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Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.

Author: , BussièresJean S, ByrneKelly, ChanMatthew T V, CooperD James, ForbesAndrew, JayarajahMohandas, LandoniGiovanni, MarascoSilvana, McGuinnessShay, McNeilJohn, MylesPaul S, PainterThomas, SilbertBrendan, SmithJulian A, WallaceSophie

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Overview

This trial with a 2-by-2 factorial design randomly assigned patients scheduled to undergo coronary-artery surgery to receive tranexamic acid or placebo. Among patients undergoing coronary-artery surgery, tranexamic acid was associated with a lower risk of bleeding than was placebo, without a higher risk of death or thrombotic complications within 30 days after surgery.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Tranexamic acid reduces the risk of bleeding among patients undergoing cardiac surgery, but it is unclear whether this leads to improved outcomes. Furthermore, there are concerns that tranexamic acid may have prothrombotic and proconvulsant effects. METHODS: In a trial with a 2-by-2 fac...See full text at original site
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引用元：
https://doi.org/10.1056/NEJMoa1606424

データ提供：米国国立医学図書館（NLM）

Tranexamic Acid: A Balancing Act in Coronary-Artery Surgery

This research delves into the potential benefits and risks of [tranexamic acid] in [coronary-artery surgery], a common procedure with a high risk of [bleeding]. The study, conducted using a [2-by-2 factorial design], investigates the impact of [tranexamic acid] on both [bleeding] and [thrombotic complications] in this patient population.

Tranexamic Acid: Reducing Bleeding, But With Potential Trade-offs

The study found that [tranexamic acid] was associated with a lower risk of [bleeding] compared to [placebo], resulting in a significant reduction in the need for [blood transfusions]. However, the medication was also associated with a higher risk of [postoperative seizures]. This highlights the complex nature of [tranexamic acid], requiring a careful assessment of the potential benefits and risks in each patient's individual situation.

Navigating the Risks and Rewards of Coronary-Artery Surgery: Making Informed Choices

Imagine a camel traversing a vast desert, encountering both treacherous terrain and valuable oases. Similarly, [coronary-artery surgery] presents both risks and potential rewards. This research emphasizes the importance of informed decision-making, weighing the potential benefits of [tranexamic acid] in reducing [bleeding] against the increased risk of [seizures].

Dr. Camel's Conclusion

Tranexamic acid, like a double-edged sword, can both protect and pose a risk. While it can be a valuable tool in reducing [bleeding] during [coronary-artery surgery], its potential for causing [seizures] must be considered carefully. Navigating the landscape of medical treatments requires a careful balance between potential benefits and risks, making informed decisions crucial for optimal patient care.
Date :
  1. Date Completed 2017-01-19
  2. Date Revised 2022-03-21
Further Info :

Pubmed ID

27774838

DOI: Digital Object Identifier

10.1056/NEJMoa1606424

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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