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Cytochrome 2B6 polymorphism and efavirenz-induced central nervous system symptoms : a substudy of the ANRS ALIZE trial.

Author: , ChêneG, GallienS, JournotV, LoriotM-A, MolinaJ-M, MorlatP, ReliquetV, ReynesJ, SauvageonH

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Genetic variations in the cytochrome P450 (CYP) 2B6 gene have been linked to significant differences in efavirenz pharmacokinetics. However, clinical data on the relationship between CYP2B6 polymorphisms and efavirenz-induced central nervous system (CNS) symptoms is limited.
Paper Details　
Original Abstract of the Article :
Single nucleotide polymorphisms in the cytochrome P450 (CYP) 2B6 gene have been associated with high interindividual variation in efavirenz pharmacokinetics. However, clinical data on the relationship of CYP2B6 polymorphisms with the occurrence of efavirenz-induced central nervous system (CNS) sympt...See full text at original site
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引用元：
https://doi.org/10.1111/hiv.12488

データ提供：米国国立医学図書館（NLM）

CYP2B6 Polymorphism: A Potential Factor in Efavirenz-Induced CNS Symptoms

Efavirenz, a widely used antiretroviral medication, is known to cause central nervous system (CNS) side effects in some individuals. This research explores the potential role of genetic variation in the cytochrome P450 (CYP) 2B6 gene in the occurrence of efavirenz-induced CNS symptoms. The study investigated the relationship between CYP2B6 polymorphisms and the incidence of CNS symptoms in patients receiving efavirenz as part of a larger clinical trial.

The study found that single nucleotide polymorphisms in the CYP2B6 gene were associated with significant interindividual variation in efavirenz pharmacokinetics. However, the researchers found limited clinical evidence to support a direct link between CYP2B6 polymorphisms and the occurrence of efavirenz-induced CNS symptoms. These findings highlight the need for further research to fully understand the complex interplay between genetic factors and efavirenz-induced CNS symptoms.

A Complex Puzzle: Unraveling the Role of Genetics in Medication Response

This research underscores the importance of considering individual genetic variations when prescribing medications, particularly those known to have significant interindividual variability in pharmacokinetics. The study highlights the need for further research to fully understand the complex interplay between genetic factors and medication response. This research serves as a reminder that the journey to personalized medicine is a continuous one, requiring ongoing research and a commitment to tailoring treatment plans to the unique characteristics of each patient.

Dr. Camel's Conclusion

The world of pharmacogenomics is a fascinating and complex one, where genetic variations can profoundly influence the way individuals respond to medications. This research sheds light on the potential role of CYP2B6 polymorphism in efavirenz-induced CNS symptoms. The study's findings underscore the importance of considering individual genetic factors when prescribing medications, especially those known to have significant interindividual variability. As a researcher, I am continually fascinated by the intricate interplay between genetics and pharmacology. This research is a testament to the ongoing quest to personalize medicine and improve patient outcomes by understanding the unique characteristics of each individual.

Date :
  1. Date Completed 2018-04-02
  2. Date Revised 2020-12-09
Further Info :

Pubmed ID

28145050

DOI: Digital Object Identifier

10.1111/hiv.12488

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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