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Prognostic biomarkers to identify patients destined to develop severe Crohn's disease who may benefit from early biological therapy: protocol for a systematic review, meta-analysis and external validation.

Author: AhmadTariq, BhatnagarGauraang, BloomStuart, BooneDarren, HalliganSteve, MallettSusan, Rodriguez-JustoManuel, TaylorStuart A

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.

Overview

This systematic review and meta-analysis examines the use of biological therapy for Crohn's disease. The study aims to identify biomarkers that can predict the development of severe disease, enabling earlier intervention with biological therapies.
Paper Details　
Original Abstract of the Article :
It is believed increasingly that patients with severe Crohn's disease are best treated early with biological therapy, which may ameliorate subsequent disease course and diminish long-term complications. However, we cannot predict currently which new presentations of Crohn's disease are destined to d...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5131410/

データ提供：米国国立医学図書館（NLM）

Prognostic Biomarkers to Identify Patients Destined to Develop Severe Crohn's Disease

Crohn's disease, a chronic inflammatory bowel disease, can cause significant discomfort and complications. This research focuses on identifying biomarkers that could predict which patients with Crohn's disease are at risk of developing severe disease, allowing for early and targeted interventions. The goal is to identify these patients so they can benefit from early treatment and reduce the likelihood of long-term complications.

Biomarkers and Crohn's Disease Management

This study aims to identify reliable biomarkers that can predict the severity of Crohn's disease. If successful, these biomarkers could be used to tailor treatment strategies to individual patients, leading to more effective disease management and potentially minimizing the long-term consequences of Crohn's disease.

Importance of Early Intervention in Crohn's Disease

Early intervention in Crohn's disease is crucial for minimizing the long-term impact of the disease. Identifying biomarkers that can predict disease severity could lead to a paradigm shift in Crohn's disease management, allowing for personalized treatment plans that are tailored to each individual's needs.

Dr.Camel's Conclusion

Like a camel navigating the treacherous dunes of the desert, patients with Crohn's disease face challenges in managing their condition. This research strives to find the hidden oases of biomarkers that can guide us in navigating these challenges, leading to more effective treatments and improved outcomes.

Date :
  1. Date Completed 2018-01-30
  2. Date Revised 2022-01-29
Further Info :

Pubmed ID

27903285

DOI: Digital Object Identifier

PMC5131410

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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