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Rifampicin resistance after treatment for latent tuberculous infection: a systematic review and meta-analysis.

Author: GetahunH, MatteelliA, den BoonS

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

Treating latent tuberculosis infection (LTBI) reduces the risk of developing active tuberculosis (TB). Shorter treatment regimens that include rifamycin drugs have been shown to be as effective as longer treatment with isoniazid, and have fewer side effects and a higher completion rate. However, it is unclear whether using rifamycins for prevention increases resistance to these drugs.
Paper Details　
Original Abstract of the Article :
Treatment for latent tuberculous infection (LTBI) reduces the risk of tuberculosis (TB) disease. Shorter, rifamycin-containing regimens have been shown to be as effective as 6 months of isoniazid and superior with regard to safety and completion rate. It is unknown whether preventive therapy with ri...See full text at original site
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難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
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引用元：
https://pubmed.ncbi.nlm.nih.gov/27393541

データ提供：米国国立医学図書館（NLM）

Rifampicin Resistance in Latent Tuberculous Infection Treatment

Tuberculosis (TB) is a global health challenge, and latent TB infection (LTBI) is a silent threat that can progress to active disease. Researchers are constantly searching for new and effective ways to treat LTBI. This study delves into the potential risk of rifampicin resistance developing after treatment for LTBI. It's a question that lingers like a desert mirage – is there a hidden danger lurking in the shadows of this seemingly effective treatment?

Rifampicin: A Powerful Weapon with Potential Drawbacks

The study sheds light on the effectiveness of rifampicin-containing regimens for treating LTBI. While they've proven to be effective, there's a concern that these regimens might inadvertently increase resistance to rifamycins. This would be like a desert oasis suddenly turning into a barren wasteland, leaving us with fewer options for treating TB.

Preventing Resistance: A Desert of Challenges

The researchers highlight the importance of understanding the potential risks associated with rifampicin-containing regimens for LTBI. Like navigating a vast and unforgiving desert, we need to carefully consider all possible outcomes and develop strategies to prevent resistance. This might involve exploring alternative treatment options, optimizing treatment duration, and closely monitoring patients for signs of resistance.

Dr. Camel's Conclusion

This study emphasizes the need for ongoing research to ensure the long-term effectiveness of rifampicin-containing regimens for LTBI. We need to be mindful of the potential for resistance and develop strategies to mitigate this risk. In the ever-shifting sands of medical research, vigilance and adaptation are crucial for conquering the challenges of TB.
Date :
  1. Date Completed 2018-01-23
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

27393541

DOI: Digital Object Identifier

EMS74247

SNS
PICO Info
in preparation
Languages

English

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