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Changes in body mass index during gonadotropin-releasing hormone agonist treatment for central precocious puberty and early puberty.

Author: HwangJin Soon, LeeHae Sang, RohJung Ki, YoonJong Seo

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated changes in body mass index (BMI) in 383 girls treated with depot leuprolide acetate monthly for at least 2 years. After 2 years of treatment, BMI standard deviation score (SDS) increased significantly only in normal weight children. Although the difference in BMI SDS was relatively small, it increased significantly after 2 years of treatment in normal weight girls with early pubertal development.
Paper Details　
Original Abstract of the Article :
Gonadotropin-releasing hormone agonists (GnRHa) have been widely used for decades to treat patients with central precocious puberty (CPP). Several studies have investigated changes in body composition in patients with CPP following GnRHa treatment, but the results are inconsistent. The aim of this s...See full text at original site
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引用元：
https://doi.org/10.1007/s12020-016-1023-5

データ提供：米国国立医学図書館（NLM）

Investigating BMI Changes During GnRHa Treatment for Puberty

Precocious puberty, the early onset of puberty, can have a significant impact on a child's physical and emotional development. This study examines the changes in body mass index (BMI) in children treated with gonadotropin-releasing hormone agonists (GnRHa) for central precocious puberty (CPP) and early puberty. The authors analyzed data from 383 girls who received depot leuprolide acetate treatment for at least two years, investigating the impact of BMI on treatment outcomes.

Navigating the Landscape of Puberty Treatment

The study reveals that BMI changes during GnRHa treatment vary depending on the child's initial BMI status. While BMI increased significantly in normal-weight children, it remained stable in overweight and obese children. This finding highlights the importance of considering the individual child's BMI status when evaluating treatment outcomes.

A Closer Look at the Effects of GnRHa Treatment

This research provides valuable insights into the potential impact of GnRHa treatment on BMI in children with CPP and early puberty. It underscores the need for careful monitoring of BMI changes during treatment and for tailoring treatment strategies to address individual patient needs. This is a valuable contribution to the ongoing research on managing puberty disorders, offering a deeper understanding of the complex interplay between treatment, BMI, and overall health outcomes.

Dr.Camel's Conclusion

This study investigates the changes in body mass index during GnRHa treatment for central precocious puberty and early puberty. The research highlights the importance of considering the individual child's BMI status when evaluating treatment outcomes and underscores the need for careful monitoring of BMI changes during treatment. This is a valuable contribution to the ongoing research on managing puberty disorders, offering a deeper understanding of the complex interplay between treatment, BMI, and overall health outcomes.

Date :
  1. Date Completed 2017-07-07
  2. Date Revised 2019-02-21
Further Info :

Pubmed ID

27444748

DOI: Digital Object Identifier

10.1007/s12020-016-1023-5

Related Literature

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・Effects of leuprolide injection
SNS
PICO Info
in preparation
Languages

English

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