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[Comparison of isosorbide dinitrate and nifedipine in the treatment of variant angina pectoris. Randomized study].

Author: AschermannM, BultasJ, KaretováD, KozákováM, KölbelF, SimperD

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
English AbstractA summary of a research paper/publication written in English for a wider audience.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

This study compared the effectiveness of isosorbide dinitrate and nifedipine in 17 patients with variant angina (chest pain caused by spasms in coronary arteries). Both treatments significantly reduced the number of angina attacks and episodes of ST-segment changes on heart monitoring, both with and without symptoms. Patients also showed improved exercise tolerance. While both medications were effective, three patients experienced severe headaches with isosorbide dinitrate and had to stop the medication. The study concludes that both isosorbide dinitrate and nifedipine are effective treatments for variant angina, but patients should be aware of the potential for headaches with isosorbide dinitrate.
Paper Details　
Original Abstract of the Article :
The effects of isosorbide dinitrate single dose 120 mg daily and nifedipine 20 mg twice daily were studied in 17 patients with variant angina pectoris due to coronary artery spasm. After a placebo phase the patients were randomized to treatment with either isosorbide dinitrate or nifedipine. After s...See full text at original site
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引用元：
https://pubmed.ncbi.nlm.nih.gov/2805034

データ提供：米国国立医学図書館（NLM）

Navigating the Labyrinth of Variant Angina

The human cardiovascular system is a complex and intricate network, much like a labyrinthine desert with hidden pathways. Variant angina, a form of chest pain caused by spasms in the coronary arteries, presents a significant challenge to navigating this intricate system. This study, much like an intrepid explorer venturing into the heart of a desert, explores the effectiveness of two medications, isosorbide dinitrate and nifedipine, in treating variant angina.

Two Paths to Relief: A Comparative Journey

The researchers used a randomized crossover study design, a strategy akin to carefully mapping out different routes through the desert, to compare the effects of these two medications. They found that both isosorbide dinitrate and nifedipine effectively reduced the number of angina attacks and improved exercise tolerance, like discovering two separate oases offering similar refreshment.

A Glimpse of Relief in the Desert of Angina

This research offers valuable insights into the treatment of variant angina, a condition that can severely impact a person's quality of life. The findings suggest that both isosorbide dinitrate and nifedipine may be effective options for managing this condition, providing a potential path towards relief in the desert of angina. It is important to note, however, that isosorbide dinitrate was associated with headache in a small number of patients, highlighting the need for careful consideration of individual patient needs and potential side effects.

Dr.Camel's Conclusion

This research provides a roadmap for navigating the complex terrain of variant angina, a condition that can feel like a relentless desert storm. The study's findings suggest that both isosorbide dinitrate and nifedipine may offer effective treatment options, each with its own unique characteristics. As with any journey through the desert, careful consideration of individual needs and potential pitfalls is crucial.

Date :
  1. Date Completed 1989-12-01
  2. Date Revised 2013-11-21
Further Info :

Pubmed ID

2805034

DOI: Digital Object Identifier

2805034

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Languages

Czech

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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