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Biologic or tofacitinib monotherapy for rheumatoid arthritis in people with traditional disease-modifying anti-rheumatic drug (DMARD) failure: a Cochrane Systematic Review and network meta-analysis (NMA).

Author: HossainAlomgir, MudanoAmy S, SinghJasvinder A, Tanjong GhogomuElizabeth, TugwellPeter, WellsGeorge A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review and network meta-analysis updated a previous Cochrane Overview on biologics for rheumatoid arthritis (RA), focusing on biologic monotherapy in patients who had failed treatment with traditional disease-modifying anti-rheumatic drugs (DMARDs), including methotrexate (MTX).
Paper Details　
Original Abstract of the Article :
We performed a systematic review, a standard meta-analysis and network meta-analysis (NMA), which updates the 2009 Cochrane Overview, 'Biologics for rheumatoid arthritis (RA)'. This review is focused on biologic monotherapy in people with RA in whom treatment with traditional disease-modifying anti-...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6469573/

データ提供：米国国立医学図書館（NLM）

Navigating Rheumatoid Arthritis Treatment: Biologics or Tofacitinib?

Rheumatoid arthritis (RA), like a desert sandstorm, can wreak havoc on joints, causing pain, inflammation, and stiffness. This research explores the treatment landscape for RA, comparing the effectiveness of biologic monotherapy and tofacitinib monotherapy in individuals who have not responded well to traditional disease-modifying anti-rheumatic drugs (DMARDs), including methotrexate. The study, a Cochrane Systematic Review and network meta-analysis, sought to provide a comprehensive assessment of these treatment options.

The findings indicate that both biologic monotherapy and tofacitinib monotherapy are effective treatment options for RA in individuals with MTX/other DMARD failure. However, the authors caution that the evidence base for tofacitinib is relatively limited compared to biologics.

Effective Treatment Options for Rheumatoid Arthritis

This systematic review provides valuable information for healthcare providers and individuals with RA who have not responded well to traditional DMARDs. The findings suggest that both biologics and tofacitinib offer promising treatment options, but the evidence base for tofacitinib is still emerging.

The Importance of Personalized Treatment Approaches

The study emphasizes the importance of individualized treatment approaches for RA, taking into account factors such as disease severity, individual patient preferences, and potential side effects.

Dr. Camel's Conclusion

Just as a camel adapts to the changing landscapes of the desert, individuals with RA require personalized treatment strategies to navigate the complexities of their condition. This systematic review provides a roadmap for effective treatment options, highlighting the importance of collaborative decision-making between healthcare providers and patients.

Date :
  1. Date Completed 2016-12-22
  2. Date Revised 2023-07-22
Further Info :

Pubmed ID

27855242

DOI: Digital Object Identifier

PMC6469573

Related Literature

Article Analysis
・Effective treatment of rheumatoid arthritis
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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