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Glycopyrrolate: pharmacokinetics and some pharmacodynamic findings.

Author: Ali-MelkkiläT, KailaT, KantoJ

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

Glycopyrrolate, a quaternary amine with peripheral antimuscarinic activity, was studied using a radioreceptor assay. The drug was rapidly absorbed after intramuscular injection, but oral administration was not effective.
Paper Details　
Original Abstract of the Article :
In the present study, a sensitive and reproducible radioreceptor assay (RRA) was used to evaluate the basic pharmacokinetic properties of glycopyrrolate, a quaternary amine with peripheral antimuscarinic activity. Based on the plasma levels after a single intravenous injection, 6 micrograms/kg (n = ...See full text at original site
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引用元：
https://doi.org/10.1111/j.1399-6576.1989.tb02956.x

データ提供：米国国立医学図書館（NLM）

The Pharmacokinetics of Glycopyrrolate: A Journey Through the Body

This study delves into the world of pharmacokinetics, exploring the fascinating journey of glycopyrrolate through the body. Glycopyrrolate is a quaternary amine with peripheral antimuscarinic activity. This research aimed to understand the basic pharmacokinetic properties of this medication, essentially mapping out its distribution, metabolism, and elimination in the body.

Measuring the Movement of Glycopyrrolate

The researchers used a sensitive radioreceptor assay (RRA) to meticulously track the movement of glycopyrrolate through the body. This allowed them to determine the distribution phase half-life, the elimination phase half-life, and the distribution volume. The results showed that glycopyrrolate is rapidly absorbed and eliminated from the body, with a relatively short half-life.

The Importance of Effective Delivery

This study also investigated the impact of different routes of administration on the effectiveness of glycopyrrolate. Intramuscular injection resulted in rapid absorption and predictable clinical effects. However, oral administration proved to be less effective. This underscores the importance of choosing the right route of administration to ensure the medication reaches its target effectively.

Dr.Camel's Conclusion

Like a camel navigating a winding path through the desert, glycopyrrolate takes a unique journey through the body. This study illuminates the intricate pharmacokinetic properties of this medication, revealing its rapid absorption and elimination. The study also highlights the importance of choosing the right route of administration to maximize the therapeutic benefits of glycopyrrolate.

Date :
  1. Date Completed 1989-11-03
  2. Date Revised 2019-08-14
Further Info :

Pubmed ID

2800994

DOI: Digital Object Identifier

10.1111/j.1399-6576.1989.tb02956.x

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Languages

English

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