Paper Details

  1. Home
  2. Paper Details

Early Administration of Glutamine Protects Cardiomyocytes from Post-Cardiac Arrest Acidosis.

Author: BuddhakosaiWaradee, ChenWen-Liang, Hsu ChenCheng, LiChao-Jui, LinYan-Ren, LuHuai-En, SyuShih-Han, WenCheng-Hao, WuHan-Ping

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study investigated the effects of early administration of glutamine on survival and cardiomyocyte protection in a rat model of postcardiac arrest acidosis. Glutamine significantly prolonged survival and decreased cardiomyocyte apoptosis and improved beating function in vitro.
Paper Details　
Original Abstract of the Article :
Postcardiac arrest acidosis can decrease survival. Effective medications without adverse side effects are still not well characterized. We aimed to analyze whether early administration of glutamine could improve survival and protect cardiomyocytes from postcardiac arrest acidosis using animal and ce...See full text at original site
Dr.Camel IconDr.Camel's Paper Summary Blogラクダ博士について

ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
難解な医学論文を、専門知識のない方にも理解しやすいように、噛み砕いて説明することを目指しています。

* ラクダ博士による解説は、あくまで論文の要点をまとめたものであり、原論文の完全な代替となるものではありません。詳細な内容については、必ず原論文をご参照ください。
* ラクダ博士は架空のキャラクターであり、実際の医学研究者や医療従事者とは一切関係がありません。
* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5183754/

データ提供：米国国立医学図書館（NLM）

Glutamine: A Life-Saving Oasis After Cardiac Arrest

Cardiac arrest, like a sudden desert sandstorm, can be a life-threatening event. This study explores the potential benefits of early glutamine administration in protecting cardiomyocytes from post-cardiac arrest acidosis, a dangerous condition that can further compromise heart function. The authors conduct a study using both animal and cell models, akin to observing the effects of different desert environments on different species.

Glutamine: A Protective Shield for the Heart

The study found that early administration of glutamine significantly improved survival in rats with post-cardiac arrest acidosis, suggesting a protective effect on the heart. This is like finding a desert oasis that provides not only water but also a safe refuge from the harsh elements. The authors also observed that glutamine reduced apoptosis and increased beating function in cardiomyocytes exposed to low pH conditions, further supporting its potential as a cardioprotective agent.

A Desert Oasis for the Heart: A Glimmer of Hope

This research offers a promising avenue for developing new therapies to improve survival rates after cardiac arrest. The study suggests that glutamine may act as a protective shield for the heart, mitigating the damage caused by post-cardiac arrest acidosis. This is like discovering a new type of cactus that can withstand the harshest desert conditions, providing a source of sustenance and resilience.

Dr.Camel's Conclusion

This study suggests that early glutamine administration may be a valuable tool for protecting the heart after cardiac arrest. This research is like finding a hidden oasis in the desert of cardiac care, offering a potential solution to a life-threatening condition.

Date :
  1. Date Completed 2017-01-23
  2. Date Revised 2018-11-13
Further Info :

Pubmed ID

28058255

DOI: Digital Object Identifier

PMC5183754

Related Literature

Article Analysis
・Side Effects of l-glutamine
SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

This site uses cookies. Visit our privacy policy page or click the link in any footer for more information and to change your preferences.