Side Effects of meprobamate: A Synthesis of Findings from 17 Studies

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This information is not medical advice and is not a substitute for diagnosis or treatment by a physician.Data sources and disclaimers (data limitations, copyright, etc.)The analysis on "Side Effects of meprobamate: A Synthesis of Findings from 17 Studies" on this page is based on PubMed data provided by the U.S. National Library of Medicine (NLM). However, NLM does not endorse or verify these analyses.

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Original Abstract of the Article

Major Research Findings

Meprobamate is a medication that can help to relax muscles. It is used to treat anxiety and sleep disorders, but it is important to be aware of its potential side effects.

For example, a study in reported skin side effects associated with meprobamate.

A study in 14 suggested that meprobamate may inhibit ovulation. Also, a study in 1 reported that inhaling a drug containing meprobamate can cause caustic damage to the airways.

A study in 9 suggested a link between meprobamate use and an increased risk of non-Hodgkin's lymphoma. Also, a study in 2 suggested that meprobamate may cause visual abnormalities.

These research findings indicate that meprobamate may cause several side effects.

Reasons for Side Effects

The reasons for meprobamate's side effects are not yet fully understood. However, it is believed that the side effects are caused by meprobamate's effect on the central nervous system.

Common Side Effects

Drowsiness

The most common side effect of meprobamate is drowsiness. This side effect is thought to occur because meprobamate suppresses brain activity. Studies in 14 , 6 , , and 15 indicate that meprobamate is used as a sleep aid, so side effects such as drowsiness are considered common.

Dizziness

Meprobamate can cause dizziness. This is thought to occur because meprobamate affects the part of the brain that controls balance. The study in suggests that meprobamate may affect the part of the brain that controls balance.

Unsteadiness

Meprobamate can cause unsteadiness. This is thought to occur because meprobamate relaxes muscle tension. A study in 14 shows that meprobamate has a muscle relaxing effect. From this, it can be seen that meprobamate may cause unsteadiness.

Gastrointestinal Side Effects

Meprobamate can cause gastrointestinal side effects such as nausea, vomiting, and constipation. This is thought to occur because meprobamate affects the functioning of the gastrointestinal tract. The study in 7 suggests that meprobamate may cause gastrointestinal side effects. Also, a study in 6 reports that meprobamate may affect the gastrointestinal tract.

Allergic Reactions

Meprobamate can cause allergic reactions. This is thought to occur because the body has an allergic reaction to the ingredients contained in meprobamate. The study in 7 suggests that meprobamate may cause allergic reactions.

Dependence

Meprobamate can be addictive. This is thought to occur because taking meprobamate for long periods of time can cause the body to become accustomed to it, weakening the effect of the drug. Therefore, it is important to take the appropriate amount of meprobamate according to the doctor's instructions. The study in 8 reports a case of meprobamate abuse. As meprobamate can be addictive, it is important to take the appropriate amount according to the doctor's instructions.

Other Side Effects

Meprobamate may cause various other side effects besides those listed above. It is important to consult a doctor before taking meprobamate and understand the risks of side effects.

Side Effect Measures

Drowsiness

If you experience severe drowsiness from taking meprobamate, consult your doctor. Your doctor may adjust the amount of meprobamate you are taking or switch to a different medication. Also, if you are prone to drowsiness, you need to be careful, such as avoiding driving or operating machinery. The study in 15 suggests that meprobamate may cause side effects such as drowsiness. If these side effects are severe, consult your doctor.

Dizziness

While taking meprobamate, you may experience dizziness. If you feel dizzy, get up and walk slowly and be careful not to fall. The study in suggests that meprobamate may cause dizziness. If you feel dizzy, get up and walk slowly and be careful not to fall.

Gastrointestinal Side Effects

While taking meprobamate, you may experience gastrointestinal side effects such as nausea, vomiting, and constipation. If you are concerned about these side effects, consult your doctor. The study in 6 suggests that meprobamate may cause gastrointestinal side effects. If you are concerned about these side effects, consult your doctor.

Allergic Reactions

If you experience an allergic reaction while taking meprobamate, consult your doctor immediately. The study in 7 suggests that meprobamate may cause allergic reactions. If you experience an allergic reaction, consult your doctor immediately.

Dependence

When you stop taking meprobamate, consult your doctor. Your doctor may adjust the amount of meprobamate you are taking gradually. Also, withdrawal symptoms may occur when you stop taking meprobamate. If withdrawal symptoms occur, consult your doctor. The study in 8 reports a case of meprobamate abuse. As meprobamate can be addictive, it is important to take the appropriate amount according to the doctor's instructions.

Comparison of Studies

Commonalities of Studies

Many studies have shown that meprobamate can cause a number of side effects. These side effects include drowsiness, dizziness, gastrointestinal problems, and others. It has also been shown that meprobamate may be addictive. The studies in , 14 , 1 , 9 , 2 , , 6 , 7 , and 8 report on the side effects of meprobamate.

Differences between Studies

The severity and type of meprobamate side effects vary depending on the individual's constitution and dosage. Also, the side effects of meprobamate can change due to interactions with other drugs. The study in 4 is a study on the interaction between meprobamate and other drugs.

Notes on Application to Real Life

Meprobamate is an effective drug for treating anxiety and sleep disorders, but it is known to have some side effects. If you are taking meprobamate, talk to your doctor about the risks of side effects. Also, while taking meprobamate, avoid activities that require caution, such as driving or operating machinery. The study in 16 is a study on the relationship between the use of drugs and the risk of falls in the elderly. Elderly people taking meprobamate need to be careful of falls.

Limitations of Current Research

Research on the side effects of meprobamate is still insufficient. In particular, research on the long-term effects of meprobamate is lacking. Further research is needed on the long-term effects of meprobamate.

Future Research Directions Needed

Studies to evaluate the long-term effects of meprobamate are needed. Also, research is needed to develop ways to reduce the side effects of meprobamate. Furthermore, research on the interaction between meprobamate and other drugs is also needed.

Conclusion

Meprobamate is an effective drug for treating anxiety and sleep disorders, but it is known to have some side effects. If you are taking meprobamate, talk to your doctor about the risks of side effects. Also, further research is needed on the long-term effects of meprobamate.

Literature analysis of 17 papers
Positive Content
7
Neutral Content
1
Negative Content
9
Article Type
1
1
1
3
17
1.

[Unsuspected danger of a medicinal preparation].

Author: GohyS, QuenneryS, PietersT, WeynandB, LiistroG

Caustic airway damage

Inhalation of medications can lead to airway obstruction and even caustic damage. This case report highlights the need to be familiar with the chemical properties of medications when prescribing them to patients at risk of aspiration.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

2.

Transient visual anomalies associated with drug treatment for spastic colon.

Author: ApplegateR A, SorianoT, PerryC, ElamJ

Color discrimination loss
Dark adaptation delay

Two previously unreported adverse effects of meprobamate and tridihexethyl chloride therapy for a spastic colon were identified: a diffuse loss of color discrimination and increased time to complete dark adaptation.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Multidrug toxicity involving sumatriptan.

Author: KnittelJessica L, VorceShawn P, LevineBarry, HughesRhome L, BosyThomas Z

Acute mixed drug toxicity
Multidrug fatality

This report describes a multidrug fatality involving sumatriptan, highlighting the potential risks associated with high doses of the medication.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

6.

Tranquilizers, analgetics and antidepressants in patients treated with hemodialysis.

Author: ForyckiZ, MartensF, ThalhoferS, IbeK

No perfect rules for dosage exist for tranquilizers, analgetics and antidepressants in patients on hemodialysis.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

Abusive prescription of psychostimulants: a study of two cases.

Author: Pélissier-AlicotAnne-Laure, Piercecchi-MartiMarie-Dominique, BartoliChristophe, KuhlmannErika, CoiffaitPhilippe-Emmanuel, SanvoisinAlain, GiocantiDominique, LéonettiGeorges

Abuse potential
Psychostimulant side effects

Psychostimulants have serious side effects and abuse potential, limiting their use to conditions like obesity, narcolepsy, and ADHD. This report details two cases of inappropriate psychostimulant prescriptions. A woman taking fenproporex for weight loss experienced withdrawal symptoms when the drug was discontinued. Another woman prescribed multiple medications for sleep problems was found dead at home. These cases highlight the dangers of psychostimulants and underscore the importance of adhering to prescription guidelines.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

9.

Risks of non-Hodgkin's lymphoma, multiple myeloma, and leukemia associated with common medications.

Author: DoodyM M, LinetM S, GlassA G, CurtisR E, PotternL M, RushB B, BoiceJ D, FraumeniJ F, FriedmanG D

Hematopoietic malignancy
Leukemia
Lymphoproliferative malignancy

Use of amphetamines, lidocaine, and meprobamate was associated with an increased risk of non-Hodgkin's lymphoma. Chloramphenicol was associated with a decreased risk of total leukemia.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, U.S. Gov't, P.H.S.Research funding provided by the Public Health Service (PHS).

Language : English

10.

Muscle relaxants for pain management in rheumatoid arthritis.

Author: RichardsBethan L, WhittleSamuel L, BuchbinderRachelle

Pain management

Muscle relaxants are widely used as adjuncts in managing chronic musculoskeletal pain, but evidence supporting their effectiveness is limited.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Language : English

12.

[Therapeutic drug monitoring of felbamate].

Author: TributOlivier, Bentué-FerrerDanièle, VerdierMarie-Clémence,

Epilepsy treatment
Aplastic anemia
Fatal side effects
Liver failure

This study discusses the use of felbamate, a meprobamate derivative, in the treatment of epilepsy. Felbamate is well absorbed and has linear kinetics, but its use is limited by potentially fatal side effects, such as aplastic anemia and acute liver failure, which are dose-independent.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : French

14.

[Chronologic and quantitative modalities of luteinization and ovulation in the female rat exposed to FSH action at the beginning of 4-day cycles].

Author: GeigerJ M, ChateauD

Ovulation inhibition

FSH treatment in rats resulted in superovulation and increased corpora lutea formation. Meprobamate or pentobarbitone injections blocked ovulation and luteinization, suggesting that FSH treatment does not alter the timing of the critical period for ovulation.

English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : French

15.

Formation of meprobamate from carisoprodol is catalysed by CYP2C19.

Author: DalénP, AlvanG, WakelkampM, OlsenH

Analgesic
Muscle relaxant
Drowsiness
Hypotension

Poor metabolizers of mephenytoin have a lower capacity to metabolize carisoprodol and may have an increased risk of developing side effects such as drowsiness and hypotension if treated with ordinary doses.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

16.

Medication use and increased risk of falls in hospitalized elderly patients: a retrospective, case-control study.

Author: RhalimiMounir, HelouRafik, JaeckerPierre

Increased fall risk

Zolpidem, meprobamate, and calcium channel antagonists were associated with an increased risk of falls in recently hospitalized older people.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

17.

Calcium-channel-blocking agent in the treatment of acute alcohol withdrawal--caroverine versus meprobamate in a randomized double-blind study.

Author: KoppiS, EberhardtG, HallerR, KönigP

Reduced drug loading
Reduced sedative side effects

Caroverine, a group B Ca2+ channel blocker, was found to be as effective as meprobamate in treating alcohol withdrawal symptoms in 22 patients. Caroverine was associated with less sedation than meprobamate, and may be a better choice for treatment.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

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