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Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report.

Author: ChoYou Sook, KangSun Myoung, KimTae Bum, KwonHyouk Soo, LeeHoonhee, LeeJi Hyang, MoonHee Bom, OhKyunghwan, ParkHyungjun, ParkSo Young

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.

Overview

This report describes a case of a 37-year-old male who developed severe hypersensitivity reactions to palonosetron, a 5-HT-3 receptor antagonist used for preventing postoperative nausea and vomiting, during surgery for kidney donation. This highlights the possibility of patients experiencing severe adverse reactions to palonosetron, even though it is generally considered safe.
Paper Details　
Original Abstract of the Article :
Palonosetron is a 5-hydroxytryptamine-3 (5-HT-3) receptor antagonist used for preventing postoperative nausea and vomiting. Compared with ondansetron and granisetron, it is a better drug because of prolonged action and minimal side effects. Some adverse effects of palonosetron have been reported. In...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5102841/

データ提供：米国国立医学図書館（NLM）

Palonosetron-Induced Anaphylaxis During General Anesthesia: A Case Report

This case report describes a patient who experienced [severe hypersensitivity reactions to palonosetron] during [general anesthesia]. Palonosetron is a commonly used drug to prevent postoperative nausea and vomiting. This case report highlights the potential for severe adverse reactions to palonosetron and emphasizes the need for vigilance among healthcare professionals.

A Rare but Serious Adverse Reaction to Palonosetron

The patient presented with [a rapid drop in blood pressure, facial edema, rash, conjunctival swelling, and wheezing] after receiving palonosetron. These symptoms are consistent with [anaphylaxis], a life-threatening allergic reaction. The patient was successfully resuscitated, but this case underscores the importance of recognizing and managing anaphylaxis promptly. The study also found that [the patient had a positive skin test for hypersensitivity to palonosetron], confirming the diagnosis of palonosetron-induced anaphylaxis.

Importance of Patient History and Allergy Assessment

This case report emphasizes the importance of [thorough patient history and allergy assessment] before administering medications, particularly those with the potential for severe allergic reactions. Healthcare professionals should be aware of the potential for anaphylaxis to commonly used medications like palonosetron. It is crucial to have [appropriate emergency procedures and medications] readily available to manage anaphylaxis in case of an allergic reaction.

Dr.Camel's Conclusion

This case report serves as a reminder that even seemingly safe medications can trigger severe allergic reactions. It's like discovering a hidden scorpion in a beautiful oasis, highlighting the importance of caution and preparedness. This case underscores the critical need for vigilance in patient care, particularly when administering medications with the potential for severe allergic reactions.

Date :
  1. Date Completed n.d.
  2. Date Revised 2020-09-30
Further Info :

Pubmed ID

27826967

DOI: Digital Object Identifier

PMC5102841

SNS
PICO Info
in preparation
Languages

English

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