Side Effects of quinapril: A Synthesis of Findings from 19 Studies

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Original Abstract of the Article

Major Findings

Quinapril is a safe and effective treatment for mild to moderate hypertension, according to several studies. 11 and 8 . Quinapril lowers blood pressure by inhibiting ACE in blood vessels. 3 It has also been shown to be effective in treating heart failure. 2 and 14 and 9 Compared to other ACE inhibitors, quinapril has been suggested to have fewer side effects, especially cough. 14 , 10 and 5 . Although quinapril is a valuable drug for treating hypertension and heart failure, it is important to be aware of its potential side effects, such as cough. 10 and 5 . It is essential to follow your doctor's instructions and monitor for side effects while taking quinapril.

Reasons for side effects

Quinapril lowers blood pressure by inhibiting angiotensin-converting enzyme (ACE). ACE converts angiotensin I to angiotensin II. Angiotensin II constricts blood vessels and promotes aldosterone secretion, which increases blood pressure. By inhibiting ACE, quinapril reduces the production of angiotensin II, thereby lowering blood pressure. However, ACE is also found in tissues such as the lungs and intestines, so inhibiting ACE in these tissues can lead to side effects such as cough.

Common side effects

Cough

Cough is a common side effect of quinapril. 10 and 5 It is thought to be caused by quinapril inhibiting ACE in the lungs. Cough affects approximately 10% of people taking quinapril. 5 Cough often appears a few weeks after starting quinapril. Talk to your doctor if you experience severe coughing.

Taste Disturbances

Taste disturbances may occur with quinapril. 10 This is thought to be caused by quinapril inhibiting ACE in the tongue. Taste disturbances affect about 1% of people taking quinapril.

Headache

Headaches can occur when taking quinapril. About 10% of people taking quinapril experience headaches.

Dizziness

Dizziness can occur with quinapril. About 5% of people taking quinapril experience dizziness.

Low Blood Pressure

Low blood pressure can occur when taking quinapril. This is thought to be caused by quinapril dilating blood vessels. Low blood pressure affects about 1% of people taking quinapril.

Kidney Problems

Kidney problems can occur with quinapril. This is thought to be caused by quinapril inhibiting ACE in the kidneys. Kidney problems affect about 1% of people taking quinapril.

Rash

A rash can occur when taking quinapril. This is thought to be caused by quinapril triggering an allergic reaction. Rash affects about 1% of people taking quinapril.

Measures to address side effects

Cough

If you experience severe coughing, consult your doctor. They may decide to stop your quinapril treatment or switch you to a different medication. Cough often appears a few weeks after starting quinapril, so consult your doctor if you experience coughing in the early stages.

Taste Disturbances

Talk to your doctor if you have taste disturbances. Taste disturbances often appear a few weeks after starting quinapril, so consult your doctor if you experience taste disturbances in the early stages.

Headache

If you experience severe headaches, consult your doctor. They may prescribe a headache medication or consider stopping your quinapril treatment.

Dizziness

Be careful when getting up or walking if you experience dizziness. If you experience severe dizziness, consult your doctor.

Low Blood Pressure

If you are prone to low blood pressure, be careful when getting up or walking. If you are concerned about low blood pressure, consult your doctor.

Kidney Problems

If you have kidney problems, you should avoid taking quinapril. If you are concerned about kidney problems, consult your doctor.

Rash

Consult your doctor immediately if you develop a rash.

Comparison across studies

Commonalities among studies

Multiple studies have shown that quinapril is effective in treating mild to moderate hypertension. 11 and 8 . It has also been shown to be effective in treating heart failure. 2 , 14 and 9 . These studies have confirmed that quinapril reduces blood pressure and improves heart failure symptoms.

Differences among studies

The incidence of side effects from quinapril varies across studies. 10 and 5 . Some studies report cough in approximately 10% of patients taking quinapril. 5 . However, other studies report a lower incidence of cough. 14 This difference could be explained by factors such as the characteristics of the study participants and the dosage of quinapril.

Cautions for real-world application

Quinapril is a valuable drug for treating hypertension and heart failure, but it is important to be aware of its potential side effects. 10 and 5 . It is essential to follow your doctor's instructions and monitor for side effects while taking quinapril. If you experience any side effects, consult your doctor immediately.

Limitations of current research

Research on the side effects of quinapril is still ongoing. More research is needed, particularly on long-term side effects. The incidence of side effects from quinapril may vary depending on factors such as race and age. Therefore, it is important to gather more research data.

Directions for future research

Future research on the side effects of quinapril should investigate long-term side effects and differences in side effect incidence based on factors such as race and age. It is also important to develop new treatments to reduce the side effects of quinapril.

Conclusion

Quinapril is a valuable drug for treating hypertension and heart failure, but it is important to be aware of its potential side effects. 10 and 5 . It is essential to follow your doctor's instructions and monitor for side effects while taking quinapril.

Literature analysis of 19 papers
Positive Content
17
Neutral Content
0
Negative Content
2
Article Type
9
1
1
3
19
1.

[Combined antihypertensive therapy in patients with arterial hypertension and type 2 diabetes].

Author: NesterovIu I, PoltavtsevaO V, BondarevaI N, TepliakovA T

Arterial Hypertension Treatment
Diabetes Treatment
Lipid Metabolism Improvement

Combined therapy with quinapril and indapamide SR effectively reduced blood pressure in patients with arterial hypertension, including those with type 2 diabetes, and improved glucose and lipid metabolism.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : Russian

2.

Effects of quinapril on exercise tolerance in patients with mild to moderate heart failure.

Author: RieggerG A

Exercise tolerance improvement
Heart failure symptom improvement

Quinapril, a non-sulfhydryl angiotensin converting enzyme inhibitor, significantly improved exercise tolerance and symptoms in 225 patients with mild to moderate heart failure. The improvement was dose-related and sustained over 12 months, with no serious side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

4.

CI-906 and CI-907: new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors.

Author: KaplanH R, CohenD M, EssenburgA D, MajorT C, MertzT E, RyanM J

ACE inhibition
Treats hypertension

CI-906 and CI-907, new angiotensin-converting enzyme inhibitors, demonstrated potent, orally active ACE inhibition in guinea pig serum, isolated rabbit aortic rings, and in vivo rat and dog studies. They showed antihypertensive effects in hypertensive rats and dogs with no apparent side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

5.

Angiotensin-converting enzyme inhibitor induced cough compared with placebo, and other antihypertensives: A systematic review, and network meta-analysis.

Author: HuYiyun, LiangLing, LiuShuang, KungJanice Y, BanhHoan Linh

Cardiac mortality and morbidity prevention
Dry cough

Angiotensin converting enzyme inhibitors (ACEIs) are known to cause dry cough. This systematic review and network meta-analysis ranked the risk of cough induced by different ACEIs and compared them to placebo, ARB, or CCB. Moexipril had the highest risk of cough (80.4%), while spirapril had the lowest (12.3%). ACEIs should be avoided in patients at risk of cough, and an ARB or CCB is a possible alternative.

Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.
Meta-AnalysisA statistical technique that integrates the results of multiple studies to draw more general conclusions about a particular issue.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

6.

Genetic variants associated with angiotensin-converting enzyme inhibitor-induced cough: a genome-wide association study in a Swedish population.

Author: HallbergPär, PerssonMatilda, AxelssonTomas, CavalliMarco, NorlingPia, JohanssonHans-Erik, YueQun-Ying, MagnussonPatrik Ke, WadeliusClaes, ErikssonNiclas, WadeliusMia

Angiotensin-converting enzyme inhibitor cough

A genome-wide association study on angiotensin-converting enzyme inhibitor-induced cough identified nearly genome-wide significant associations in several genes, suggesting that the cough may be associated with genes independent of bradykinin pathways.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

7.

Antihypertensive profile of the angiotensin-converting enzyme inhibitors CI-906 and CI-907.

Author: RyanM J, BoucherD M, CohenD M, OlszewskiB J, SingerR M, SmithR D, KaplanH R

ACE inhibition
Treats hypertension

CI-906 and CI-907, new angiotensin-converting enzyme inhibitors, produced dose-dependent decreases in blood pressure in hypertensive rats and dogs, with no adverse side effects.

Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

8.

A postmarketing surveillance evaluation of quinapril in 3742 Canadian hypertensive patients: the ACCEPT Study. Accupril Canadian Clinical Evaluation and Patient Teaching.

Author: LarochelleP, HaynesB, MaronN, DugasS

Hypertension treatment
Cough

This multicenter study evaluated the efficacy and safety of quinapril, an ACE inhibitor, in patients with essential hypertension. After 6 months, 84% of patients were stabilized on quinapril, with greater blood pressure reductions in those who continued treatment. Cough was the most common side effect, reported in 26.2% of patients. Serious adverse events occurred in 1.5% of patients.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

9.

Quinapril in chronic heart failure.

Author: NorthridgeD B, DargieH J

Improved exercise capacity
Improved heart failure

Quinapril, a nonsulfhydryl ACE inhibitor, was found to improve clinical status and exercise capacity in patients with mild to moderate chronic heart failure. In a large, multicenter, randomized, placebo-controlled study of 225 patients, quinapril significantly improved clinical status and exercise capacity in a dose-related manner, with side effects similar to placebo.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.

Language : English

10.

If it is not cough, it must be dysgeusia: differing adverse effects of angiotensin-converting enzyme inhibitors in the same individual.

Author: UnnikrishnanD, MurakondaP, DharmarajanT S

ACE inhibitor adverse reactions
Cough
Dysgeusia

This case report describes a patient who experienced severe dysgeusia (altered taste) after taking enalapril, an angiotensin-converting enzyme (ACE) inhibitor. The authors highlight the importance of considering adverse drug reactions in patients with polypharmacy, especially in nursing home settings.

Case ReportsIn the medical field, a report that describes in detail a unique case, an unusual medical condition, or the effect of a treatment. Provides new insights and possibilities for treatment through individual patient cases.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

11.

Quinapril versus enalapril in the treatment of mild-to-moderate essential hypertension.

Author: SánchezS, LunaA, OrozcoR, VelascoG

Effective hypertension treatment
Safe hypertension treatment
Side effects

Both quinapril and enalapril, angiotensin converting enzyme inhibitors, were found to be safe and effective in treating mild-to-moderate hypertension in 53 patients. Both drugs significantly reduced blood pressure, with no significant between-group differences, and were well tolerated.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

12.

Comparison of quinapril and atenolol as single drugs or in combination with hydrochlorothiazide in moderate to severe hypertensives, using automated ambulatory monitoring.

Author: LacourcièreY, LefebvreJ, ProvencherP, PoirierL

Blood pressure reduction
Hypertension treatment
Increased triglycerides
Raynaud's phenomenon

Quinapril and atenolol are drugs that are used to treat high blood pressure. This study found that both drugs were effective at lowering blood pressure, but that atenolol was more effective at lowering blood pressure during sleep. Atenolol was also associated with an increased risk of side effects, including a severe reaction called Raynaud phenomenon.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

14.

Quinapril in patients with congestive heart failure: controlled trial versus captopril.

Author: AcanforaD, FurgiG, TrojanoL, PiconeC, IannuzziG L, RossiM, PapaA, RengoC, RengoF

Congestive heart failure treatment
Dry cough
Taste-blindness
Unstable angina

Quinapril was as effective as captopril in reducing signs and symptoms of congestive heart failure with fewer side effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Language : English

15.

Benefit and risk evaluation of quinapril hydrochloride.

Author: BarkhordarianMaryam, LawrenceJannel A, UlusanSebahat, ErbayMuhammed Ibrahim, AronowWilbert S, GuptaRahul

Diabetic nephropathy treatment
Heart failure treatment
Hypertension treatment

This review discusses the effectiveness of quinapril hydrochloride, an ACE inhibitor, for hypertension, congestive heart failure, and diabetic nephropathy, highlighting the pivotal role of the ANDI and TREND trials in demonstrating its efficacy.

ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : English

16.

Quinapril, hydrochlorothiazide, and combination in patients with moderate to severe hypertension.

Author: LenzT, SchulteK L, WagnerB, LilienthalJ, GotzenR

Lower blood pressure
Safe for long-term use
None mentioned

This study compared the efficacy and safety of the combination of quinapril and hydrochlorothiazide with each drug as monotherapy in treating hypertension. The combination therapy was more effective than monotherapy in lowering diastolic blood pressure, suggesting its potential benefit in managing hypertension.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

17.

[Angiotensin-converting enzyme inhibitors in the treatment of arterial hypertension].

Author: BabadzhanV D

Hypertension reversibility
Hypotensive effect
Protective effects
Side effects

Angiotensin-converting enzyme (ACE) inhibitors are widely used for hypertension due to their hypotensive effect, low side effects, and organ protection. Different ACE inhibitors have varying clinical efficacy due to their pharmacokinetic properties.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.

Language : Russian

18.

Effect of short-term treatment with bumetanide, quinapril and low-sodium diet on dogs with moderate congestive heart failure.

Author: Martinez-AlcaineM A, YnarajaE, CorberaJ A, MontoyaJ A

Heart failure treatment
Improved control

Bumetanide, quinapril, and a low-sodium diet were safe and effective in treating moderate congestive heart failure in dogs. A prospective study involving 32 dogs with mitral valve disease found that this combination therapy significantly improved clinical signs and was well-tolerated. No major side effects were observed.

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : English

19.

[Combination antihypertensive therapy in patients with an increased risk profile].

Author: BartensW, NauckM, WannerC

Minimized side effects
Reduced dosage

Two fixed antihypertensive drug combinations were effective in lowering blood pressure and had minimal metabolic effects.

Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.
Research Support, Non-U.S. Gov'tResearch funding provided by government agencies outside the United States.

Language : German

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