Long-term effects on the incidence of second primary cancers in a randomized trial of two and five years of adjuvant tamoxifen.

Author: BengtssonNils-Olof, CarstensenJohn, FornanderTommy, HatschekThomas, LindmanHenrik, MalmströmPer-Olof, NordenskjöldBo, RosellJohan, StålOlle, WallgrenArne

Paper Details 
Original Abstract of the Article :
BACKGROUND: Tamoxifen is a well established treatment for breast cancer, but its long-term effects on the incidence of secondary cancers are not fully evaluated. MATERIAL AND METHODS: We have studied 4128 postmenopausal patients with early stage breast cancer who were alive and free of breast cance...See full text at original site
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引用元:
https://doi.org/10.1080/0284186X.2016.1273547

データ提供:米国国立医学図書館(NLM)

Tamoxifen: A Double-Edged Sword in Breast Cancer Treatment

Tamoxifen is a well-established treatment for breast cancer, offering significant benefits in reducing the risk of recurrence. However, its long-term effects on the incidence of secondary cancers remain a subject of ongoing research. This study investigated the impact of different durations of tamoxifen therapy on the occurrence of second primary cancers in a large group of postmenopausal women with early-stage breast cancer. The findings revealed that while five years of tamoxifen treatment was associated with a reduced risk of contralateral breast cancer and lung cancer, it also led to an increased risk of endometrial cancer. This research highlights the complex interplay between the benefits and risks of long-term tamoxifen therapy, necessitating careful consideration of individual patient factors and potential long-term outcomes.

Tamoxifen: Balancing Benefits and Risks

This research sheds light on the complex interplay between the benefits and risks of long-term tamoxifen therapy. It's like a camel traversing a desert, finding a source of nourishment while also encountering potential hazards. While five years of treatment reduced the risk of contralateral breast cancer and lung cancer, it also increased the risk of endometrial cancer. This highlights the importance of carefully weighing the potential benefits and risks of long-term tamoxifen therapy in individual patients. The findings emphasize the need for personalized treatment strategies that consider individual patient factors and potential long-term outcomes.

Navigating the Desert of Breast Cancer Treatment: A Journey Through Informed Decisions

This research offers valuable insights into the complex considerations involved in breast cancer treatment. It's like navigating a vast desert, seeking the best path to manage this challenging condition. The findings emphasize the importance of careful decision-making, considering the potential benefits and risks of long-term tamoxifen therapy. The journey towards optimal treatment outcomes for breast cancer continues, guided by ongoing research and a focus on personalized care.

Dr. Camel's Conclusion

This study underscores the complex considerations involved in long-term tamoxifen therapy for breast cancer. It's like finding a hidden oasis in the desert, offering potential benefits while also revealing potential risks. It highlights the importance of personalized treatment approaches that carefully weigh these factors to ensure optimal patient outcomes.

Date :
  1. Date Completed 2017-04-25
  2. Date Revised 2017-04-25
Further Info :

Pubmed ID

28080180

DOI: Digital Object Identifier

10.1080/0284186X.2016.1273547

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