Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population.

Author: AxelssonTomas, CavalliMarco, ErikssonNiclas, HallbergPär, JohanssonHans-Erik, MagnussonPatrik Ke, NorlingPia, PerssonMatilda, WadeliusClaes, WadeliusMia, YueQun-Ying

Paper Details 
Original Abstract of the Article :
AIM: We conducted a genome-wide association study on angiotensin-converting enzyme inhibitor-induced cough and used our dataset to replicate candidate genes identified in previous studies. PATIENTS & METHODS: A total of 124 patients and 1345 treated controls were genotyped using Illumina arrays. Th...See full text at original site
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引用元:
https://doi.org/10.2217/pgs-2016-0184

データ提供:米国国立医学図書館(NLM)

Exploring Genetic Factors Associated with Angiotensin-Converting Enzyme Inhibitor-Induced Cough

Angiotensin-converting enzyme inhibitors (ACEIs) are widely prescribed medications for managing hypertension, but they can sometimes cause a persistent cough as a side effect. This study investigates potential genetic factors associated with ACEI-induced cough, seeking to identify genes that may contribute to this adverse reaction. The researchers conducted a genome-wide association study (GWAS) on a Swedish population, comparing the genetic profiles of individuals who experienced ACEI-induced cough with those who did not. The study aimed to identify potential genetic markers that could predict susceptibility to ACEI-induced cough. The study identified several genes that were potentially associated with ACEI-induced cough, suggesting that genetic factors may play a role in determining an individual's susceptibility to this side effect.

Genetic Insights into ACEI-Induced Cough

The study's findings provide intriguing insights into the potential genetic basis for ACEI-induced cough, suggesting that genetic predisposition may contribute to this side effect.

Health Implications and Practical Applications

Imagine a desert oasis, where the delicate balance of its ecosystem can be disrupted by a single factor. Similarly, the individual response to medications can be influenced by a complex interplay of genetic and environmental factors. This study highlights the importance of considering genetic factors in personalized medicine, allowing healthcare providers to better tailor treatment strategies to individual patients.

Dr.Camel's Conclusion

This study provides valuable insights into the potential genetic factors contributing to ACEI-induced cough. By identifying these genes, the research opens up new avenues for understanding and potentially predicting this side effect, paving the way for more personalized and effective treatment strategies.

Date :
  1. Date Completed 2017-07-24
  2. Date Revised 2017-07-24
Further Info :

Pubmed ID

28084903

DOI: Digital Object Identifier

10.2217/pgs-2016-0184

SNS
PICO Info
in preparation
Languages

English

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