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Collagen and α-Tubulin of Mouse Tympanic Membrane Fibroblasts Treated with Quinolones and Aminoglycosides.

Author: AntonelliPatrick J, DirainCarolyn O, Milne-DaviesBailey A, OrobelloNicklas C

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This study assessed the impact of quinolone and aminoglycoside antibiotics, at concentrations found in eardrops, on collagen and α-tubulin levels in mouse tympanic membrane fibroblasts. The study found that some antibiotics, including ciprofloxacin, neomycin + polymyxin B + hydrocortisone, and moxifloxacin, were associated with reduced collagen and α-tubulin levels, potentially affecting tympanic membrane function.
Paper Details　
Original Abstract of the Article :
Objective To assess collagen and α-tubulin levels of mouse tympanic membrane fibroblasts treated with quinolone and aminoglycoside antibiotics at concentrations found in eardrops. Study Design Prospective controlled cell culture study. Setting Academic tertiary medical center. Subjects Mouse tympani...See full text at original site
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引用元：
https://doi.org/10.1177/0194599816672627

データ提供：米国国立医学図書館（NLM）

Collagen and α-Tubulin Levels in Tympanic Membrane Fibroblasts Treated with Quinolones and Aminoglycosides

This research ventures into the realm of otology, specifically focusing on the impact of various antibiotics on the structure and function of the tympanic membrane, a delicate structure akin to a desert oasis. The study, conducted on mouse tympanic membrane fibroblasts, investigated the effects of quinolone and aminoglycoside antibiotics, commonly used in eardrops, on collagen and α-tubulin levels.

Understanding the Potential Impact of Antibiotics on Ear Health

The study reveals the potential impact of certain antibiotics on the structural integrity of the tympanic membrane. By examining the effects of various antibiotics on collagen and α-tubulin levels, the researchers provide valuable insights into the potential risks associated with topical antibiotic use in the ear.

Informed Selection of Ototopical Therapy

This research underscores the importance of choosing ototopical antibiotics with caution, considering the potential impact on tympanic membrane structure and function. By understanding the drug-specific effects, healthcare professionals can make informed decisions about antibiotic therapy, ensuring the best possible outcomes for their patients.

Dr. Camel's Conclusion

This study sheds light on the delicate balance between therapeutic efficacy and potential side effects of ototopical antibiotics. By understanding the specific effects of different antibiotics on the tympanic membrane, healthcare professionals can select the most appropriate treatment options, ensuring both effective treatment and preservation of ear health.
Date :
  1. Date Completed 2017-07-24
  2. Date Revised 2018-03-27
Further Info :

Pubmed ID

27677596

DOI: Digital Object Identifier

10.1177/0194599816672627

Related Literature

Article Analysis
・Effects of neomycin polymyxin
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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