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Sedative Effects of Levocetirizine: A Systematic Review and Meta-Analysis of Randomized Controlled Studies.

Author: ChitsuthipakornWirach, KhattiyawittayakunLikhit, SeresirikachornKachorn, SnidvongsKornkiat

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This study investigated the sedative effects of levocetirizine. The study found that levocetirizine has modest sedative effects with a risk ratio of 1.67 when compared with placebo. The sedative effects observed for levocetirizine are not different from other second-generation antihistamines.
Paper Details　
Original Abstract of the Article :
INTRODUCTION: As a substrate of P-glycoprotein, levocetirizine should not cause sedative effects. However, while cetirizine, a mixture of levocetirizine and dextrocetirizine, can slightly penetrate the blood brain barrier, the sedative effects of levocetirizine are still under study. OBJECTIVES: Th...See full text at original site
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引用元：
https://doi.org/10.1007/s40265-016-0682-0

データ提供：米国国立医学図書館（NLM）

Levocetirizine: Sedative Effects Revisited

Antihistamines are commonly used to treat allergies, but some can cause drowsiness. This study investigated the sedative effects of levocetirizine, a second-generation antihistamine, through a systematic review and meta-analysis of randomized controlled trials. The researchers analyzed 48 studies involving 18,014 patients, comparing levocetirizine to other antihistamines and placebo.

Levocetirizine: Modest Sedative Effects

The meta-analysis revealed that levocetirizine had modest sedative effects when compared to placebo. However, when compared to other second-generation antihistamines, levocetirizine did not show significant differences in sedative effects. The study also found that levocetirizine had less sedative effects and less change in reaction time compared to first-generation antihistamines.

Implications for Antihistamine Choice

These findings suggest that levocetirizine is a relatively safe antihistamine with minimal sedative effects. While it may have some sedative effects compared to placebo, it is similar to other second-generation antihistamines in this regard. For patients concerned about drowsiness, levocetirizine may be a suitable option.

Dr. Camel's Conclusion

This study is like a camel caravan carefully navigating through a desert oasis, seeking the perfect balance of relief and alertness. The researchers have provided valuable insights into the sedative effects of levocetirizine, helping us choose the most appropriate antihistamine for our needs.

Date :
  1. Date Completed 2017-04-20
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28070872

DOI: Digital Object Identifier

10.1007/s40265-016-0682-0

SNS
PICO Info
in preparation
Languages

English

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