established. The risk of potentially fatal side effects limits its use despite its effectiveness.
Paper Details　
Original Abstract of the Article :
Felbamate is a derivative of meprobamate used in second-line partial epilepsy and in the Lennox-Gastaut syndrome. Felbamate is well absorbed and has linear kinetics: Cmax and AUC increasing linearly with dose. The metabolism takes place in the liver. Metabolites represent 40 to 60% of excretion and ...See full text at original site
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引用元：
https://doi.org/10.2515/therapie/2009068

データ提供：米国国立医学図書館（NLM）

Felbamate: A Treatment with a Complex Desert Landscape

Epilepsy is a neurological disorder that can have a profound impact on individuals' lives. This research explores the use of felbamate, a medication used to treat epilepsy, and highlights the importance of therapeutic drug monitoring (TDM) to ensure safe and effective treatment. Think of this as a camel caravan navigating a desert with unpredictable landscapes, where understanding the terrain is crucial for a successful journey.

Therapeutic Drug Monitoring: A Guide Through the Desert

The study emphasizes that felbamate has a complex pharmacokinetic profile, meaning that its levels in the body can vary significantly. This makes TDM essential to adjust dosage based on individual patient needs and to minimize the risk of serious side effects. This is similar to a camel caravan adjusting its pace and route based on the shifting desert sands to ensure a safe and efficient journey.

Health Implications and Everyday Applications

This research highlights the importance of working closely with your doctor and pharmacist to ensure the safe and effective use of medications like felbamate. It emphasizes the need for ongoing monitoring to adjust treatment plans and minimize potential risks. Just as a camel needs constant attention and care while crossing the desert, those taking felbamate need close medical supervision to ensure their well-being.

Dr. Camel's Conclusion

This research underscores the importance of careful monitoring and personalized treatment approaches for individuals with epilepsy. Just as a camel needs a skilled guide to navigate the complex and unpredictable desert, patients taking felbamate need vigilant medical supervision to ensure safe and effective treatment.

Date :
  1. Date Completed 2016-07-12
  2. Date Revised 2016-07-09
Further Info :

Pubmed ID

27392921

DOI: Digital Object Identifier

10.2515/therapie/2009068

Related Literature

Article Analysis
・Side Effects of meprobamate
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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