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Protease Inhibitors Drug Resistance Mutations in Turkish Patients with Chronic Hepatitis C.

Author: AkhanSila, AyazCelal, AygenBilgehan, AyniogluAynur, DemirturkNese, ErsozGülden, InanDilara, KarakeciliFaruk, KetenDerya, KoculuSafiye, KorkmazFatime, KoseŞükran, MistikResit, Sargin AltunokElif, SayanMurat, Tekin KorukSuda, TunaNazan, UralOnur, YaziciSaadet, YildirmakTaner, YildizOrhan

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Drug resistance to protease inhibitors (PIs) is a concern in hepatitis C (HCV) treatment, especially in regions where resistance-associated variants (RAVs) may be prevalent before treatment. This study highlights the need for further research to investigate HCV drug resistance to oral antivirals in Turkey.
Paper Details　
Original Abstract of the Article :
Drug resistance development is an expected problem during treatment with protease inhibitors (PIs), this is largely due to the fact that Pls are low-genetic barrier drugs. Resistance-associated variants (RAVs) however may also occur naturally, and prior to treatment with Pls, the clinical impact of ...See full text at original site
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引用元：
https://doi.org/10.1016/j.ijid.2016.07.003

データ提供：米国国立医学図書館（NLM）

Investigating Protease Inhibitor Drug Resistance in Turkish Hepatitis C Patients

This study explores the development of drug resistance to protease inhibitors (PIs) in Turkish patients with chronic hepatitis C. The authors note that drug resistance is a common issue with PIs, a class of medications used to treat hepatitis C, due to their low genetic barrier. They aim to investigate the prevalence of resistance-associated variants (RAVs) in Turkish patients.

Understanding Drug Resistance in Hepatitis C

The study focuses on the clinical impact of basal resistance, which refers to the presence of RAVs before treatment with PIs. It highlights the need for ongoing research to understand the mechanisms of resistance development and to develop strategies for preventing or mitigating it.

Considerations for Hepatitis C Treatment

This research underscores the importance of individualized treatment plans for hepatitis C patients, taking into account factors such as genetic predisposition and prior treatment history. As a camel who has witnessed the adaptability of life in challenging environments, I am fascinated by the ongoing battle between viruses and the medications designed to combat them.

Dr.Camel's Conclusion

This study highlights the complexities of treating chronic viral infections like hepatitis C. It emphasizes the importance of ongoing research to develop new therapies and to optimize existing treatments to overcome the challenge of drug resistance. As we navigate the vast desert of medical research, we must remain persistent and resourceful in our quest for effective treatments for all patients.
Date :
  1. Date Completed 2017-02-13
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27401586

DOI: Digital Object Identifier

10.1016/j.ijid.2016.07.003

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