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Clinical effects of the fetal estrogen estetrol in a multiple-rising-dose study in postmenopausal women.

Author: Coelingh BenninkHerjan J T, FoidartJean-Michel, Gemzell-DanielssonKristina, VerhoevenCarole, VisserMonique, ZimmermanYvette

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Estetrol, a natural fetal estrogen, was found to be safe and effective in improving vaginal cytology and vasomotor symptoms in postmenopausal women at doses ranging from 2 to 40 mg per day. However, endometrial proliferation occurred at the 10 mg dose.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Estetrol (E4) is a natural fetal estrogen. The safety of increasing doses of E4 and its preliminary effects on the vagina, endometrium and menopausal vasomotor symptoms were investigated. STUDY DESIGN: This was a partly randomized, open-label, multiple-rising-dose study in 49 postmenopau...See full text at original site
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引用元：
https://doi.org/10.1016/j.maturitas.2016.06.017

データ提供：米国国立医学図書館（NLM）

Estetrol: A Potential New Frontier in Menopausal Hormone Therapy

Menopause, a natural transition for women, can sometimes bring challenges such as vaginal atrophy and vasomotor symptoms. This research investigates the potential of estetrol, a natural fetal estrogen, as a treatment option for postmenopausal women. The authors explore the safety and efficacy of estetrol in addressing vaginal and endometrial changes, as well as menopausal vasomotor symptoms. Their findings suggest that estetrol may offer a safe and effective alternative to traditional hormone therapy.

Estetrol: A Promising Treatment for Menopausal Symptoms

This research suggests that estetrol, a natural fetal estrogen, appears to be a safe and effective treatment for postmenopausal women. The study's authors found that estetrol improved vaginal cytology and reduced vasomotor symptoms, indicating its potential as a valuable treatment for menopausal challenges. While further research is needed, these findings provide a promising outlook for the development of estetrol as a new option for menopausal hormone therapy.

A Journey Through Menopause: Estetrol's Potential

Imagine a desert oasis, offering respite and nourishment to those traversing the arid landscape. This research explores the potential of estetrol to provide comfort and relief to women navigating the challenges of menopause. Estetrol's ability to improve vaginal health and reduce vasomotor symptoms offers a potential path towards a more balanced and enjoyable journey through this life transition.

Dr.Camel's Conclusion

This research provides evidence that estetrol, a natural fetal estrogen, may offer a safe and effective treatment for postmenopausal women. Estetrol's ability to improve vaginal cytology and reduce vasomotor symptoms suggests its potential as a valuable new option for menopausal hormone therapy.
Date :
  1. Date Completed 2017-04-25
  2. Date Revised 2022-04-08
Further Info :

Pubmed ID

27451327

DOI: Digital Object Identifier

10.1016/j.maturitas.2016.06.017

SNS
PICO Info
in preparation
Languages

English

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