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Efficacy and Safety of Donepezil in Chinese Patients with Severe Alzheimer's Disease: A Randomized Controlled Trial.

Author: DoodyRachelle S, JiaJianping, JiaLongfei, LiFangyu, LiangJunhua, ShiLu, TangYi, WeiCuibai, ZhouAihong

Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Multicenter StudyResearch conducted in collaboration with multiple research institutions. It aims to collect a wide range of data and obtain more generalizable results.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

Donepezil was more effective than placebo in treating Chinese patients with severe Alzheimer's disease (AD) over 24 weeks. While the drug was well tolerated, 29 patients experienced serious adverse events (SAEs), with most not considered drug-related.
Paper Details　
Original Abstract of the Article :
BACKGROUND: Donepezil has been used worldwide for the treatment of severe Alzheimer's disease (AD). Whether it is also appropriate for severe AD in Chinese patients remains unknown. OBJECTIVE: To determine whether donepezil is effective and tolerable for Chinese patients with severe AD. METHODS: T...See full text at original site
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引用元：
https://doi.org/10.3233/JAD-161117

データ提供：米国国立医学図書館（NLM）

Navigating the Desert of Alzheimer's Disease: A New Study Explores the Efficacy of Donepezil in Chinese Patients

Alzheimer's disease (AD) is a devastating neurological disorder that affects millions of people worldwide. It's like a relentless desert wind, gradually eroding cognitive function and memory. This study investigates the efficacy and safety of donepezil, a medication commonly used to treat AD, in Chinese patients with severe AD.

The authors conducted a 24-week, double-blind, randomized, placebo-controlled trial involving 313 Chinese patients with severe AD. The study found that donepezil was more effective than placebo in improving cognitive function, as measured by the SIB and CIBIC-plus scores. Furthermore, donepezil was generally well tolerated, with most side effects being mild and not considered drug-related.

A New Oasis in the Desert of Alzheimer's Disease: Hope for Chinese Patients

This study provides valuable evidence that donepezil can be an effective and safe treatment option for Chinese patients with severe AD. It offers a glimmer of hope for those struggling with this debilitating disease.

Finding a Path Through the Desert of Alzheimer's: Understanding Treatment Options and Optimizing Care

This study emphasizes the importance of understanding the unique needs of different populations when treating AD. It highlights the potential benefits of donepezil for Chinese patients, providing crucial information for healthcare providers in tailoring treatment plans to individual patients.

Dr. Camel's Conclusion

This research expands our understanding of the efficacy and safety of donepezil for Chinese patients with severe AD. It offers a valuable addition to the growing body of knowledge about treating this complex and challenging disease. As a researcher, I am encouraged by the potential of donepezil to improve the lives of individuals affected by AD, especially in diverse populations like those in China.

Date :
  1. Date Completed 2018-02-23
  2. Date Revised 2018-12-02
Further Info :

Pubmed ID

28157100

DOI: Digital Object Identifier

10.3233/JAD-161117

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Article Analysis
・Effective treatment of alzheimer's disease
SNS
PICO Info
in preparation
Languages

English

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