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Cholestyramine alters bile acid amounts and the expression of cholesterol-related genes in rabbit intestinal and hepatic tissues.

Author: ChenJian, DingWei Qun, HuangJian Ping, JiangWei Ru, JiangXiao Yun, LuoZhong Guang, QiuDong Ni, ShangQuan, SunDa Yu

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Overview

This study explored how cholestyramine (CHO) regulated serum cholesterol amounts and bile acid levels in animal models. The study found that CHO treatment decreased serum cholesterol levels by 12.1%. Although CHO did not change the bile acid pool size and biliary bile acid output, it significantly increased fecal bile acid output. The study also found that CHO significantly increased the expression and activity of CYP7A1, as well as IBABP and LDL-R mRNA expressions, but decreased hepatic SHP and BSEP gene expressions.
Paper Details　
Original Abstract of the Article :
OBJECTIVE: Cholestyramine (CHO), as a bile acid sequestering exchange resin, has been widely used to treat hypercholesterolemia. The aim of this study was to explore how CHO regulated serum cholesterol amounts and bile acid levels in animal models. METHODS: New Zealand White rabbits were randomly a...See full text at original site
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ラクダ博士は、Health Journal が論文の内容を分かりやすく解説するために作成した架空のキャラクターです。
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* 解説の内容は Health Journal が独自に解釈・作成したものであり、原論文の著者または出版社の見解を反映するものではありません。


引用元：
https://doi.org/10.1111/1751-2980.12445

データ提供：米国国立医学図書館（NLM）

Cholestyramine: A Deep Dive into Its Effects on Bile Acid Metabolism

This study explores the [mechanisms of action] of [cholestyramine], a [bile acid sequestering resin] used to treat [hypercholesterolemia]. The researchers conducted an [animal study] using [rabbits] and found that [cholestyramine] significantly [altered bile acid amounts] and [regulated cholesterol-related gene expression] in [intestinal and hepatic tissues]. They conclude that [cholestyramine] has a [multifaceted effect] on [bile acid metabolism] and [cholesterol homeostasis].

The Desert of Cholesterol: Unveiling the Effects of Cholestyramine

The study offers a detailed look at the complex ways in which cholestyramine, a medication used to lower cholesterol, interacts with the body's natural processes. The research highlights the multifaceted effects of this medication, revealing its influence on bile acid metabolism and cholesterol homeostasis. This knowledge is essential for understanding the mechanisms underlying cholestyramine's therapeutic effects.

Navigating the Labyrinth of Cholesterol Management

Managing cholesterol levels can be like navigating a labyrinth, with many factors influencing its levels and how they affect our health. This study provides valuable insights into the specific mechanisms of cholestyramine, offering a deeper understanding of how this medication helps regulate cholesterol levels and improve overall cardiovascular health.

Dr.Camel's Conclusion

This research provides a detailed analysis of the mechanisms behind cholestyramine's effects on bile acid metabolism and cholesterol homeostasis. The study offers a valuable contribution to our understanding of this important medication and its role in managing cholesterol levels.
Date :
  1. Date Completed 2017-11-20
  2. Date Revised 2017-12-13
Further Info :

Pubmed ID

28067465

DOI: Digital Object Identifier

10.1111/1751-2980.12445

Related Literature

Article Analysis
・Effects of cholestyramine resin
SNS
PICO Info
in preparation
Languages

English

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