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Oral toxicity study of certain plant extracts containing pyrrolizidine alkaloids.

Author: BărbuceanuFlorica, ChiriŢăCornel, GonciarVeaceslav, GuŢuClaudia Maria, IlieMihaela, IonicăFloriana Elvira, MarginăDenisa Marilena, NegreşSimona, OlaruOctavian Tudorel, ŞeremetOana Cristina

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the safety of dry extracts from four traditional phytotherapeutic species containing pyrrolizidine alkaloids (PAs), which are toxic compounds associated with liver damage. The extracts were found to be safe in acute and subacute toxicity testing, with no deaths or signs of toxicity observed. No significant differences in biochemical parameters were observed between the control and treated groups. The histopathological lesions observed were nonspecific and not consistent with PAs exposure. Further long-term studies are needed to confirm the safety of plant extracts containing PAs.
Paper Details　
Original Abstract of the Article :
Pyrrolizidine alkaloids (PAs) are a class of toxic compounds which are found in plants. Poisoning caused by these toxins is associated with acute and chronic liver damage. Tussilago farfara (coltsfoot), Petasites hybridus (common butterbur), Senecio vernalis (eastern groundsel) and Symphytum officin...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/28002518

データ提供：米国国立医学図書館（NLM）

The Toxicity of Pyrrolizidine Alkaloids: Navigating a Desert of Potential Hazards

Pyrrolizidine alkaloids (PAs), a class of toxic compounds found in various plants, pose a significant threat to human health. This research explores the potential toxicity of dry extracts from plants containing PAs, specifically coltsfoot, common butterbur, eastern groundsel, and comfrey. The researchers aimed to assess the safety of these extracts in animal models.

The Toxicity of Pyrrolizidine Alkaloids: Navigating a Desert of Potential Hazards

The study found that the tested dry extracts, even at doses containing PAs above the limits imposed in some countries, did not produce significant hepatic or biliary toxic effects in animals. However, the researchers emphasize the need for further studies over longer time periods to fully assess the safety of these extracts.

Navigating the Desert of Herbal Remedies: Understanding Potential Risks

The study's findings highlight the importance of understanding the potential risks associated with herbal remedies. While many plant extracts offer therapeutic benefits, it is crucial to be aware of the potential for toxicity, particularly when using plants containing PAs. Further research is needed to establish clear safety guidelines for the use of these extracts.

Dr.Camel's Conclusion

This research is a journey through the vast desert of herbal remedies, highlighting the importance of careful consideration when using plant extracts containing potentially toxic compounds. By understanding the potential hazards and seeking further evidence-based guidance, we can navigate this landscape with greater safety and ensure the well-being of those seeking natural remedies.

Date :
  1. Date Completed 2017-05-01
  2. Date Revised 2017-05-01
Further Info :

Pubmed ID

28002518

DOI: Digital Object Identifier

57031610171023

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SNS
PICO Info
in preparation
Languages

English

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