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Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review.

Author: Del RossoJames Q, EadyE Anne, FedorowiczZbys, LaytonAlison M, WhitehouseHeather, van ZuurenEsther J

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
ReviewAn article that critically examines existing research on a particular topic and summarizes the current state of knowledge in the field.
Systematic ReviewA review that systematically collects, evaluates, and integrates relevant research to answer a specific research question.

Overview

This systematic review of randomized controlled trials (RCTs) and case series investigated the evidence for benefits and potential harms of oral spironolactone in the management of acne in adult females. The review found limited evidence to support the expert endorsement of spironolactone at the doses typically used (≤100 mg/day) in everyday clinical practice.
Paper Details　
Original Abstract of the Article :
BACKGROUND: The management of acne in adult females is problematic, with many having a history of treatment failure and some having a predisposition to androgen excess. Alternatives to oral antibiotics and combined oral contraceptives (COCs) are required. OBJECTIVE: Our aim was to conduct a hybrid ...See full text at original site
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引用元：
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5360829/

データ提供：米国国立医学図書館（NLM）

Oral Spironolactone for Acne Vulgaris in Adult Females: A Hybrid Systematic Review

Acne vulgaris, a common skin condition, can feel like a persistent desert sandstorm, leaving individuals feeling self-conscious and frustrated. This hybrid systematic review, published in [Journal Name], examines the evidence for using oral spironolactone to treat acne in adult females.

Spironolactone: A Potential Treatment for Acne in Women

The researchers, like diligent desert researchers, conducted a comprehensive review of available evidence, including randomized controlled trials and case series, to assess the effectiveness and safety of oral spironolactone for treating acne in adult females. While the quality of evidence was limited, the review suggests that spironolactone, like a soothing desert balm, may offer a potential treatment option for acne in adult females, particularly those with a predisposition to androgen excess.

Navigating the Potential Side Effects of Spironolactone

The review also highlights the importance of considering the potential side effects of spironolactone, particularly menstrual irregularities. However, the review emphasizes that routine monitoring of serum potassium levels is not typically required for patients taking spironolactone at the doses commonly used for acne treatment.

Dr. Camel's Conclusion

This hybrid systematic review, like a carefully curated desert guidebook, provides valuable insights into the potential of oral spironolactone for treating acne in adult females. The review underscores the importance of considering individual factors, such as hormone levels and potential side effects, when making treatment decisions. As we continue to explore the vast desert of dermatological research, this review provides a valuable roadmap for understanding and managing this common and often challenging skin condition.
Date :
  1. Date Completed 2017-05-12
  2. Date Revised 2020-03-06
Further Info :

Pubmed ID

28155090

DOI: Digital Object Identifier

PMC5360829

SNS
PICO Info
in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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