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Histone deacetylase inhibitors: Future therapeutics for insulin resistance and type 2 diabetes.

Author: SharmaSorabh, TaliyanRajeev

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

Insulin resistance is a common feature of obesity. This review focuses on the regulation of insulin signaling by HDACs and the future scope of HDAC inhibitors as therapeutics for insulin resistance.
Paper Details　
Original Abstract of the Article :
Insulin resistance is a common feature of obesity and predisposes the affected individuals to a variety of pathologies, including type 2 diabetes mellitus (T2DM), dyslipidemias, hypertension, cardiovascular disease etc. Insulin resistance is the primary cause of T2DM and it occurs many years before ...See full text at original site
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引用元：
https://doi.org/10.1016/j.phrs.2016.09.009

データ提供：米国国立医学図書館（NLM）

Histone Deacetylase Inhibitors: A New Oasis in the Desert of Insulin Resistance

Insulin resistance, a common feature of obesity and a precursor to type 2 diabetes, poses a significant health challenge. This study explores the potential of histone deacetylase (HDAC) inhibitors as a novel therapeutic approach for managing insulin resistance and type 2 diabetes. The authors delve into the intricate mechanisms by which HDACs regulate insulin signaling and the potential benefits of HDAC inhibitors in restoring insulin sensitivity.

A New Frontier: HDAC Inhibitors for Insulin Resistance and Type 2 Diabetes

This study, like a camel discovering a hidden oasis in a vast desert, uncovers the potential of HDAC inhibitors as a promising therapeutic approach for insulin resistance. The authors provide a comprehensive overview of the role of HDACs in insulin signaling and the potential benefits of HDAC inhibitors in restoring insulin sensitivity. The research highlights the need for further investigation into the efficacy and safety of HDAC inhibitors as a therapeutic strategy for insulin resistance and type 2 diabetes.

Health Implications and Lifestyle Applications

Insulin resistance is a serious health condition that can lead to type 2 diabetes. This study suggests that HDAC inhibitors could offer a novel therapeutic approach for managing insulin resistance. However, it's important to consult with a healthcare professional to discuss the best treatment options for your individual needs. It's also crucial to adopt healthy lifestyle habits, such as regular exercise and a balanced diet, to support metabolic health and reduce the risk of insulin resistance.

Dr.Camel's Conclusion

The desert of insulin resistance can be a challenging journey, but this study offers a glimmer of hope in the form of HDAC inhibitors. The research highlights the importance of exploring new therapeutic approaches and underscores the need for continued research to develop effective and safe treatments for insulin resistance and type 2 diabetes.

Date :
  1. Date Completed 2017-12-20
  2. Date Revised 2022-03-11
Further Info :

Pubmed ID

27620069

DOI: Digital Object Identifier

10.1016/j.phrs.2016.09.009

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