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Two-year comparative trial on the immunogenicity and adverse effects of purified chick embryo cell rabies vaccine for pre-exposure immunization.

Author: BrownJ, DreesenD W, FishbeinD B, KempD T

Controlled Clinical TrialA clinical trial that evaluates the effectiveness of a treatment by comparing a group that receives the intervention with a group that receives a placebo or standard treatment.
Clinical TrialA clinical trial is a planned study conducted on humans to evaluate the efficacy and safety of pharmaceuticals, medical devices, and treatment methods. It aims to explore the possibilities of new treatments and improve the health of patients.
Comparative StudyResearch that compares multiple groups/interventions to determine differences/similarities in outcomes/characteristics.
Journal ArticleAn article published in an academic or professional journal that reports original research or scholarly analysis.
Randomized Controlled TrialA clinical trial that randomly assigns participants to treatment and control groups to evaluate the effects of an intervention.

Overview

A purified chick embryo cell (PCEC) rabies vaccine was comparable to the human diploid cell rabies vaccine (HDCV) in immunogenicity and reactogenicity but was less expensive.
Paper Details　
Original Abstract of the Article :
The human diploid cell rabies vaccine (HDCV) has been shown to be highly immunogenic when used for pre-exposure immunization. However, the high cost of the product and the adverse reactions seen following booster doses of HDCV have limited its use. A purified chick embryo cell (PCEC) rabies vaccine ...See full text at original site
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引用元：
https://doi.org/10.1016/0264-410x(89)90152-7

データ提供：米国国立医学図書館（NLM）

A Tale of Two Rabies Vaccines: PCEC vs. HDCV

The field of [vaccination] is constantly seeking safer and more effective ways to protect against infectious diseases. This study compares the immunogenicity and reactogenicity of two rabies vaccines, purified chick embryo cell (PCEC) and human diploid cell (HDCV), in a two-year trial. The authors evaluated the vaccines' effectiveness in inducing protective antibody levels, the duration of antibody persistence, and the anamestic response to booster doses. Their findings demonstrate that PCEC is as effective as HDCV in inducing protective immunity, with a favorable cost-benefit profile.

PCEC: A Cost-Effective Solution for Rabies Prevention

This research suggests that PCEC is a viable and cost-effective alternative to HDCV for rabies pre-exposure immunization. The authors found no significant differences in immunogenicity or reactogenicity between the two vaccines, while PCEC was significantly less expensive to produce. This finding highlights the importance of considering cost-effectiveness alongside safety and efficacy in vaccine development.

Protecting Ourselves from Rabies: A Worldwide Effort

This research underscores the importance of accessible and cost-effective rabies vaccines for global health. The development of PCEC as a safe and effective alternative to HDCV offers a promising solution for combating this potentially fatal disease in resource-limited settings. Rabies prevention is a collective responsibility, and we must continue to invest in research and development to ensure equitable access to effective vaccines.

Dr. Camel's Conclusion

This study is a reminder that even in the seemingly straightforward process of vaccination, there's a vast desert of research and development waiting to be explored. The discovery of PCEC as a cost-effective alternative to HDCV highlights the power of innovation and the potential for more equitable access to life-saving vaccines. It's like finding a hidden spring in the desert of infectious disease prevention, providing hope for a healthier future for all.

Date :
  1. Date Completed 1989-12-08
  2. Date Revised 2019-07-28
Further Info :

Pubmed ID

2815976

DOI: Digital Object Identifier

10.1016/0264-410x(89)90152-7

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in preparation
Languages

English

Positive IndicatorAn AI analysis index that serves as a benchmark for how positive the results of the study are. Note that it is a benchmark and requires careful interpretation and consideration of different perspectives.

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