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Impact of local treatment on overall survival of patients with metastatic prostate cancer: systematic review and meta-analysis.

Author: BaccagliniWilly, BernardoWanderley Marques, CarneiroArie, CarvalhoIcaro Thiago de, GlinaFelipe P A, KayanoPaulo P, LemosGustavo Caserta, NunesVictor M, SmaletzOren

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and meta-analysis evaluated the impact of local treatment on overall survival and cancer-specific survival in patients with metastatic prostatic cancer (MPCa). Overall survival in three years was significantly higher in patients submitted to LT versus NLT (64.2% vs. 44.5%; RD 0.19, 95% CI, 0.17-0.21; p<0.00001; I²=0%).
Paper Details　
Original Abstract of the Article :
CONTEXT: Currently, standard treatment of metastatic prostatic cancer (MPCa) is androgen-deprivation therapy (ADT). Recent studies suggested that local treatment of MPCa is related to increase of survival of those patients, as observed in other tumors. OBJECTIVE: To evaluate the impact of local tre...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5557433/

データ提供：米国国立医学図書館（NLM）

Local Treatment: A Game Changer for Metastatic Prostate Cancer

Metastatic prostate cancer (MPCa) presents a significant challenge for treatment. While androgen-deprivation therapy (ADT) is a standard approach, recent research has explored the potential benefits of local treatment, such as radiotherapy, surgery, or brachytherapy. This systematic review and meta-analysis of six studies involving 34,338 patients with MPCa reveals that local treatment significantly improves overall survival and cancer-specific survival, suggesting that it may play a crucial role in managing this complex disease.

Local Treatment: A Promising Avenue for Metastatic Prostate Cancer

This meta-analysis provides compelling evidence supporting the effectiveness of local treatment in patients with metastatic prostate cancer. It's like finding a new, more effective weapon in the fight against this challenging disease. The findings underscore the importance of considering local treatment options as a potential strategy for improving overall survival and quality of life for individuals with MPCa.

Optimizing Treatment Strategies: Local Treatment for Prostate Cancer

Prostate cancer is a complex disease with a variety of treatment options. This research emphasizes the importance of considering local treatment in conjunction with other standard therapies. It's like navigating a challenging desert terrain, utilizing a multi-pronged approach to overcome the obstacles of this disease. The findings suggest that local treatment could be a valuable tool in the fight against prostate cancer.

Dr. Camel's Conclusion

This meta-analysis provides valuable insights into the potential benefits of local treatment for metastatic prostate cancer. It's like finding a new, more efficient way to navigate the challenging terrain of this disease. The findings suggest that local treatment can be a powerful tool for improving survival and quality of life, and further research into its optimal application is warranted.

Date :
  1. Date Completed 2017-11-09
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

27802009

DOI: Digital Object Identifier

PMC5557433

Related Literature

Article Analysis
・Effective treatment of prostate cancer
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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