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[New oral anticoagulants (NOAC) in nephrology].

Author: BellasiAntonio, CampanaCarlo, CozzolinoMario, Di IorioBiagio, Di LulloLuca, ManganoStefano, MelfaGianvincenzo, MinorettiClaudio, RattiCarlo, VolpiMaurizio

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Overview

This review provides an overview of the pharmacokinetics, risk factors for bleeding, and interventions to reverse the anticoagulant effect of new oral anticoagulants (NOACs) or direct oral anticoagulants (DOACs) in the Italian market. The review highlights the importance of adjusting dosage based on renal and liver function and the lack of antidotes for most NOACs/DOACs.
Paper Details　
Original Abstract of the Article :
The new or direct oral anticoagulants [new oral anticoagulants (NOAC) or direct oral anticoagulants (DOAC)] were launched in the Italian market in 2013. Although these compounds share common pharmacological indications with vitamin K antagonists (warfarin or acenocumarol), they have different mechan...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/27545637

データ提供：米国国立医学図書館（NLM）

Navigating the New Landscape of Oral Anticoagulants in Nephrology

This review examines the emergence of new oral anticoagulants (NOACs), specifically their use in nephrology, the field dealing with kidney diseases. NOACs offer an alternative to traditional vitamin K antagonists like warfarin, providing a more convenient and often safer option for managing blood clots. The review focuses on the pharmacokinetic properties of NOACs, especially how their effectiveness can be influenced by kidney function, and discusses the challenges of managing bleeding complications and the lack of readily available antidotes for some NOACs.

NOACs: Balancing Benefits and Risks in Nephrology

The review highlights the complex considerations involved in using NOACs in patients with kidney disease. While these drugs offer a potentially more effective and convenient approach to anticoagulation, their pharmacokinetics are significantly influenced by renal function. This emphasizes the need for careful monitoring and dose adjustments to ensure safe and effective treatment. The lack of readily available antidotes for some NOACs also poses a significant challenge, requiring careful planning for emergency situations.

Navigating New Treatments: A Multi-faceted Approach

This review underscores the importance of staying abreast of new developments in medical treatments, particularly when it comes to drugs with potentially complex interactions with existing conditions. The use of NOACs in nephrology requires careful consideration of their pharmacokinetic properties, potential side effects, and the availability of appropriate management strategies. It's like navigating a vast desert landscape, where each path presents its own unique challenges and rewards.

Dr. Camel's Conclusion

This review serves as a valuable guide for navigating the new landscape of oral anticoagulants in nephrology. It's a reminder that even seemingly simple advancements in medicine can be accompanied by complex considerations. By approaching these new treatments with a critical eye, we can maximize their benefits while minimizing potential risks for patients with kidney disease.

Date :
  1. Date Completed 2017-10-19
  2. Date Revised 2017-10-19
Further Info :

Pubmed ID

27545637

DOI: Digital Object Identifier

gin/00244.12

SNS
PICO Info
in preparation
Languages

Italian

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